LAB of Genome Biology > RESEARCH > Disease Resistance
Identification of disease resistance genes in mammals
Predicting resistance or susceptibility to infectious diseases on the basis of the genotypes of animals regarding disease or immune related genes could be important in animal production. We are evaluating the potential influence of the genetic polymorphisms of six immune related genes, porcine beta defensin 4 (pBD4), interferon-induced GTP-binding protein Mx1, natural resistance-associated macrophage protein 1 (Nramp1), toll-like receptor 2 (TLR2), alpha (1,2)-fucosyltransferase (FUT1), and tumor necrosis factor alpha (TNFα) on post-weaning piglet survivability in farms. We selected SNPs that satisfied the criteria of nonsynonymous substitutions and the minor allele frequency >0.1 from each gene, and performed PCR–RFLP. For the Nramp1, TLR2, FUT1, and TNFα SNPs, allele and genotype frequencies were significantly different between the two groups consisting of post-weaning survival and non-survival groups (P<0.05). Our results could suggest that the genetic polymorphisms of Nramp1, TLR2, FUT1, and TNFα affect post-weaning piglet survivability. As DNA marker, the availability of SNPs enriched with immune related genes may be important for studies investigating genetic factors related to disease resistance and susceptibility.
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