LAB of Genome Biology > DB > Innate Immune Gene DB

Innate Immune Gene DB


Gene Symbol Data Source Human Gene ID Pig Gene ID Human Gene Description Pig Gene Description Reference Pubmed ID Reference Title
P1 InnateDB 7494 100217386 X-box binding protein 1 X-box binding protein 1 20351694 Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses
ORAI1 InnateDB 84876 100154923 ORAI calcium release-activated calcium modulator 1 ORAI calcium release-activated calcium modulator 1 21239714 Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection
NLRP7 InnateDB 199713 100516741 NLR family pyrin domain containing 7 NLR family pyrin domain containing 7 15817483 NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens
MUC1 InnateDB 4582 397382 mucin 1, cell surface associated mucin 1, cell surface associated 21868711 Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells
IL25 InnateDB 64806 100154041 interleukin 25 interleukin 25 24631157 Characterization of an interferon-stimulated response element (ISRE) in the Il23a promoter
IL12A InnateDB 3592 397053 interleukin 12A interleukin 12A 22888135 IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection
ZFPM2 InnateDB 23414 100337657 zinc finger protein, FOG family member 2 zinc finger protein, FOG family member 2 21971825 Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter
ZFPM1 InnateDB 161882 110260886 zinc finger protein, FOG family member 1 zinc finger protein, FOG family member 1 21971825 Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter
ZMYND11 InnateDB 10771 100523014 zinc finger MYND-type containing 11 zinc finger MYND-type containing 11 19795416 Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter
ZC3HAV1 InnateDB 56829 100415778 zinc finger CCCH-type containing, antiviral 1 zinc finger CCCH-type containing, antiviral 1 21102435 The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1
ZC3H12A InnateDB 80149 110261148 zinc finger CCCH-type containing 12A zinc finger CCCH-type containing 12A 22037600 Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IκBα gene transcription
ZBTB20 InnateDB 26137 100624908 zinc finger and BTB domain containing 20 zinc finger and BTB domain containing 20 23776228 miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1 infection of CD4(+) T lymphocytes
ZBTB16 InnateDB 7704 100625290 zinc finger and BTB domain containing 16 zinc finger and BTB domain containing 16 25705792 DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA
ZFP36 InnateDB 7538 100316849 ZFP36 ring finger protein ZFP36 ring finger protein 26019272 ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
ZBP1 InnateDB 81030 100144524 Z-DNA binding protein 1 Z-DNA binding protein 1 22423968 Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1
YY1 InnateDB 7528 102162035 YY1 transcription factor YY1 transcription factor 22065573 14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity
YJEFN3 InnateDB 374887 100514276 YjeF N-terminal domain containing 3 YjeF N-terminal domain containing 3 15753091 Differential control of interleukin-6 mRNA levels by cellular distribution of YB-1
YBX1 InnateDB 4904 100620708 Y-box binding protein 1 Y-box binding protein 1 25398005 A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus
XRCC6 InnateDB 2547 100154200 X-ray repair cross complementing 6 X-ray repair cross complementing 6 24098118 Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity
XRCC5 InnateDB 7520 100514133 X-ray repair cross complementing 5 X-ray repair cross complementing 5 24098118 Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity
XIAP InnateDB 331 100037300 X-linked inhibitor of apoptosis X-linked inhibitor of apoptosis 21447281 Sensing cytoplasmic danger signals by the inflammasome
XDH InnateDB 7498 100515259 xanthine dehydrogenase xanthine dehydrogenase 20632067 TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
WNT9B InnateDB 7484 100738655 Wnt family member 9B Wnt family member 9B 23785285 A Wnt/β-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes
WNT3A InnateDB 89780 100514950 Wnt family member 3A Wnt family member 3A 22328140 Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses
WNT2B InnateDB 7482 100520560 Wnt family member 2B Wnt family member 2B 23785285 A Wnt/β-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes
WDR62 InnateDB 284403 100144885 WD repeat domain 62 WD repeat domain 62 19910486 WDFY1 mediates TLR3/4 signaling by recruiting TRIF
WDFY1 InnateDB 57590 100157180 WD repeat and FYVE domain containing 1 WD repeat and FYVE domain containing 1 25736436 Critical roles of the WASP N-terminal domain and Btk in LPS-induced inflammatory response in macrophages
WAS InnateDB 7454 445527 WASP actin nucleation promoting factor WASP actin nucleation promoting factor 22253930 A congenital neutrophil defect syndrome associated with mutations in VPS45
VDR InnateDB 7421 396628 vitamin D receptor vitamin D receptor 19931640 Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation
VLDLR InnateDB 7436 733630 very low density lipoprotein receptor very low density lipoprotein receptor 21642441 The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
VENTX InnateDB 27287 100154934 VENT homeobox VENT homeobox 21670496 Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR4-NF-κB signaling and protects against endotoxin shock
AVP InnateDB 551 396995 arginine vasopressin vasopressin 21615666 A role for collecting duct epithelial cells in renal antibacterial defences
VASP InnateDB 7408 110261011 vasodilator stimulated phosphoprotein vasodilator stimulated phosphoprotein 14679200 MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection
VEGFC InnateDB 7424 100525960 vascular endothelial growth factor C vascular endothelial growth factor C 24656836 RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism
VEGFA InnateDB 7422 397157 vascular endothelial growth factor A vascular endothelial growth factor A 21278304 Vitamin D receptor deletion leads to reduced level of IkappaBalpha protein through protein translation, protein-protein interaction, and post-translational modification
VPS45 InnateDB 11311 100514766 vacuolar protein sorting 45 homolog vacuolar protein sorting 45 homolog 23738510 Retinoic acid-inducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through down-regulation of the very low density lipoprotein receptor
UVRAG InnateDB 7405 100620224 UV radiation resistance associated UV radiation resistance associated 25917095 HSV ICP0 recruits USP7 to modulate TLR-mediated innate response
UCP2 InnateDB 7351 397549 uncoupling protein 2 uncoupling protein 2 23988448 Influenza A virus infection of human respiratory cells induces primary microRNA expression
UNC93B1 InnateDB 81622 100522238 unc-93 homolog B1, TLR signaling regulator unc-93 homolog B1, TLR signaling regulator 21097503 The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade
ULK1 InnateDB 8408 100151990 unc-51 like autophagy activating kinase 1 unc-51 like autophagy activating kinase 1 25792739 MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2
UNC5CL InnateDB 222643 100737363 unc-5 family C-terminal like unc-5 family C-terminal like 22158417 UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
USP7 InnateDB 7874 100190899 ubiquitin specific peptidase 7 ubiquitin specific peptidase 7 18952891 Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation
USP4 InnateDB 7375 100512072 ubiquitin specific peptidase 4 ubiquitin specific peptidase 4 22262844 Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6
USP25 InnateDB 29761 100628105 ubiquitin specific peptidase 25 ubiquitin specific peptidase 25 26305951 Ubiquitin-specific protease 2b negatively regulates IFN-β production and antiviral activity by targeting TANK-binding kinase 1
USP2 InnateDB 9099 100520041 ubiquitin specific peptidase 2 ubiquitin specific peptidase 2 25070846 UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii
UBD InnateDB 10537 100294688 ubiquitin D ubiquitin D 19959714 DNAX-activating protein of 12 kDa impairs host defense in pneumococcal pneumonia
UCHL1 InnateDB 7345 396637 ubiquitin C-terminal hydrolase L1 ubiquitin C-terminal hydrolase L1 23717208 The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling
UBE2W InnateDB 55284 100152196 ubiquitin conjugating enzyme E2 W ubiquitin conjugating enzyme E2 W 26101372 TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription
UBE2V2 InnateDB 7336 100627960 ubiquitin conjugating enzyme E2 V2 ubiquitin conjugating enzyme E2 V2 26101372 TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription
UBE2N InnateDB 7334 100519842 ubiquitin conjugating enzyme E2 N ubiquitin conjugating enzyme E2 N 16862162 IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation
UBE2I InnateDB 7329 100533196 ubiquitin conjugating enzyme E2 I ubiquitin conjugating enzyme E2 I 26348439 IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation
UBQLN1 InnateDB 29979 100622592 ubiquilin 1 ubiquilin 1 21695056 TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription
TPST1 InnateDB 8460 100517581 tyrosylprotein sulfotransferase 1 tyrosylprotein sulfotransferase 1 21665277 Phospholipase Cγ-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation
TNK1 InnateDB 8711 100621720 tyrosine kinase non receptor 1 tyrosine kinase non receptor 1 24449862 LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation
TYK2 InnateDB 7297 397363 tyrosine kinase 2 tyrosine kinase 2 21787891 IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress
YWHAE InnateDB 7531 100620600 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 20462248 GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells
TYRO3 InnateDB 7301 100515870 TYRO3 protein tyrosine kinase TYRO3 protein tyrosine kinase 23954153 A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C)
TP73 InnateDB 7161 102165390 tumor protein p73 tumor protein p73 22976836 Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha)
TP63 InnateDB 8626 100625258 tumor protein p63 tumor protein p63 21367858 p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus
TP53 InnateDB 7157 397276 tumor protein p53 tumor protein p53 21483755 Alteration of lysosome fusion and low-grade inflammation mediated by super-low-dose endotoxin
TNF InnateDB 7124 397086 tumor necrosis factor tumor necrosis factor 21602809 TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages
TUFM InnateDB 7284 100516488 Tu translation elongation factor, mitochondrial Tu translation elongation factor, mitochondrial 22749352 Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity
TSC22D3 InnateDB 1831 100517321 TSC22 domain family member 3 TSC22 domain family member 3 22539300 The role of tuberous sclerosis complex 1 in regulating innate immunity
TSC1 InnateDB 7248 100154726 TSC complex subunit 1 TSC complex subunit 1 22412198 TRPV2 has a pivotal role in macrophage particle binding and phagocytosis
TPH1 InnateDB 7166 100511002 tryptophan hydroxylase 1 tryptophan hydroxylase 1 23243271 TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses
TPP2 InnateDB 7174 100511152 tripeptidyl peptidase 2 tripeptidyl peptidase 2 25525876 Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
TRIM9 InnateDB 114088 100153738 tripartite motif containing 9 tripartite motif containing 9 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM8 InnateDB 81603 100154191 tripartite motif containing 8 tripartite motif containing 8 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM71 InnateDB 131405 100623572 tripartite motif containing 71 tripartite motif containing 71 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM7 InnateDB 81786 100626745 tripartite motif containing 7 tripartite motif containing 7 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM67 InnateDB 440730 100153049 tripartite motif containing 67 tripartite motif containing 67 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM66 InnateDB 9866 100518026 tripartite motif containing 66 tripartite motif containing 66 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM65 InnateDB 201292 100523461 tripartite motif containing 65 tripartite motif containing 65 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM63 InnateDB 84676 100431101 tripartite motif containing 63 tripartite motif containing 63 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM62 InnateDB 55223 100519905 tripartite motif containing 62 tripartite motif containing 62 23077300 The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors
TRIM58 InnateDB 25893 100519825 tripartite motif containing 58 tripartite motif containing 58 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM56 InnateDB 81844 110259886 tripartite motif containing 56 tripartite motif containing 56 21289118 The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors
TRIM55 InnateDB 84675 100152010 tripartite motif containing 55 tripartite motif containing 55 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM50 InnateDB 135892 397383 tripartite motif containing 50 tripartite motif containing 50 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM47 InnateDB 91107 100520974 tripartite motif containing 47 tripartite motif containing 47 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM45 InnateDB 80263 100157373 tripartite motif containing 45 tripartite motif containing 45 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM42 InnateDB 287015 100154919 tripartite motif containing 42 tripartite motif containing 42 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM38 InnateDB 10475 100154512 tripartite motif containing 38 tripartite motif containing 38 23056470 The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors
TRIM37 InnateDB 4591 106505457 tripartite motif containing 37 tripartite motif containing 37 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM36 InnateDB 55521 100519890 tripartite motif containing 36 tripartite motif containing 36 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM32 InnateDB 22954 100737405 tripartite motif containing 32 tripartite motif containing 32 22745133 KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages
TRIM28 InnateDB 10155 110261332 tripartite motif containing 28 tripartite motif containing 28 22995936 The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors
TRIM27 InnateDB 5987 100523617 tripartite motif containing 27 tripartite motif containing 27 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM26 InnateDB 7726 100144460 tripartite motif containing 26 tripartite motif containing 26 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM25 InnateDB 7706 100622285 tripartite motif containing 25 tripartite motif containing 25 17392790 The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors
TRIM24 InnateDB 8805 100620590 tripartite motif containing 24 tripartite motif containing 24 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM23 InnateDB 373 100513958 tripartite motif containing 23 tripartite motif containing 23 20724660 Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity
TRIM21 InnateDB 6737 100302538 tripartite motif containing 21 tripartite motif containing 21 22479513 TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity
TRIM15 InnateDB 89870 100144461 tripartite motif containing 15 tripartite motif containing 15 23077300 The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors
TRIM14 InnateDB 9830 100151834 tripartite motif containing 14 tripartite motif containing 14 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TRIM13 InnateDB 10206 106505285 tripartite motif containing 13 tripartite motif containing 13 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TREML2 InnateDB 79865 100738047 triggering receptor expressed on myeloid cells like 2 triggering receptor expressed on myeloid cells like 2 21804015 TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells
TREM2 InnateDB 54209 100737974 triggering receptor expressed on myeloid cells 2 triggering receptor expressed on myeloid cells 2 21956652 TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating Toll-like receptor signaling and Th1/Th2-type immune responses
TREM1 InnateDB 54210 396601 triggering receptor expressed on myeloid cells 1 triggering receptor expressed on myeloid cells 1 21555403 The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
TRIB3 InnateDB 57761 100518810 tribbles pseudokinase 3 tribbles pseudokinase 3 21220698 Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling
TRIB2 InnateDB 28951 100525217 tribbles pseudokinase 2 tribbles pseudokinase 2 22271508 TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling
TMEM126A InnateDB 84233 100627094 transmembrane protein 126A transmembrane protein 126A 25549946 The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
TMED7 InnateDB 51014 100522183 transmembrane p24 trafficking protein 7 transmembrane p24 trafficking protein 7 22426228 Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
TYROBP InnateDB 7305 397405 transmembrane immune signaling adaptor TYROBP transmembrane immune signaling adaptor TYROBP 25402298 Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors
TRPV2 InnateDB 51393 100523638 transient receptor potential cation channel subfamily V member 2 transient receptor potential cation channel subfamily V member 2 20118928 Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
TRPM5 InnateDB 29850 100533558 transient receptor potential cation channel subfamily M member 5 transient receptor potential cation channel subfamily M member 5 26847546 Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes
TRPM2 InnateDB 7226 100622032 transient receptor potential cation channel subfamily M member 2 transient receptor potential cation channel subfamily M member 2 21709234 The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors
TGFB1 InnateDB 7040 397078 transforming growth factor beta 1 transforming growth factor beta 1 26588780 Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
TCF4 InnateDB 6925 100511671 transcription factor 4 transcription factor 4 18854153 T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
TRAFD1 InnateDB 10906 100154198 TRAF-type zinc finger domain containing 1 TRAF-type zinc finger domain containing 1 18849341 Mutational analysis of TRAF6 reveals a conserved functional role of the RING dimerization interface and a potentially necessary but insufficient role of RING-dependent TRAF6 polyubiquitination towards NF-κB activation
TIFA InnateDB 92610 100513485 TRAF interacting protein with forkhead associated domain TRAF interacting protein with forkhead associated domain 26068852 Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM
TRAIP InnateDB 10293 100626110 TRAF interacting protein TRAF interacting protein 19151749 FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway
TANK InnateDB 10010 100156366 TRAF family member associated NFKB activator TRAF family member associated NFKB activator 21949249 Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12
TICAM2 InnateDB 353376 100520421 TIR domain containing adaptor molecule 2 toll like receptor adaptor molecule 2 21494017 Natural killer cell activation secondary to innate pattern sensing
TICAM1 InnateDB 148022 100623776 TIR domain containing adaptor molecule 1 toll like receptor adaptor molecule 1 21454965 The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection
TLR9 InnateDB 54106 397007 toll like receptor 9 toll like receptor 9 11286707 Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells
TLR8 InnateDB 51311 397384 toll like receptor 8 toll like receptor 8 21734241 The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
TLR7 InnateDB 51284 100037296 toll like receptor 7 toll like receptor 7 17452530 Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice
TLR6 InnateDB 10333 396621 toll like receptor 6 toll like receptor 6 21482737 The structure of the TLR5-flagellin complex: a new mode of pathogen detection, conserved receptor dimerization for signaling
TLR5 InnateDB 7100 100144476 toll like receptor 5 toll like receptor 5 22434932 Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages
TLR4 InnateDB 7099 399541 toll like receptor 4 toll like receptor 4 19923461 Unexpected protective role for Toll-like receptor 3 in the arterial wall
TLR3 InnateDB 7098 100037937 toll like receptor 3 toll like receptor 3 21220319 TLR2 expression in astrocytes is induced by TNF-alpha- and NF-kappa B-dependent pathways
TLR2 InnateDB 7097 396623 toll like receptor 2 toll like receptor 2 18768838 Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88
TLR10 InnateDB 81793 594850 toll like receptor 10 toll like receptor 10 15728506 Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1
TLR1 InnateDB 7096 396607 toll like receptor 1 toll like receptor 1 21439957 TIRAP Ser180Leu polymorphism is associated with Behcet's disease
TOLLIP InnateDB 54472 100625123 toll interacting protein toll interacting protein 25586187 Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1
TRADD InnateDB 8717 100620340 TNFRSF1A associated via death domain TNFRSF1A associated via death domain 18439848 Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands
TNIP3 InnateDB 79931 100738704 TNFAIP3 interacting protein 3 TNFAIP3 interacting protein 3 17088249 Polyubiquitin binding to ABIN1 is required to prevent autoimmunity
TNIP1 InnateDB 10318 100271903 TNFAIP3 interacting protein 1 TNFAIP3 interacting protein 1 21606507 CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
TNFSF9 InnateDB 8744 100736831 TNF superfamily member 9 TNF superfamily member 9 21747409 CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice
TNFSF4 InnateDB 7292 574053 TNF superfamily member 4 TNF superfamily member 4 26564814 TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB
TNFSF11 InnateDB 8600 100037976 TNF superfamily member 11 TNF superfamily member 11 21566133 Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses
TNFSF10 InnateDB 8743 406191 TNF superfamily member 10 TNF superfamily member 10 23498957 CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
TNFRSF9 InnateDB 3604 100519368 TNF receptor superfamily member 9 TNF receptor superfamily member 9 21747409 CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice
TNFRSF1B InnateDB 7133 100037306 TNF receptor superfamily member 1B TNF receptor superfamily member 1B 17220297 TNFRp55 modulates IL-6 and nitric oxide responses following Yersinia lipopolysaccharide stimulation in peritoneal macrophages
TNFRSF1A InnateDB 7132 397020 TNF receptor superfamily member 1A TNF receptor superfamily member 1A 21802165 GITR: a modulator of immune response and inflammation
TNFRSF18 InnateDB 8784 100622025 TNF receptor superfamily member 18 TNF receptor superfamily member 18 19760073 Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection
TNFRSF13C InnateDB 115650 110260624 TNF receptor superfamily member 13C TNF receptor superfamily member 13C 25673724 The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
TNFRSF13B InnateDB 23495 106508259 TNF receptor superfamily member 13B TNF receptor superfamily member 13B 20676093 The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
TNFRSF12A InnateDB 51330 100217390 TNF receptor superfamily member 12A TNF receptor superfamily member 12A 12529173 TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway
TRAF6 InnateDB 7189 396629 TNF receptor associated factor 6 TNF receptor associated factor 6 21185369 MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
TRAF5 InnateDB 7188 396616 TNF receptor associated factor 5 TNF receptor associated factor 5 23951545 Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
TRAF3 InnateDB 7187 100156979 TNF receptor associated factor 3 TNF receptor associated factor 3 16306937 Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice
TRAF2 InnateDB 7186 100513840 TNF receptor associated factor 2 TNF receptor associated factor 2 22546736 TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway
TRAF1 InnateDB 7185 100627029 TNF receptor associated factor 1 TNF receptor associated factor 1 19698991 TRADD protein is an essential component of the RIG-like helicase antiviral pathway
TNFAIP8L2 InnateDB 79626 100155916 TNF alpha induced protein 8 like 2 TNF alpha induced protein 8 like 2 22904303 Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression
TNFAIP3 InnateDB 7128 100622156 TNF alpha induced protein 3 TNF alpha induced protein 3 21220427 Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages
TIRAP InnateDB 114609 100514174 TIR domain containing adaptor protein TIR domain containing adaptor protein 21705416 INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
THRB InnateDB 7068 396776 thyroid hormone receptor beta thyroid hormone receptor beta 20018842 Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity
TSLP InnateDB 85480 100515191 thymic stromal lymphopoietin thymic stromal lymphopoietin 26371187 Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation
THBS1 InnateDB 7057 492313 thrombospondin 1 thrombospondin 1 21573017 Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function
TXNIP InnateDB 10628 733688 thioredoxin interacting protein thioredoxin interacting protein 22883233 The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy
TET2 InnateDB 54790 100521465 tet methylcytosine dioxygenase 2 tet methylcytosine dioxygenase 2 26287468 A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens
TECPR1 InnateDB 25851 100521257 tectonin beta-propeller repeat containing 1 tectonin beta-propeller repeat containing 1 21575909 Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
TBX21 InnateDB 30009 100518804 T-box transcription factor 21 T-box transcription factor 21 11752460 SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
TBKBP1 InnateDB 9755 100518628 TBK1 binding protein 1 TBK1 binding protein 1 17568778 Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
TAX1BP1 InnateDB 8887 100516165 Tax1 binding protein 1 Tax1 binding protein 1 21765415 The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling
TBK1 InnateDB 29110 100125828 TANK binding kinase 1 TANK binding kinase 1 21820332 TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis
TACR1 InnateDB 6869 110259991 tachykinin receptor 1 tachykinin receptor 1 23365459 Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes
TRAT1 InnateDB 50852 100620198 T cell receptor associated transmembrane adaptor 1 T cell receptor associated transmembrane adaptor 1 21074459 The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells
SNCA InnateDB 6622 641350 synuclein alpha synuclein alpha 21747756 Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation
SDC4 InnateDB 6385 397528 syndecan 4 syndecan 4 22427536 Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense
SNAP23 InnateDB 8773 100512755 synaptosome associated protein 23 synaptosome associated protein 23 18692471 The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
SYP InnateDB 6855 100512029 synaptophysin synaptophysin 7559603 Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection
SMARCE1 InnateDB 6605 100521398 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 17669635 Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation
SMARCA4 InnateDB 6597 102167672 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 19144648 Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation
SMARCA2 InnateDB 6595 100157302 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 19144648 Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation
SFTPD InnateDB 6441 397198 surfactant protein D surfactant protein D 21821801 Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis
SFTPA1 InnateDB 653509 397503 surfactant protein A1 surfactant protein A1 20413160 Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex
SOCS6 InnateDB 9306 100155619 suppressor of cytokine signaling 6 suppressor of cytokine signaling 6 14707129 Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
SOCS5 InnateDB 9655 100302367 suppressor of cytokine signaling 5 suppressor of cytokine signaling 5 15590694 CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
SOCS3 InnateDB 9021 493186 suppressor of cytokine signaling 3 suppressor of cytokine signaling 3 10882725 Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1
SOCS2 InnateDB 8835 100037966 suppressor of cytokine signaling 2 suppressor of cytokine signaling 2 14645718 Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection
SOCS1 InnateDB 8651 100307052 suppressor of cytokine signaling 1 suppressor of cytokine signaling 1 21263070 Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes
SOD1 InnateDB 6647 397036 superoxide dismutase 1 superoxide dismutase 1 26588782 Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling
SENP2 InnateDB 59343 100738022 SUMO specific peptidase 2 SUMO specific peptidase 2 22028379 Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm
SRXN1 InnateDB 140809 100517736 sulfiredoxin 1 sulfiredoxin 1 21466852 Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis
STIM1 InnateDB 6786 100171399 stromal interaction molecule 1 stromal interaction molecule 1 21239714 Activation of STAT6 by STING is critical for antiviral innate immunity
STUB1 InnateDB 10273 100511251 STIP1 homology and U-box containing protein 1 STIP1 homology and U-box containing protein 1 21911421 Down-regulation of Stathmin Is Required for the Phenotypic Changes and Classical Activation of Macrophages
SREBF2 InnateDB 6721 396675 sterol regulatory element binding transcription factor 2 sterol regulatory element binding transcription factor 2 21408089 Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
SREBF1 InnateDB 6720 397308 sterol regulatory element binding transcription factor 1 sterol regulatory element binding transcription factor 1 21531336 A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells
SARM1 InnateDB 23098 100627920 sterile alpha and TIR motif containing 1 sterile alpha and TIR motif containing 1 23499490 Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
STMN1 InnateDB 3925 494463 stathmin 1 stathmin 1 26082487 An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity
SCAF11 InnateDB 9169 100525109 SR-related CTD associated factor 11 SR-related CTD associated factor 11 22895188 Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death
SRC InnateDB 6714 100154503 SRC proto-oncogene, non-receptor tyrosine kinase SRC proto-oncogene, non-receptor tyrosine kinase 19667404 Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
SPON2 InnateDB 10417 110262033 spondin 2 spondin 2 20205276 The identification of a new role for LEKTI in the skin: The use of protein 'bait' arrays to detect defective trafficking of dermcidin in the skin of patients with Netherton syndrome
SF3A1 InnateDB 10291 100154850 splicing factor 3a subunit 1 splicing factor 3a subunit 1 25658809 Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
SYK InnateDB 6850 100125540 spleen associated tyrosine kinase spleen associated tyrosine kinase 26032420 SGT1 is essential for Nod1 activation
SPI1 InnateDB 6688 414912 Spi-1 proto-oncogene Spi-1 proto-oncogene 20510871 Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes
S1PR1 InnateDB 1901 100621202 sphingosine-1-phosphate receptor 1 sphingosine-1-phosphate receptor 1 25024218 An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity
SPHK1 InnateDB 8877 100519210 sphingosine kinase 1 sphingosine kinase 1 20634980 Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
SMPDL3B InnateDB 27293 100514109 sphingomyelin phosphodiesterase acid like 3B sphingomyelin phosphodiesterase acid like 3B 26095358 Cellular transcription modulator SMARCE1 binds to HBV core promoter containing naturally occurring deletions and represses viral replication
SKP2 InnateDB 6502 100329128 S-phase kinase associated protein 2 S-phase kinase associated protein 2 27194766 Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis
SNX27 InnateDB 81609 100516009 sorting nexin 27 sorting nexin 27 17577583 α-Synuclein Alters Toll-Like Receptor Expression
SLC22A3 InnateDB 6581 100142677 solute carrier family 22 member 3 solute carrier family 22 member 3 25561729 Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
SLC15A4 InnateDB 121260 100623262 solute carrier family 15 member 4 solute carrier family 15 member 4 21045126 Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background
SLC11A1 InnateDB 6556 396764 solute carrier family 11 member 1 solute carrier family 11 member 1 25350459 The SLAM and SAP gene families control innate and adaptive immune responses
SCN5A InnateDB 6331 100152567 sodium voltage-gated channel alpha subunit 5 sodium voltage-gated channel alpha subunit 5 25368329 Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
SMAD7 InnateDB 4092 100521305 SMAD family member 7 SMAD family member 7 12589052 Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1
SMAD6 InnateDB 4091 100152069 SMAD family member 6 SMAD family member 6 16951688 Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs
SMAD4 InnateDB 4089 397142 SMAD family member 4 SMAD family member 4 25410655 MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2
SMAD3 InnateDB 4088 397260 SMAD family member 3 SMAD family member 3 25410655 MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2
SLX4 InnateDB 84464 100515719 SLX4 structure-specific endonuclease subunit SLX4 structure-specific endonuclease subunit 24412650 A solute carrier family 22 member 3 variant rs3088442 G→A associated with coronary heart disease inhibits lipopolysaccharide-induced inflammatory response
SLAMF9 InnateDB 89886 100516263 SLAM family member 9 SLAM family member 9 18501771 Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
SLAMF8 InnateDB 56833 100514958 SLAM family member 8 SLAM family member 8 18501771 Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
SLAMF6 InnateDB 114836 100156912 SLAM family member 6 SLAM family member 6 18501771 Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
SIVA1 InnateDB 10572 110258343 SIVA1 apoptosis inducing factor SIVA1 apoptosis inducing factor 19584092 NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance
SIRT1 InnateDB 23411 751859 sirtuin 1 sirtuin 1 21245135 Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst
SIGIRR InnateDB 59307 100626800 single Ig and TIR domain containing single Ig and TIR domain containing 12925853 Stress-induced decrease in TRAF2 stability is mediated by Siah2
SLAMF1 InnateDB 6504 100511325 signaling lymphocytic activation molecule family member 1 signaling lymphocytic activation molecule family member 1 18501771 Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
STAP2 InnateDB 55620 100523772 signal transducing adaptor family member 2 signal transducing adaptor family member 2 18573890 Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages
STAT6 InnateDB 6778 100153518 signal transducer and activator of transcription 6 signal transducer and activator of transcription 6 22000020 IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts
STAT5B InnateDB 6777 397340 signal transducer and activator of transcription 5B signal transducer and activator of transcription 5B 9398404 STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection
STAT5A InnateDB 6776 397550 signal transducer and activator of transcription 5A signal transducer and activator of transcription 5A 9398404 STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection
STAT4 InnateDB 6775 397261 signal transducer and activator of transcription 4 signal transducer and activator of transcription 4 15356157 STAT3 negatively regulates type I IFN-mediated antiviral response
STAT3 InnateDB 6774 733648 signal transducer and activator of transcription 3 signal transducer and activator of transcription 3 21810606 STAT2-dependent induction of RNA adenosine deaminase ADAR1 by type I interferon differs between mouse and human cells in the requirement for STAT1
STAT2 InnateDB 6773 396923 signal transducer and activator of transcription 2 signal transducer and activator of transcription 2 26335850 Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection
STAT1 InnateDB 6772 396655 signal transducer and activator of transcription 1 signal transducer and activator of transcription 1 22065572 Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection
SIRPA InnateDB 140885 494566 signal regulatory protein alpha signal regulatory protein alpha 25538234 Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity
SPPL3 InnateDB 121665 100154995 signal peptide peptidase like 3 signal peptide peptidase like 3 26851218 Intracellular osteopontin (iOPN) and immunity
SIGLEC5 InnateDB 8778 100514653 sialic acid binding Ig like lectin 5 sialic acid binding Ig like lectin 5 17562860 Sialoside-based pattern recognitions discriminating infections from tissue injuries
SIGLEC15 InnateDB 284266 100518460 sialic acid binding Ig like lectin 15 sialic acid binding Ig like lectin 15 21208791 Sialoside-based pattern recognitions discriminating infections from tissue injuries
SIGLEC11 InnateDB 114132 100523848 sialic acid binding Ig like lectin 11 sialic acid binding Ig like lectin 11 21208791 Sialoside-based pattern recognitions discriminating infections from tissue injuries
SIGLEC1 InnateDB 6614 397623 sialic acid binding Ig like lectin 1 sialic acid binding Ig like lectin 1 21208791 Sialoside-based pattern recognitions discriminating infections from tissue injuries
SIAH2 InnateDB 6478 100622531 siah E3 ubiquitin protein ligase 2 siah E3 ubiquitin protein ligase 2 12411493 Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling
SIAH1 InnateDB 6477 100520614 siah E3 ubiquitin protein ligase 1 siah E3 ubiquitin protein ligase 1 11742346 Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
SHARPIN InnateDB 81858 100526216 SHANK associated RH domain interactor SHANK associated RH domain interactor 21709223 The SLAM and SAP gene families control innate and adaptive immune responses
SH2D1A InnateDB 4068 780420 SH2 domain containing 1A SH2 domain containing 1A 18501771 Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
SUGT1 InnateDB 10910 100736854 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 17420470 E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}
SERPINB9 InnateDB 5272 100126851 serpin family B member 9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 22167597 The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2
SERPING1 InnateDB 710 100144304 serpin family G member 1 serpin family G member 1 17709141 PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice
SERPINE1 InnateDB 5054 396945 serpin family E member 1 serpin family E member 1 21768189 SerpinB9 expression in human renal tubular epithelial cells is induced by triggering of the viral dsRNA sensors TLR3, MDA5 and RIG-I
SERPINB2 InnateDB 5055 100519286 serpin family B member 2 serpin family B member 2 23472114 SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation
SPINK5 InnateDB 11005 100512160 serine peptidase inhibitor Kazal type 5 serine peptidase inhibitor Kazal type 5 22588119 The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner
SQSTM1 InnateDB 8878 100518718 sequestosome 1 sequestosome 1 21220332 NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3
SEMA3A InnateDB 10371 100620398 semaphorin 3A semaphorin 3A 21098092 Plasma PLTP (phospholipid-transfer protein): an emerging role in 'reverse lipopolysaccharide transport' and innate immunity
SELE InnateDB 6401 397508 selectin E selectin E 9006914 Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide
SCAMP5 InnateDB 192683 100156508 secretory carrier membrane protein 5 secretory carrier membrane protein 5 19234194 Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
SPP1 InnateDB 6696 397087 secreted phosphoprotein 1 secreted phosphoprotein 1 21136203 Mindin is upregulated during colitis and may activate NF-kappaB in a TLR-9 mediated manner
SCARF1 InnateDB 8578 100623100 scavenger receptor class F member 1 scavenger receptor class F member 1 19237602 Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages
SCARB1 InnateDB 949 397018 scavenger receptor class B member 1 scavenger receptor class B member 1 22589557 Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery
SAMHD1 InnateDB 25939 100154500 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 21720370 Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity
S100A9 InnateDB 6280 100127489 S100 calcium binding protein A9 S100 calcium binding protein A9 21239714 Activation of STAT6 by STING is critical for antiviral innate immunity
S100A8 InnateDB 6279 100127488 S100 calcium binding protein A8 S100 calcium binding protein A8 21239714 Activation of STAT6 by STING is critical for antiviral innate immunity
S100A12 InnateDB 6283 100301483 S100 calcium binding protein A12 S100 calcium binding protein A12 25964473 Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2
S100A10 InnateDB 6281 100515138 S100 calcium binding protein A10 S100 calcium binding protein A10 21115493 Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression
RUNX3 InnateDB 864 100622884 RUNX family transcription factor 3 RUNX family transcription factor 3 16164020 IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction
RUSC1 InnateDB 23623 100156361 RUN and SH3 domain containing 1 RUN and SH3 domain containing 1 19365808 RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters
RICTOR InnateDB 253260 100519575 RPTOR independent companion of MTOR complex 2 RPTOR independent companion of MTOR complex 2 22045807 MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb
POLR2F InnateDB 5435 100737214 RNA polymerase II, I and III subunit F RNA polymerase II, I and III subunit F 23994473 Tripartite-motif proteins and innate immune regulation
RNF5 InnateDB 6048 100144528 ring finger protein 5 ring finger protein 5 19285439 The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
RNF41 InnateDB 10193 100157936 ring finger protein 41 ring finger protein 41 19483718 Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
RNF135 InnateDB 84282 100522211 ring finger protein 135 ring finger protein 135 23950712 Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
RNF125 InnateDB 54941 100517591 ring finger protein 125 ring finger protein 125 17460044 New insights into the role of RNase L in innate immunity
RPS6KA5 InnateDB 9252 100623751 ribosomal protein S6 kinase A5 ribosomal protein S6 kinase A5 18690222 The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
RPS6KA4 InnateDB 8986 100626270 ribosomal protein S6 kinase A4 ribosomal protein S6 kinase A4 18690222 The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
RPS19 InnateDB 6223 100518254 ribosomal protein S19 ribosomal protein S19 19155217 Ribosomal Protein L19 and L22 Modulate TLR3 Signaling
RPL19 InnateDB 6143 396989 ribosomal protein L19 ribosomal protein L19 21860608 Gata3 drives development of RORγt+ group 3 innate lymphoid cells
RNASEL InnateDB 6041 100048946 ribonuclease L ribonuclease L 21190483 New insights into the role of RNase L in innate immunity
RHBDF2 InnateDB 79651 100517601 rhomboid 5 homolog 2 rhomboid 5 homolog 2 22550345 RGS2 is a negative regulator of STAT3-mediated Nox1 expression
ARHGAP15 InnateDB 55843 100520808 Rho GTPase activating protein 15 Rho GTPase activating protein 15 21551229 The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions
RXRA InnateDB 6256 397306 retinoid X receptor alpha retinoid X receptor alpha 20498053 NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein
RARRES2 InnateDB 5919 100141314 retinoic acid receptor responder 2 retinoic acid receptor responder 2 21715684 RanBPM, a scaffolding protein in the immune and nervous systems
RCOR1 InnateDB 23186 100155804 REST corepressor 1 REST corepressor 1 20798038 RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells
RETNLB InnateDB 84666 100037943 resistin like beta resistin like beta 10921885 Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus
RGMB InnateDB 285704 100737299 repulsive guidance molecule BMP co-receptor b repulsive guidance molecule BMP co-receptor b 21187450 Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation
RELB InnateDB 5971 100622609 RELB proto-oncogene, NF-kB subunit RELB proto-oncogene, NF-kB subunit 21419662 Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses
RELA InnateDB 5970 100135665 RELA proto-oncogene, NF-kB subunit RELA proto-oncogene, NF-kB subunit 21209118 Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages
REL InnateDB 5966 100525104 REL proto-oncogene, NF-kB subunit REL proto-oncogene, NF-kB subunit 25565375 REG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum
RGS2 InnateDB 5997 733670 regulator of G protein signaling 2 regulator of G protein signaling 2 22120521 Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages
RCAN1 InnateDB 1827 100511902 regulator of calcineurin 1 regulator of calcineurin 1 19716405 Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
REG3G InnateDB 130120 100240745 regenerating family member 3 gamma regenerating islet-derived 3 gamma 24345802 Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus
RAG1 InnateDB 5896 397506 recombination activating 1 recombination activating 1 21746813 RAD23A negatively regulates RIG-I/MDA5 signaling through promoting TRAF2 polyubiquitination and degradation
RIPK3 InnateDB 11035 100153263 receptor interacting serine/threonine kinase 3 receptor interacting serine/threonine kinase 3 22123964 Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity
RIPK2 InnateDB 8767 100518835 receptor interacting serine/threonine kinase 2 receptor interacting serine/threonine kinase 2 21236705 Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation
RIPK1 InnateDB 8737 100524751 receptor interacting serine/threonine kinase 1 receptor interacting serine/threonine kinase 1 16543241 Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1
REST InnateDB 5978 100520754 RE1 silencing transcription factor RE1 silencing transcription factor 20798038 RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells
RB1 InnateDB 5925 100151828 RB transcriptional corepressor 1 RB transcriptional corepressor 1 22310660 Early endosome localization and activity of RasGEF1b, a toll-like receptor-inducible Ras guanine-nucleotide exchange factor
RASGEF1B InnateDB 153020 100337671 RasGEF domain family member 1B RasGEF domain family member 1B 20090772 Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins
RHEB InnateDB 6009 100516050 Ras homolog, mTORC1 binding Ras homolog, mTORC1 binding 24130493 iRhom2 is required for the secretion of mouse TNFα
RORC InnateDB 6097 100622477 RAR related orphan receptor C RAR related orphan receptor C 24419270 Transcription factor RORα is critical for nuocyte development
RORA InnateDB 6095 100156637 RAR related orphan receptor A RAR related orphan receptor A 22267218 The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA
RBCK1 InnateDB 10616 100519985 RANBP2-type and C3HC4-type zinc finger containing 1 RANBP2-type and C3HC4-type zinc finger containing 1 19136968 Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells
RANBP9 InnateDB 10048 100153339 RAN binding protein 9 RAN binding protein 9 18040864 B cells enhance early innate immune responses during bacterial sepsis
RFTN1 InnateDB 23180 100155924 raftlin, lipid raft linker 1 raftlin, lipid raft linker 1 21266579 FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family
RSAD2 InnateDB 91543 396752 radical S-adenosyl methionine domain containing 2 radical S-adenosyl methionine domain containing 2 20308629 The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
RAD23A InnateDB 5886 100524483 RAD23 homolog A, nucleotide excision repair protein RAD23 homolog A, nucleotide excision repair protein 23357418 A chromatin remodelling complex that loads cohesin onto human chromosomes
RAD21 InnateDB 5885 100738633 RAD21 cohesin complex component RAD21 cohesin complex component 12198550 Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway
RAC2 InnateDB 5880 100621675 Rac family small GTPase 2 Rac family small GTPase 2 22018470 CD81 controls immunity to Listeria infection through rac-dependent inhibition of proinflammatory mediator release and activation of cytotoxic T cells
RAC1 InnateDB 5879 100627149 Rac family small GTPase 1 Rac family small GTPase 1 25972472 Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
RAB8A InnateDB 4218 100511006 RAB8A, member RAS oncogene family RAB8A, member RAS oncogene family 25022365 Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity
RAB11A InnateDB 8766 595117 RAB11A, member RAS oncogene family RAB11A, member RAS oncogene family 20933442 Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection
PKLR InnateDB 5313 100738344 pyruvate kinase L/R pyruvate kinase L/R 22022264 Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity
P2RY14 InnateDB 9934 100524220 purinergic receptor P2Y14 purinergic receptor P2Y14 22778393 The human P2X7 receptor and its role in innate immunity
P2RX7 InnateDB 5027 497623 purinergic receptor P2X 7 purinergic receptor P2X 7 21988719 NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling
PURA InnateDB 5813 100625926 purine rich element binding protein A purine rich element binding protein A 22835829 PTX3, a key component of innate immunity, is induced by SAA via FPRL1-mediated signaling in HAECs
PTMA InnateDB 5757 100294684 prothymosin alpha prothymosin alpha 15242774 Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling
PRTN3 InnateDB 5657 106509464 proteinase 3 proteinase 3 24129891 Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages
PTPRC InnateDB 5788 100522631 protein tyrosine phosphatase receptor type C protein tyrosine phosphatase receptor type C 11201744 Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase
PTPN6 InnateDB 5777 100171389 protein tyrosine phosphatase non-receptor type 6 protein tyrosine phosphatase non-receptor type 6 25876760 Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells
PTPN2 InnateDB 5771 100171401 protein tyrosine phosphatase non-receptor type 2 protein tyrosine phosphatase non-receptor type 2 14600148 Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst
PTPN11 InnateDB 5781 100170851 protein tyrosine phosphatase non-receptor type 11 protein tyrosine phosphatase non-receptor type 11 25538234 Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity
PTK2B InnateDB 2185 100157507 protein tyrosine kinase 2 beta protein tyrosine kinase 2 beta 10228162 Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells
PTK2 InnateDB 5747 102167153 protein tyrosine kinase 2 protein tyrosine kinase 2 18353772 Antiinflammatory effect of lactic acid bacteria: inhibition of cyclooxygenase-2 by suppressing nuclear factor-kappaB in Raw264.7 macrophage cells
PROS1 InnateDB 5627 397388 protein S protein S 22043818 Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages
PPP4C InnateDB 5531 110260085 protein phosphatase 4 catalytic subunit protein phosphatase 4 catalytic subunit 26363053 The calcineurin B subunit (CnB) is a new ligand of integrin αM that mediates CnB-induced Apo2L/TRAIL expression in macrophages
PPP3R1 InnateDB 5534 100627903 protein phosphatase 3 regulatory subunit B, alpha protein phosphatase 3 regulatory subunit B, alpha 22116828 Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization
PPP3CA InnateDB 5530 397241 protein phosphatase 3 catalytic subunit alpha protein phosphatase 3 catalytic subunit alpha 17965024 Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling
PPP1CC InnateDB 5501 733612 protein phosphatase 1 catalytic subunit gamma protein phosphatase 1 catalytic subunit gamma 23499489 Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling
PPP1CA InnateDB 5499 733611 protein phosphatase 1 catalytic subunit alpha protein phosphatase 1 catalytic subunit alpha 23499489 Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling
PRKDC InnateDB 5591 100156379 protein kinase, DNA-activated, catalytic subunit protein kinase, DNA-activated, catalytic subunit 24098118 Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity
PRKX InnateDB 5613 106504268 protein kinase X-linked protein kinase X-linked 25028512 The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8
PKN1 InnateDB 5585 100515528 protein kinase N1 protein kinase N1 18429822 Hepatitis C virus reveals a novel early control in acute immune response
PRKACA InnateDB 5566 397652 protein kinase cAMP-activated catalytic subunit alpha protein kinase cAMP-activated catalytic subunit alpha 25028512 The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8
PRKCE InnateDB 5581 100524932 protein kinase C epsilon protein kinase C epsilon 19150425 Syk kinase-coupled C-type lectin receptors engage protein kinase C-δ to elicit Card9 adaptor-mediated innate immunity
PRKCD InnateDB 5580 100622955 protein kinase C delta protein kinase C delta 22265677 PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells
PACSIN1 InnateDB 29993 100157037 protein kinase C and casein kinase substrate in neurons 1 protein kinase C and casein kinase substrate in neurons 1 22488361 GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity
PRKCA InnateDB 5578 397184 protein kinase C alpha protein kinase C alpha 19950169 Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX)
PIAS4 InnateDB 51588 100624971 protein inhibitor of activated STAT 4 protein inhibitor of activated STAT 4 21199872 miRNA-21 inhibition enhances RANTES and IP-10 release in MCF-7 via PIAS3 and STAT3 signalling and causes increased lymphocyte migration
PIAS3 InnateDB 10401 100511878 protein inhibitor of activated STAT 3 protein inhibitor of activated STAT 3 23998932 SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation
PIAS2 InnateDB 9063 100627995 protein inhibitor of activated STAT 2 protein inhibitor of activated STAT 2 12764129 PIAS proteins promote SUMO-1 conjugation to STAT1
PIAS1 InnateDB 8554 100519005 protein inhibitor of activated STAT 1 protein inhibitor of activated STAT 1 12855578 Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system
PROCR InnateDB 10544 654289 protein C receptor protein C receptor 20543103 PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling
PRMT1 InnateDB 3276 100286877 protein arginine methyltransferase 1 protein arginine methyltransferase 1 19136629 Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice
PRKRA InnateDB 8575 100155653 protein activator of interferon induced protein kinase EIF2AK2 protein activator of interferon induced protein kinase EIF2AK2 25784705 A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus
PSMB8 InnateDB 5696 396975 proteasome 20S subunit beta 8 proteasome 20S subunit beta 8 23527234 Negative regulation of MAVS-mediated innate immune response by PSMA7
PSMA7 InnateDB 5688 100626738 proteasome 20S subunit alpha 7 proteasome 20S subunit alpha 7 19734229 Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness
PTGS2 InnateDB 5743 397590 prostaglandin-endoperoxide synthase 2 prostaglandin-endoperoxide synthase 2 18955820 Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages
PTGES2 InnateDB 80142 100155133 prostaglandin E synthase 2 prostaglandin E synthase 2 21247892 Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
PTGES InnateDB 9536 654407 prostaglandin E synthase prostaglandin E synthase 21497116 PTEN regulates natural killer cell trafficking in vivo
PSTPIP1 InnateDB 9051 100152628 proline-serine-threonine phosphatase interacting protein 1 proline-serine-threonine phosphatase interacting protein 1 17964261 Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice
PRL InnateDB 5617 396965 prolactin prolactin 25049387 Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX)
PDCD1LG2 InnateDB 80380 574057 programmed cell death 1 ligand 2 programmed cell death 1 ligand 2 21097698 IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity
PDCD1 InnateDB 5133 100533201 programmed cell death 1 programmed cell death 1 21263073 Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS)
PSEN2 InnateDB 5664 780410 presenilin 2 presenilin 2 26081153 IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis
PRDM1 InnateDB 639 100154284 PR/SET domain 1 PR/SET domain 1 24477914 PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1
PPARGC1B InnateDB 133522 100329221 PPARG coactivator 1 beta PPARG coactivator 1 beta 21966468 A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis
PPARGC1A InnateDB 10891 397013 PPARG coactivator 1 alpha PPARG coactivator 1 alpha 21966468 A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis
KCNJ8 InnateDB 3764 100152631 potassium inwardly rectifying channel subfamily J member 8 potassium inwardly rectifying channel subfamily J member 8 21719711 The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness
PQBP1 InnateDB 10084 100620849 polyglutamine binding protein 1 polyglutamine binding protein 1 26046437 Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1
PCBP2 InnateDB 5094 397665 poly(rC) binding protein 2 poly(rC) binding protein 2 22105485 Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS)
PCBP1 InnateDB 5093 100511501 poly(rC) binding protein 1 poly(rC) binding protein 1 22105485 Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS)
PLK1 InnateDB 5347 396953 polo like kinase 1 polo like kinase 1 18957422 Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity
PML InnateDB 5371 100157336 PML nuclear body scaffold PML nuclear body scaffold 21131187 Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa
PLXNA4 InnateDB 91584 100620243 plexin A4 plexin A4 21098092 Plasma PLTP (phospholipid-transfer protein): an emerging role in 'reverse lipopolysaccharide transport' and innate immunity
PLEC InnateDB 5339 110260403 plectin plectin 21665277 Phospholipase Cγ-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation
PTAFR InnateDB 5724 100523973 platelet activating factor receptor platelet activating factor receptor 11309383 Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
PLAUR InnateDB 5329 100521017 plasminogen activator, urokinase receptor plasminogen activator, urokinase receptor 21998707 A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages
PLG InnateDB 5340 733660 plasminogen plasminogen 21464960 Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands
PLTP InnateDB 5360 397527 phospholipid transfer protein phospholipid transfer protein 21787334 Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
PLSCR1 InnateDB 5359 100620055 phospholipid scramblase 1 phospholipid scramblase 1 22453241 Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1
PLCG2 InnateDB 5336 100518663 phospholipase C gamma 2 phospholipase C gamma 2 22158869 The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils
PLA2G4A InnateDB 5321 100520687 phospholipase A2 group IVA phospholipase A2 group IVA 22003202 Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes
PLA2G2A InnateDB 5320 100738064 phospholipase A2 group IIA phospholipase A2 group IIA 26644377 Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1
PIK3R1 InnateDB 5295 100623707 phosphoinositide-3-kinase regulatory subunit 1 phosphoinositide-3-kinase regulatory subunit 1 17827709 Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
PIK3AP1 InnateDB 118788 100155165 phosphoinositide-3-kinase adaptor protein 1 phosphoinositide-3-kinase adaptor protein 1 20728433 PIASy inhibits virus-induced and interferon-stimulated transcription through distinct mechanisms
PDE12 InnateDB 201626 100157651 phosphodiesterase 12 phosphodiesterase 12 26055709 Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10
PIK3CG InnateDB 5294 396979 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 25022365 Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity
PIK3CD InnateDB 5293 100518131 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta 27194783 The p110α and p110β isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells
PIK3CB InnateDB 5291 100622559 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta 20953381 Role of phosphoinositide 3-kinase in innate immunity
PIK3CA InnateDB 5290 100621789 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha 17827709 Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
PIK3C3 InnateDB 5289 503700 phosphatidylinositol 3-kinase catalytic subunit type 3 phosphatidylinositol 3-kinase catalytic subunit type 3 22170068 Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics
PTEN InnateDB 5728 100156264 phosphatase and tensin homolog phosphatase and tensin homolog 25646418 Novel regulators of the systemic response to lipopolysaccharide
PMAIP1 InnateDB 5366 397278 phorbol-12-myristate-13-acetate-induced protein 1 phorbol-12-myristate-13-acetate-induced protein 1 21698224 Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm
PPARG InnateDB 5468 397671 peroxisome proliferator activated receptor gamma peroxisome proliferator activated receptor gamma 21148557 Extensive cooperation of immune master regulators IRF3 and NFκB in RNA Pol II recruitment and pause release in human innate antiviral transcription
PPIA InnateDB 5478 397637 peptidylprolyl isomerase A peptidylprolyl isomerase A 20829794 A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis
PIN1 InnateDB 5300 100512827 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 21743479 Role of phosphoinositide 3-kinase in innate immunity
PADI4 InnateDB 23569 100524749 peptidyl arginine deiminase 4 peptidyl arginine deiminase 4 20733033 PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells
PGLYRP4 InnateDB 57115 396556 peptidoglycan recognition protein 4 peptidoglycan recognition protein 4 21439073 Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system
PGLYRP3 InnateDB 114771 100626786 peptidoglycan recognition protein 3 peptidoglycan recognition protein 3 21439073 Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system
PGLYRP2 InnateDB 114770 396557 peptidoglycan recognition protein 2 peptidoglycan recognition protein 2 21439073 Evolutionary origin of peptidoglycan recognition proteins in vertebrate innate immune system
PGLYRP1 InnateDB 8993 397213 peptidoglycan recognition protein 1 peptidoglycan recognition protein 1 21134971 Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling
PTX3 InnateDB 5806 100513178 pentraxin 3 pentraxin 3 21465531 CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
PELI3 InnateDB 246330 100519073 pellino E3 ubiquitin protein ligase family member 3 pellino E3 ubiquitin protein ligase family member 3 26310831 The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1
PELI2 InnateDB 57161 100152019 pellino E3 ubiquitin protein ligase family member 2 pellino E3 ubiquitin protein ligase family member 2 17997719 Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS
PELI1 InnateDB 57162 100627613 pellino E3 ubiquitin protein ligase 1 pellino E3 ubiquitin protein ligase 1 26131354 The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors
PTCH1 InnateDB 5727 100627504 patched 1 patched 1 21131441 Novel regulators of the systemic response to lipopolysaccharide
PARD3 InnateDB 56288 100512009 par-3 family cell polarity regulator par-3 family cell polarity regulator 24244864 PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
OTUB2 InnateDB 78990 100151873 OTU deubiquitinase, ubiquitin aldehyde binding 2 OTU deubiquitinase, ubiquitin aldehyde binding 2 19996094 Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia
OTUB1 InnateDB 55611 100302092 OTU deubiquitinase, ubiquitin aldehyde binding 1 OTU deubiquitinase, ubiquitin aldehyde binding 1 19996094 Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia
OTUD7B InnateDB 56957 100152569 OTU deubiquitinase 7B OTU deubiquitinase 7B 18178551 DUBA: a deubiquitinase that regulates type I interferon production
OTUD5 InnateDB 55593 100624053 OTU deubiquitinase 5 OTU deubiquitinase 5 17991829 Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6
OPTN InnateDB 10133 397011 optineurin optineurin 20174559 Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice
OSM InnateDB 5008 100152038 oncostatin M oncostatin M 25692402 β-Defensin 1 plays a role in acute mucosal defense against Candida albicans
OLFM4 InnateDB 10562 100737320 olfactomedin 4 olfactomedin 4 22844115 New insights into the role of RNase L in innate immunity
NUMBL InnateDB 9253 100627312 NUMB like endocytic adaptor protein NUMB like endocytic adaptor protein 18299187 NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease
NUMB InnateDB 8650 100522019 NUMB endocytic adaptor protein NUMB endocytic adaptor protein 24092752 The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
NOD2 InnateDB 64127 100125838 nucleotide binding oligomerization domain containing 2 nucleotide binding oligomerization domain containing 2 18981137 Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway
NOD1 InnateDB 10392 100135660 nucleotide binding oligomerization domain containing 1 nucleotide binding oligomerization domain containing 1 17705131 NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways
NXN InnateDB 64359 100523510 nucleoredoxin nucleoredoxin 20400501 Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1
NUP214 InnateDB 8021 100155564 nucleoporin 214 nucleoporin 214 15210729 Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1
NUP153 InnateDB 9972 100153581 nucleoporin 153 nucleoporin 153 15210729 Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1
NR4A3 InnateDB 8013 397479 nuclear receptor subfamily 4 group A member 3 nuclear receptor subfamily 4 group A member 3 21492741 Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes
NR3C1 InnateDB 2908 396740 nuclear receptor subfamily 3 group C member 1 nuclear receptor subfamily 3 group C member 1 21750107 The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation
NR1H4 InnateDB 9971 100153960 nuclear receptor subfamily 1 group H member 4 nuclear receptor subfamily 1 group H member 4 23372731 Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: implication to interferon production
NR1H3 InnateDB 10062 397553 nuclear receptor subfamily 1 group H member 3 nuclear receptor subfamily 1 group H member 3 21492741 Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes
NRIP1 InnateDB 8204 106505834 nuclear receptor interacting protein 1 nuclear receptor interacting protein 1 22388040 Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation
NFIL3 InnateDB 4783 100153822 nuclear factor, interleukin 3 regulated nuclear factor, interleukin 3 regulated 21383239 NFI-A disrupts myeloid cell differentiation and maturation in septic mice
NFAT5 InnateDB 10725 100516737 nuclear factor of activated T cells 5 nuclear factor of activated T cells 5 20685965 Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling
NFATC4 InnateDB 4776 100154469 nuclear factor of activated T cells 4 nuclear factor of activated T cells 4 21726630 Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages
NFATC3 InnateDB 4775 100739450 nuclear factor of activated T cells 3 nuclear factor of activated T cells 3 21726630 Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages
NFATC2 InnateDB 4773 100134969 nuclear factor of activated T cells 2 nuclear factor of activated T cells 2 20557936 Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity
NFKB2 InnateDB 4791 100153829 nuclear factor kappa B subunit 2 nuclear factor kappa B subunit 2 26026270 The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50
NFKB1 InnateDB 4790 751869 nuclear factor kappa B subunit 1 nuclear factor kappa B subunit 1 21343618 NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity
NFIA InnateDB 4774 100523676 nuclear factor I A nuclear factor I A 26259914 Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
NRAS InnateDB 4893 100739349 NRAS proto-oncogene, GTPase NRAS proto-oncogene, GTPase 21757746 Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: implication to interferon production
NOTCH1 InnateDB 4851 110258061 notch receptor 1 notch receptor 1 21737799 Increases in calmodulin abundance and stabilization of activated inducible nitric oxide synthase mediate bacterial killing in RAW 264.7 macrophages
NLRP9 InnateDB 338321 100519960 NLR family pyrin domain containing 9 NLR family pyrin domain containing 9 18648497 The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
NLRP8 InnateDB 126205 100521197 NLR family pyrin domain containing 8 NLR family pyrin domain containing 8 18648497 The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
NLRP6 InnateDB 171389 100519245 NLR family pyrin domain containing 6 NLR family pyrin domain containing 6 22763455 Expression analysis of the NLRP gene family suggests a role in human preimplantation development
NLRP5 InnateDB 126206 100170773 NLR family pyrin domain containing 5 NLR family pyrin domain containing 5 18648497 The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
NLRP4 InnateDB 147945 100739064 NLR family pyrin domain containing 4 NLR family pyrin domain containing 4 15107016 The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
NLRP3 InnateDB 114548 100514823 NLR family pyrin domain containing 3 NLR family pyrin domain containing 3 19362020 NLRP2, an inhibitor of the NF-kappaB pathway, is transcriptionally activated by NF-kappaB and exhibits a nonfunctional allelic variant
NLRP2 InnateDB 55655 100737181 NLR family pyrin domain containing 2 NLR family pyrin domain containing 2 18056399 Expression analysis of the NLRP gene family suggests a role in human preimplantation development
NLRP14 InnateDB 338323 100622523 NLR family pyrin domain containing 14 NLR family pyrin domain containing 14 18648497 The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
NLRP13 InnateDB 126204 100521019 NLR family pyrin domain containing 13 NLR family pyrin domain containing 13 18648497 The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
NLRP12 InnateDB 91662 100523066 NLR family pyrin domain containing 12 NLR family pyrin domain containing 12 25888258 Expression analysis of the NLRP gene family suggests a role in human preimplantation development
NLRP11 InnateDB 204801 100622339 NLR family pyrin domain containing 11 NLR family pyrin domain containing 11 18648497 The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
NLRP1 InnateDB 22861 110256098 NLR family pyrin domain containing 1 NLR family pyrin domain containing 1 18280719 Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch
NLRX1 InnateDB 79671 100518678 NLR family member X1 NLR family member X1 21703540 Expression analysis of the NLRP gene family suggests a role in human preimplantation development
NLRC5 InnateDB 84166 100135667 NLR family CARD domain containing 5 NLR family CARD domain containing 5 26620909 A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans
NLRC4 InnateDB 58484 100515078 NLR family CARD domain containing 4 NLR family CARD domain containing 4 22174673 The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB
NLRC3 InnateDB 197358 100135669 NLR family CARD domain containing 3 NLR family CARD domain containing 3 22863753 Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages
NAIP InnateDB 4671 102164352 NLR family apoptosis inhibitory protein NLR family apoptosis inhibitory protein 18280719 Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch
NOS2 InnateDB 4843 396859 nitric oxide synthase 2 nitric oxide synthase 2 16893173 NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity
NAMPT InnateDB 10135 595123 nicotinamide phosphoribosyltransferase nicotinamide phosphoribosyltransferase 22377803 NLR, the nucleotide-binding domain leucine-rich repeat containing gene family
NFKBIZ InnateDB 64332 100520981 NFKB inhibitor zeta NFKB inhibitor zeta 26287468 A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens
NKIRAS2 InnateDB 28511 100524706 NFKB inhibitor interacting Ras like 2 NFKB inhibitor interacting Ras like 2 20351193 Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras
NKIRAS1 InnateDB 28512 100620195 NFKB inhibitor interacting Ras like 1 NFKB inhibitor interacting Ras like 1 15024091 Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
NFKBIE InnateDB 4794 100153486 NFKB inhibitor epsilon NFKB inhibitor epsilon 11152669 IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
NFKBIB InnateDB 4793 100621111 NFKB inhibitor beta NFKB inhibitor beta 9346485 Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity
NFKBIA InnateDB 4792 406188 NFKB inhibitor alpha NFKB inhibitor alpha 21454695 Innate immunity: Bacterial cell-wall muramyl peptide targets the conserved transcription factor YB-1
NFE2L2 InnateDB 4780 100516343 NFE2 like bZIP transcription factor 2 NFE2 like bZIP transcription factor 2 21220332 NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3
NEU1 InnateDB 4758 100124381 neuraminidase 1 neuraminidase 1 21873432 A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity
NTN1 InnateDB 9423 733599 netrin 1 netrin 1 22231519 NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance
NCKAP1L InnateDB 3071 102162203 NCK associated protein 1 like NCK associated protein 1 like 19015308 Extracellular ATP induces P2X7-dependent nicotinamide phosphoribosyltransferase release in LPS-activated human monocytes
NOXA1 InnateDB 10811 100516894 NADPH oxidase activator 1 NADPH oxidase activator 1 20110267 Oxidative innate immune defenses by Nox/Duox family NADPH oxidases
NOX4 InnateDB 50507 100523323 NADPH oxidase 4 NADPH oxidase 4 18511861 RGS2 is a negative regulator of STAT3-mediated Nox1 expression
NOX1 InnateDB 27035 100739822 NADPH oxidase 1 NADPH oxidase 1 22120521 Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages
MX2 InnateDB 4600 396893 MX dynamin like GTPase 2 myxovirus (influenza virus) resistance 2 (mouse) 18062906 The Mx GTPase family of interferon-induced antiviral proteins
MYH9 InnateDB 4627 396904 myosin heavy chain 9 myosin heavy chain 9 24489676 The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system
MYD88 InnateDB 4615 396646 MYD88 innate immune signal transduction adaptor MYD88 innate immune signal transduction adaptor 20881045 Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice
MYC InnateDB 4609 448810 MYC proto-oncogene, bHLH transcription factor MYC proto-oncogene, bHLH transcription factor 25049387 Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX)
MX1 InnateDB 4599 397128 MX dynamin like GTPase 1 MX dynamin like GTPase 1 18062906 The Mx GTPase family of interferon-induced antiviral proteins
MLST8 InnateDB 64223 100738908 MTOR associated protein, LST8 homolog MTOR associated protein, LST8 homolog 18755269 Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis
MOV10 InnateDB 4343 100521086 Mov10 RISC complex RNA helicase Mov10 RISC complex RNA helicase 23093941 Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling
MAP3K8 InnateDB 1326 100622217 mitogen-activated protein kinase kinase kinase 8 mitogen-activated protein kinase kinase kinase 8 21135874 Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression
MAP3K7 InnateDB 6885 100135663 mitogen-activated protein kinase kinase kinase 7 mitogen-activated protein kinase kinase kinase 7 21220427 Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages
MAP3K5 InnateDB 4217 100622769 mitogen-activated protein kinase kinase kinase 5 mitogen-activated protein kinase kinase kinase 5 21515258 GSK-3β-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock
MAP3K4 InnateDB 4216 100154202 mitogen-activated protein kinase kinase kinase 4 mitogen-activated protein kinase kinase kinase 4 17726008 Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling
MAP3K3 InnateDB 4215 100513491 mitogen-activated protein kinase kinase kinase 3 mitogen-activated protein kinase kinase kinase 3 18206350 Respiratory syncytial virus induces RelA release from cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I{middle dot}NF- kappa B-inducing kinase signaling pathway
MAP3K14 InnateDB 9020 100520402 mitogen-activated protein kinase kinase kinase 14 mitogen-activated protein kinase kinase kinase 14 18550535 Regulation of the CREB coactivator TORC by the dual leucine zipper kinase at different levels
MAP3K12 InnateDB 7786 100517714 mitogen-activated protein kinase kinase kinase 12 mitogen-activated protein kinase kinase kinase 12 20940047 TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway
MAP3K1 InnateDB 4214 396617 mitogen-activated protein kinase kinase kinase 1 mitogen-activated protein kinase kinase kinase 1 18984593 MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infection
MAP2K7 InnateDB 5609 100520418 mitogen-activated protein kinase kinase 7 mitogen-activated protein kinase kinase 7 24651600 Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades
MAP2K6 InnateDB 5608 100625946 mitogen-activated protein kinase kinase 6 mitogen-activated protein kinase kinase 6 9841871 Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1
MAP2K4 InnateDB 6416 100520100 mitogen-activated protein kinase kinase 4 mitogen-activated protein kinase kinase 4 10715136 Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
MAP2K3 InnateDB 5606 110256149 mitogen-activated protein kinase kinase 3 mitogen-activated protein kinase kinase 3 7839144 A novel MEK2/PI3Kδ pathway controls the expression of IL-1 receptor antagonist in IFN-β-activated human monocytes
MAP2K2 InnateDB 5605 100525505 mitogen-activated protein kinase kinase 2 mitogen-activated protein kinase kinase 2 20837746 A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission
MAP2K1 InnateDB 5604 100233191 mitogen-activated protein kinase kinase 1 mitogen-activated protein kinase kinase 1 11134045 LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy
MAPK9 InnateDB 5601 396609 mitogen-activated protein kinase 9 mitogen-activated protein kinase 9 19153595 Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
MAPK8 InnateDB 5599 396610 mitogen-activated protein kinase 8 mitogen-activated protein kinase 8 24185614 Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst
MAPK3 InnateDB 5595 445013 mitogen-activated protein kinase 3 mitogen-activated protein kinase 3 25538234 Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity
MAPK14 InnateDB 1432 100156630 mitogen-activated protein kinase 14 mitogen-activated protein kinase 14 21683629 Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases
MAPK1 InnateDB 5594 100153927 mitogen-activated protein kinase 1 mitogen-activated protein kinase 1 22447027 Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase
MFN2 InnateDB 9927 100512354 mitofusin 2 mitofusin 2 21285412 Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling
MFN1 InnateDB 55669 100627612 mitofusin 1 mitofusin 1 21285412 Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling
MFF InnateDB 56947 100513442 mitochondrial fission factor mitochondrial fission factor 24733894 Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors
MUL1 InnateDB 79594 100514904 mitochondrial E3 ubiquitin protein ligase 1 mitochondrial E3 ubiquitin protein ligase 1 23399697 nodata
COX5B InnateDB 1329 492822 cytochrome c oxidase subunit 5B mitochondrial cytochrome c oxidase subunit Vb 23308066 COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production
MAVS InnateDB 57506 100037290 mitochondrial antiviral signaling protein mitochondrial antiviral signaling protein 21454965 The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection
MFGE8 InnateDB 4240 397545 milk fat globule EGF and factor V/VIII domain containing milk fat globule EGF and factor V/VIII domain containing 23454767 Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence
MID2 InnateDB 11043 100157515 midline 2 midline 2 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
MID1 InnateDB 4281 100524415 midline 1 midline 1 23438823 TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
MAP1LC3C InnateDB 440738 100512852 microtubule associated protein 1 light chain 3 gamma microtubule associated protein 1 light chain 3 gamma 23022382 Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production
MIR497 InnateDB 574456 100498732 microRNA 497 microRNA mir-497 23092882 MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function
MIR362 InnateDB 574030 100526403 microRNA 362 microRNA mir-362 25909817 An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway
MIR342 InnateDB 442909 100498741 microRNA 342 microRNA mir-342 26938778 Resistin-like molecule α promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation
MIR328 InnateDB 442901 100498794 microRNA 328 microRNA mir-328 25894560 MicroRNA-29a promotes apoptosis of monocytes by targeting STAT3 during sepsis
MIR29A InnateDB 407021 100498781 microRNA 29a microRNA mir-29a 26535690 Retinoic acid-inducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through down-regulation of the very low density lipoprotein receptor
MIR23B InnateDB 407011 100498785 microRNA 23b microRNA mir-23b 21642441 The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
MIR23A InnateDB 407010 100316598 microRNA 23a microRNA mir-23a 25461762 NLRP3 inflammasome activity is negatively controlled by miR-223
MIR223 InnateDB 407008 114482249 microRNA 223 microRNA mir-223 22984082 Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212
MIR212 InnateDB 406994 104794437 microRNA 212 microRNA mir-212 23264652 A trio of microRNAs that control Toll-like receptor signalling
MIR21 InnateDB 406991 100316568 microRNA 21 microRNA mir-21 21652514 The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs
MIR208B InnateDB 100126336 100498788 microRNA 208b microRNA mir-208b 24241692 Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo
MIR187 InnateDB 406963 100628336 microRNA 187 microRNA mir-187 23071313 miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene
MIR16-2 InnateDB 406951 100316571 microRNA 16-2 microRNA mir-16-2 22292036 miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene
MIR16-1 InnateDB 406950 100316611 microRNA 16-1 microRNA mir-16-1 22292036 miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene
MIR15B InnateDB 406949 100170411 microRNA 15b microRNA mir-15b 23580661 MicroRNA-149 negatively regulates TLR-triggered inflammatory response in macrophages by targeting MyD88
MIR149 InnateDB 406941 100526400 microRNA 149 microRNA mir-149 24375488 miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1 infection of CD4(+) T lymphocytes
MIR146A InnateDB 406938 100526391 microRNA 146a microRNA mir-146a 25705792 DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA
MIR145 InnateDB 406937 100316550 microRNA 145 microRNA mir-145 23392170 miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12β during murine colitis and human Crohn's disease
MIR141 InnateDB 406933 114483443 microRNA 141 microRNA mir-141 24000293 Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells
MIR136 InnateDB 406927 100316564 microRNA 136 microRNA mir-136 26450567 Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212
MIR132 InnateDB 406921 104794429 microRNA 132 microRNA mir-132 23264652 A trio of microRNAs that control Toll-like receptor signalling
MIR130A InnateDB 406919 100316596 microRNA 130a microRNA mir-130a 25595716 The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids
MIR126 InnateDB 406913 100526399 microRNA 126 microRNA mir-126 24270517 MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection
MIR125A InnateDB 406910 100498718 microRNA 125a microRNA mir-125a 25917095 HSV ICP0 recruits USP7 to modulate TLR-mediated innate response
MIR122 InnateDB 406906 100170404 microRNA 122 microRNA mir-122 23580661 MicroRNA-149 negatively regulates TLR-triggered inflammatory response in macrophages by targeting MyD88
MIR10B InnateDB 406903 100498711 microRNA 10b microRNA mir-10b 22915757 Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40
MIR10A InnateDB 406902 100498783 microRNA 10a microRNA mir-10a 22068236 MicroRNA-467b targets LPL gene in RAW 264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion
MIR107 InnateDB 406901 100170413 microRNA 107 microRNA mir-107 21628465 Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6
MIRLET7C InnateDB 406885 100170412 microRNA let-7c microRNA let-7c 22835429 MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway
MTA1 InnateDB 9112 110258362 metastasis associated 1 metastasis associated 1 20699220 The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity
MERTK InnateDB 10461 100519652 MER proto-oncogene, tyrosine kinase MER proto-oncogene, tyrosine kinase 23954153 A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C)
MEFV InnateDB 4210 100517333 MEFV innate immuity regulator, pyrin MEFV innate immuity regulator, pyrin 126461680 Interactions of ficolin and mannose-binding lectin with fibrinogefibrin augment the lectin complement pathway
MTOR InnateDB 2475 100127359 mechanistic target of rapamycin kinase mechanistic target of rapamycin kinase 21368289 Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1
MASP2 InnateDB 10747 100302537 MBL associated serine protease 2 MBL associated serine protease 2 22792067 Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D
MASP1 InnateDB 5648 100152125 MBL associated serine protease 1 MBL associated serine protease 1 20038603 Autophagy regulates phagocytosis by modulating the expression of scavenger receptors
MMP9 InnateDB 4318 654325 matrix metallopeptidase 9 matrix metallopeptidase 9 21873432 A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity
MMP7 InnateDB 4316 397411 matrix metallopeptidase 7 matrix metallopeptidase 7 19181662 Macrophage elastase kills bacteria within murine macrophages
MMP12 InnateDB 4321 100101475 matrix metallopeptidase 12 matrix metallopeptidase 12 19536155 GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase
MRGPRX2 InnateDB 117194 100736830 MAS related GPR family member X2 MAS related GPR family member X2 22069323 Single-cell analysis reveals new subset markers of murine peritoneal macrophages and highlights macrophage dynamics upon Staphylococcus aureus peritonitis
MKNK1 InnateDB 8569 100233194 MAPK interacting serine/threonine kinase 1 MAPK interacting serine/threonine kinase 1 21149447 Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells
MAPKAPK2 InnateDB 9261 100521986 MAPK activated protein kinase 2 MAPK activated protein kinase 2 21969554 The TAK1-JNK cascade is required for IRF3 function in the innate immune response
MRC1 InnateDB 4360 445003 mannose receptor C-type 1 mannose receptor C-type 1 27220602 TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens
MBL2 InnateDB 4153 397230 mannose binding lectin 2 mannose binding lectin 2 20375621 Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia
MALT1 InnateDB 10892 100153830 MALT1 paracaspase MALT1 paracaspase 18192506 The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
MAFB InnateDB 9935 100518227 MAF bZIP transcription factor B MAF bZIP transcription factor B 20581830 Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a LyPI3K module and promoted by SHIP1
MST1R InnateDB 4486 100626292 macrophage stimulating 1 receptor macrophage stimulating 1 receptor 18684919 Pattern recognition scavenger receptor CD204 attenuates Toll-like receptor 4-induced NF-kappaB activation by directly inhibiting ubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6
MSR1 InnateDB 4481 100511665 macrophage scavenger receptor 1 macrophage scavenger receptor 1 21460221 Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization
MARCO InnateDB 8685 100516298 macrophage receptor with collagenous structure macrophage receptor with collagenous structure 24035364 Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b
MIF InnateDB 4282 397412 macrophage migration inhibitory factor macrophage migration inhibitory factor 17435771 A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection
LPCAT2 InnateDB 54947 100517894 lysophosphatidylcholine acyltransferase 2 lysophosphatidylcholine acyltransferase 2 20663880 Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression
KDM4A InnateDB 9682 100621904 lysine demethylase 4A lysine demethylase 4A 24656046 ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections
KAT2B InnateDB 8850 100626923 lysine acetyltransferase 2B lysine acetyltransferase 2B 10022868 The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription
LYN InnateDB 4067 100152890 LYN proto-oncogene, Src family tyrosine kinase LYN proto-oncogene, Src family tyrosine kinase 20385881 Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes
LTBR InnateDB 4055 100520196 lymphotoxin beta receptor lymphotoxin beta receptor 21767811 Leukotriene B4 augments and restores Fc gammaRs-dependent phagocytosis in macrophages
LCP2 InnateDB 3937 100511843 lymphocyte cytosolic protein 2 lymphocyte cytosolic protein 2 25929249 Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection
LY96 InnateDB 23643 100125555 lymphocyte antigen 96 lymphocyte antigen 96 21712422 The SLAM and SAP gene families control innate and adaptive immune responses
LY9 InnateDB 4063 100155269 lymphocyte antigen 9 lymphocyte antigen 9 18501771 Pulmonary collectins play distinct roles in host defense against Mycobacterium avium
LY86 InnateDB 9450 396639 lymphocyte antigen 86 lymphocyte antigen 86 20534476 Extracellular matrix protein lumican promotes clearance and resolution of Pseudomonas aeruginosa keratitis in a mouse model
LUM InnateDB 4060 100152607 lumican lumican 23358433 Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge
LRRFIP2 InnateDB 9209 100626059 LRR binding FLII interacting protein 2 LRR binding FLII interacting protein 2 21220426 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
LRRFIP1 InnateDB 9208 100517377 LRR binding FLII interacting protein 1 LRR binding FLII interacting protein 1 20453844 Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages
LCN2 InnateDB 3934 100153501 lipocalin 2 lipocalin 2 26190773 Divergent roles of IRAK4-mediated innate immune responses in two experimental models of severe malaria
LAT InnateDB 27040 100517816 linker for activation of T cells linker for activation of T cells 12857726 A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling
LTB4R InnateDB 1241 100157290 leukotriene B4 receptor leukotriene B4 receptor 20959460 LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane
LST1 InnateDB 7940 100522150 leukocyte specific transcript 1 leukocyte specific transcript 1 22589543 The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
LRRK2 InnateDB 120892 780403 leucine rich repeat kinase 2 leucine rich repeat kinase 2 21983832 Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling
LGR4 InnateDB 55366 100518646 leucine rich repeat containing G protein-coupled receptor 4 leucine rich repeat containing G protein-coupled receptor 4 23589304 Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
LEP InnateDB 3952 396832 leptin leptin 23341537 Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets
LGMN InnateDB 5641 100154477 legumain legumain 21402738 Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages
KLF4 InnateDB 9314 595111 Kruppel like factor 4 Kruppel like factor 4 23733190 Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells
KITLG InnateDB 4254 397509 KIT ligand KIT ligand 21262348 Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections
KDR InnateDB 3791 397311 kinase insert domain receptor kinase insert domain receptor 24270517 MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection
KHSRP InnateDB 8570 100516780 KH-type splicing regulatory protein KH-type splicing regulatory protein 21690298 Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
KEAP1 InnateDB 9817 100136900 kelch like ECH associated protein 1 kelch like ECH associated protein 1 24011591 The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids
KPNA1 InnateDB 3836 397235 karyopherin subunit alpha 1 karyopherin subunit alpha 1 16298512 Influence of the kallikrein-kinin system on prostate and breast tumour angiogenesis
KLK1 InnateDB 3816 431673 kallikrein 1 kallikrein 1 18577888 Nitric oxide and KLF4 protein epigenetically modify class II transactivator to repress major histocompatibility complex II expression during Mycobacterium bovis bacillus Calmette-Guerin infection
JAM3 InnateDB 83700 100520043 junctional adhesion molecule 3 junctional adhesion molecule 3 21706006 Hemagglutinin from the H5N1 virus activates Janus kinase 3 to dysregulate innate immunity
JUN InnateDB 3725 396913 Jun proto-oncogene, AP-1 transcription factor subunit Jun proto-oncogene, AP-1 transcription factor subunit 20557936 Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity
JMJD6 InnateDB 23210 100621462 jumonji domain containing 6, arginine demethylase and lysine hydroxylase jumonji domain containing 6, arginine demethylase and lysine hydroxylase 26221041 The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
JAK3 InnateDB 3718 100518649 Janus kinase 3 Janus kinase 3 22359619 JAK2 inhibition prevents innate immune responses and rescues animals from sepsis
JAK2 InnateDB 3717 397201 Janus kinase 2 Janus kinase 2 20393690 Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains
JAK1 InnateDB 3716 397202 Janus kinase 1 Janus kinase 1 8041779 An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity
ISG15 InnateDB 9636 100145895 ISG15 ubiquitin like modifier ISG15 ubiquitin like modifier 22022264 Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity
IREB2 InnateDB 3658 100153993 iron responsive element binding protein 2 iron responsive element binding protein 2 26190773 Divergent roles of IRAK4-mediated innate immune responses in two experimental models of severe malaria
ILF3 InnateDB 3609 100515360 interleukin enhancer binding factor 3 interleukin enhancer binding factor 3 18490444 An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation
IL9 InnateDB 3578 100144594 interleukin 9 interleukin 9 21983833 Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria
IL7R InnateDB 3575 100271930 interleukin 7 receptor interleukin 7 receptor 26187413 Interleukin-7 produced by intestinal epithelial cells in response to Citrobacter rodentium infection plays a major role in innate immunity against this pathogen
IL7 InnateDB 3574 397253 interleukin 7 interleukin 7 26034215 Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
IL6ST InnateDB 3572 100037294 interleukin 6 cytokine family signal transducer interleukin 6 cytokine family signal transducer 10829066 IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
IL6 InnateDB 3569 399500 interleukin 6 interleukin 6 21148800 Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells
IL5 InnateDB 3567 397409 interleukin 5 interleukin 5 24631157 Characterization of an interferon-stimulated response element (ISRE) in the Il23a promoter
IL4R InnateDB 3566 397614 interleukin 4 receptor interleukin 4 receptor 8609418 Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
IL4 InnateDB 3565 397225 interleukin 4 interleukin 4 21566158 Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
IL33 InnateDB 90865 100518643 interleukin 33 interleukin 33 21623379 Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells
IL31 InnateDB 386653 102167534 interleukin 31 interleukin 31 20190140 Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains
IL29 InnateDB 282618 100217388 interferon lambda 1 interleukin 29 (interferon, lambda 1) 21499846 IL-37 is a fundamental inhibitor of innate immunity
IL28B InnateDB 282617 100310828 interferon lambda 3 interleukin 28B (interferon, lambda 3) 24041672 IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes
IL27 InnateDB 246778 493187 interleukin 27 interleukin 27 22156348 Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells
IL23A InnateDB 51561 100155546 interleukin 23 subunit alpha interleukin 23 subunit alpha 21097874 Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection
IL22RA2 InnateDB 116379 100513324 interleukin 22 receptor subunit alpha 2 interleukin 22 receptor subunit alpha 2 25476703 A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
IL22 InnateDB 50616 595104 interleukin 22 interleukin 22 18978771 The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells
IL21 InnateDB 59067 403123 interleukin 21 interleukin 21 23453633 Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member
IL20RB InnateDB 53833 100620875 interleukin 20 receptor subunit beta interleukin 20 receptor subunit beta 24677051 Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member
IL20RA InnateDB 53832 100622457 interleukin 20 receptor subunit alpha interleukin 20 receptor subunit alpha 24677051 Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member
IL2RG InnateDB 3561 397156 interleukin 2 receptor subunit gamma interleukin 2 receptor subunit gamma 8041779 An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity
IL2RB InnateDB 3560 100621776 interleukin 2 receptor subunit beta interleukin 2 receptor subunit beta 26668377 Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity
IL2 InnateDB 3558 396868 interleukin 2 interleukin 2 26187413 Interleukin-7 produced by intestinal epithelial cells in response to Citrobacter rodentium infection plays a major role in innate immunity against this pathogen
IL19 InnateDB 29949 100038024 interleukin 19 interleukin 19 24677051 Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member
IL18R1 InnateDB 8809 397179 interleukin 18 receptor 1 interleukin 18 receptor 1 25654981 Structure of the activating IL-1 receptor signaling complex
IL18 InnateDB 3606 397057 interleukin 18 interleukin 18 22940097 IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens
IL17F InnateDB 112744 100037933 interleukin 17F interleukin 17F 25595775 Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action
IL17C InnateDB 27189 100861588 interleukin 17C interleukin 17C 21993848 Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)
IL17A InnateDB 3605 449530 interleukin 17A interleukin 17A 21822258 IL-15 regulates homeostasis and terminal maturation of NKT cells
IL17RE InnateDB 132014 110255175 interleukin 17 receptor E interleukin 17 receptor E 21993849 Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions
IL17RD InnateDB 54756 100513377 interleukin 17 receptor D interleukin 17 receptor D 25808990 β-Defensin 1 plays a role in acute mucosal defense against Candida albicans
IL15 InnateDB 3600 397683 interleukin 15 interleukin 15 22084435 The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1)
IL13RA1 InnateDB 3597 397615 interleukin 13 receptor subunit alpha 1 interleukin 13 receptor subunit alpha 1 21097505 IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M
IL13 InnateDB 3596 396721 interleukin 13 interleukin 13 22154382 The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation
IL12B InnateDB 3593 397076 interleukin 12B interleukin 12B 22888135 Cutting edge: a novel mechanism bridging innate and adaptive immunity: IL-12 induction of CD25 to form high-affinity IL-2 receptors on NK cells
IL10 InnateDB 3586 397106 interleukin 10 interleukin 10 21849677 Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
IL1R2 InnateDB 7850 100628112 interleukin 1 receptor type 2 interleukin 1 receptor type 2 25461404 Structure of the activating IL-1 receptor signaling complex
IL1R1 InnateDB 3554 100626904 interleukin 1 receptor type 1 interleukin 1 receptor type 1 22426547 ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface
IL1RL2 InnateDB 8808 106509756 interleukin 1 receptor like 2 interleukin 1 receptor like 2 21860022 Soluble ST2 protein inhibits LPS stimulation on monocyte-derived dendritic cells
IL1RL1 InnateDB 9173 100127134 interleukin 1 receptor like 1 interleukin 1 receptor like 1 22922442 Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8
IRAK4 InnateDB 51135 100127166 interleukin 1 receptor associated kinase 4 interleukin 1 receptor associated kinase 4 20595480 IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M
IRAK3 InnateDB 11213 100514645 interleukin 1 receptor associated kinase 3 interleukin 1 receptor associated kinase 3 22154382 The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation
IRAK2 InnateDB 3656 106505672 interleukin 1 receptor associated kinase 2 interleukin 1 receptor associated kinase 2 21291324 IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50
IRAK1BP1 InnateDB 134728 100156851 interleukin 1 receptor associated kinase 1 binding protein 1 interleukin 1 receptor associated kinase 1 binding protein 1 20534545 Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression
IRAK1 InnateDB 3654 396606 interleukin 1 receptor associated kinase 1 interleukin 1 receptor associated kinase 1 21220427 Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages
IL1RAPL1 InnateDB 11141 100621199 interleukin 1 receptor accessory protein like 1 interleukin 1 receptor accessory protein like 1 25654981 Structure of the activating IL-1 receptor signaling complex
IL1RAP InnateDB 3556 100628318 interleukin 1 receptor accessory protein interleukin 1 receptor accessory protein 22426547 ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface
IL1B InnateDB 3553 397122 interleukin 1 beta interleukin 1 beta 21170027 Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway
IL1A InnateDB 3552 397094 interleukin 1 alpha interleukin 1 alpha 24022484 Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member
IFITM1 InnateDB 8519 100127358 interferon induced transmembrane protein 1 interferon-induced transmembrane protein 1 20064371 Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages
IFIT1 InnateDB 3434 100153038 interferon induced protein with tetratricopeptide repeats 1 interferon-induced protein with tetratricopeptide repeats 1 21642987 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA
IFNA1 InnateDB 3439 397686 interferon alpha 1 interferon, alpha 1 15883164 The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
ISG20 InnateDB 3669 448855 interferon stimulated exonuclease gene 20 interferon stimulated exonuclease gene 20 15064795 Hepatitis C virus reveals a novel early control in acute immune response
IFRD1 InnateDB 3475 493185 interferon related developmental regulator 1 interferon related developmental regulator 1 26055519 A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses
IRF9 InnateDB 10379 780415 interferon regulatory factor 9 interferon regulatory factor 9 9242679 The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation
IRF8 InnateDB 3394 396645 interferon regulatory factor 8 interferon regulatory factor 8 22942423 Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
IRF7 InnateDB 3665 100037289 interferon regulatory factor 7 interferon regulatory factor 7 21820332 TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis
IRF6 InnateDB 3664 397521 interferon regulatory factor 6 interferon regulatory factor 6 12219090 Activation of interferon regulatory factor 5 by site specific phosphorylation
IRF5 InnateDB 3663 100515633 interferon regulatory factor 5 interferon regulatory factor 5 22412986 Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4)
IRF4 InnateDB 3662 100144625 interferon regulatory factor 4 interferon regulatory factor 4 12566414 Sindbis virus induced phosphorylation of IRF3 in human embryonic kidney cells is not dependent on mTOR
IRF3 InnateDB 3661 396656 interferon regulatory factor 3 interferon regulatory factor 3 21768204 IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription
IRF2BP1 InnateDB 26145 100512233 interferon regulatory factor 2 binding protein 1 interferon regulatory factor 2 binding protein 1 18671972 Regulation of IRF2 transcriptional activity by its sumoylation
IRF2 InnateDB 3660 100621620 interferon regulatory factor 2 interferon regulatory factor 2 18514056 Characterization of an interferon-stimulated response element (ISRE) in the Il23a promoter
IRF1 InnateDB 3659 396611 interferon regulatory factor 1 interferon regulatory factor 1 21097874 Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection
IFIH1 InnateDB 64135 100101927 interferon induced with helicase C domain 1 interferon induced with helicase C domain 1 21245317 Activation of IFN-β expression by a viral mRNA through RNase L and MDA5
IFITM3 InnateDB 10410 100518544 interferon induced transmembrane protein 3 interferon induced transmembrane protein 3 20064371 Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages
IFIT5 InnateDB 24138 100151816 interferon induced protein with tetratricopeptide repeats 5 interferon induced protein with tetratricopeptide repeats 5 26334375 IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)
IFIT3 InnateDB 3437 100154248 interferon induced protein with tetratricopeptide repeats 3 interferon induced protein with tetratricopeptide repeats 3 21813773 IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1
IFIT2 InnateDB 3433 100155467 interferon induced protein with tetratricopeptide repeats 2 interferon induced protein with tetratricopeptide repeats 2 22065572 Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection
IFNGR2 InnateDB 3460 100126864 interferon gamma receptor 2 interferon gamma receptor 2 9001223 Single-cell analysis reveals new subset markers of murine peritoneal macrophages and highlights macrophage dynamics upon Staphylococcus aureus peritonitis
IFNGR1 InnateDB 3459 100152238 interferon gamma receptor 1 interferon gamma receptor 1 27220602 TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens
IFNG InnateDB 3458 396991 interferon gamma interferon gamma 23754402 Interferon-ε protects the female reproductive tract from viral and bacterial infection
IFNE InnateDB 338376 100125969 interferon epsilon interferon epsilon 23449591 Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis
IFNB1 InnateDB 3456 445459 interferon beta 1 interferon beta 1 21408089 Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
IFI6 InnateDB 2537 110261124 interferon alpha inducible protein 6 interferon alpha inducible protein 6 15685448 G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell
IFNAR1 InnateDB 3454 396658 interferon alpha and beta receptor subunit 1 interferon alpha and beta receptor subunit 1 21408089 Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
ICAM1 InnateDB 3383 396750 intercellular adhesion molecule 1 intercellular adhesion molecule 1 25549946 The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
ITGB3 InnateDB 3690 397063 integrin subunit beta 3 integrin subunit beta 3 23150579 Regulation of innate immune response to Candida albicans infections by αMβ2-Pra1p interaction
ITGB2 InnateDB 3689 396943 integrin subunit beta 2 integrin subunit beta 2 21245270 Human integrin α(3)β(1) regulates TLR2 recognition of lipopeptides from endosomal compartments
ITGB1 InnateDB 3688 397019 integrin subunit beta 1 integrin subunit beta 1 20877569 CD11c controls herpes simplex virus 1 responses to limit virus replication during primary infection
ITGAV InnateDB 3685 397285 integrin subunit alpha V integrin subunit alpha V 23150579 Regulation of innate immune response to Candida albicans infections by αMβ2-Pra1p interaction
ITGAM InnateDB 3684 397459 integrin subunit alpha M integrin subunit alpha M 20639876 Human integrin α(3)β(1) regulates TLR2 recognition of lipopeptides from endosomal compartments
ITGA3 InnateDB 3675 100517053 integrin subunit alpha 3 integrin subunit alpha 3 20877569 CD11c controls herpes simplex virus 1 responses to limit virus replication during primary infection
IGF1R InnateDB 3480 397350 insulin like growth factor 1 receptor insulin like growth factor 1 receptor 10747872 Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells
IGF1 InnateDB 3479 397491 insulin like growth factor 1 insulin like growth factor 1 21262348 Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections
INSIG1 InnateDB 3638 403162 insulin induced gene 1 insulin induced gene 1 25526307 Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a LyPI3K module and promoted by SHIP1
INPP5D InnateDB 3635 100526019 inositol polyphosphate-5-phosphatase D inositol polyphosphate-5-phosphatase D 20385881 Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes
IP6K1 InnateDB 9807 100513565 inositol hexakisphosphate kinase 1 inositol hexakisphosphate kinase 1 21685907 The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING
ITPR3 InnateDB 3710 100155015 inositol 1,4,5-trisphosphate receptor type 3 inositol 1,4,5-trisphosphate receptor type 3 21239714 Activation of STAT6 by STING is critical for antiviral innate immunity
ITPR1 InnateDB 3708 397454 inositol 1,4,5-trisphosphate receptor type 1 inositol 1,4,5-trisphosphate receptor type 1 21239714 Activation of STAT6 by STING is critical for antiviral innate immunity
IMPDH2 InnateDB 3615 100525485 inosine monophosphate dehydrogenase 2 inosine monophosphate dehydrogenase 2 21460227 MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90
IKBKE InnateDB 9641 100519508 inhibitor of nuclear factor kappa B kinase subunit epsilon inhibitor of nuclear factor kappa B kinase subunit epsilon 21138416 Novel cross-talk within the IKK family controls innate immunity
IKBKB InnateDB 3551 100101471 inhibitor of nuclear factor kappa B kinase subunit beta inhibitor of nuclear factor kappa B kinase subunit beta 21138416 Novel cross-talk within the IKK family controls innate immunity
IKBKG InnateDB 8517 100127355 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma inhibitor of nuclear factor kappa B kinase regulatory subunit gamma 10968790 Novel cross-talk within the IKK family controls innate immunity
ING4 InnateDB 51147 102161011 inhibitor of growth family member 4 inhibitor of growth family member 4 20534538 IMPDHII protein inhibits Toll-like receptor 2-mediated activation of NF-kappaB
ID2 InnateDB 3398 654298 inhibitor of DNA binding 2 inhibitor of DNA binding 2 25902484 Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota
IDO1 InnateDB 3620 100519877 indoleamine 2,3-dioxygenase 1 indoleamine 2,3-dioxygenase 1 22355111 Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
HIF1AN InnateDB 55662 100155854 hypoxia inducible factor 1 subunit alpha inhibitor hypoxia inducible factor 1 subunit alpha inhibitor 24145445 Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways
HIF1A InnateDB 3091 396696 hypoxia inducible factor 1 subunit alpha hypoxia inducible factor 1 subunit alpha 21685248 Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression
HSPBP1 InnateDB 23640 100518376 HSPA (Hsp70) binding protein 1 HSPA (Hsp70) binding protein 1 21247889 The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex
HRAS InnateDB 3265 110259208 HRas proto-oncogene, GTPase HRas proto-oncogene, GTPase 12867418 Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages
HOXA9 InnateDB 3205 100519066 homeobox A9 homeobox A9 18981407 Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions
HDAC2 InnateDB 3066 100156170 histone deacetylase 2 histone deacetylase 2 26287468 A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens
HDAC11 InnateDB 79885 100515581 histone deacetylase 11 histone deacetylase 11 23980205 Type I IFN inhibits innate IL-10 production in macrophages through histone deacetylase 11 by downregulating microRNA-145
HDAC1 InnateDB 3065 100622482 histone deacetylase 1 histone deacetylase 1 24550390 Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages
HRG InnateDB 3273 100152095 histidine rich glycoprotein histidine rich glycoprotein 21757718 Histidine-rich glycoprotein binds fibrin(ogen) with high affinity and competes with thrombin for binding to the gamma'-chain
HRH4 InnateDB 59340 397224 histamine receptor H4 histamine receptor H4 21469095 Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation
HMGN2 InnateDB 3151 100524500 high mobility group nucleosomal binding domain 2 high mobility group nucleosomal binding domain 2 21518253 The chromosomal protein HMGN2 mediates lipopolysaccharide-induced expression of β-defensins in A549 cells
HMGB3 InnateDB 3149 100517745 high mobility group box 3 high mobility group box 3 19890330 HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
HMGB2 InnateDB 3148 397130 high mobility group box 2 high mobility group box 2 19890330 HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
HMGB1 InnateDB 3146 445521 high mobility group box 1 high mobility group box 1 21372296 High-mobility group box-1 mediates toll-like receptor 4-dependent angiogenesis
HNRNPL InnateDB 3191 102163392 heterogeneous nuclear ribonucleoprotein L heterogeneous nuclear ribonucleoprotein L 24371310 The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL
HAMP InnateDB 57817 397207 hepcidin antimicrobial peptide hepcidin antimicrobial peptide 20530874 Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
HAVCR2 InnateDB 84868 100522045 hepatitis A virus cellular receptor 2 hepatitis A virus cellular receptor 2 21637332 Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection
HS2ST1 InnateDB 9653 100156232 heparan sulfate 2-O-sulfotransferase 1 heparan sulfate 2-O-sulfotransferase 1 26150541 Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity
HMOX1 InnateDB 3162 445512 heme oxygenase 1 heme oxygenase 1 21307647 Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway
HACE1 InnateDB 57531 100156102 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 27213432 HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex
HERC5 InnateDB 51191 100518083 HECT and RLD domain containing E3 ubiquitin protein ligase 5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 20308324 Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification
HSF1 InnateDB 3297 100511321 heat shock transcription factor 1 heat shock transcription factor 1 22042134 Heat shock factor 1 protects against lung mycoplasma pneumoniae infection in mice
HSPD1 InnateDB 3329 492279 heat shock protein family D (Hsp60) member 1 heat shock protein family D (Hsp60) member 1 21145789 The HSP60 immune system network
HSPA14 InnateDB 51182 100510924 heat shock protein family A (Hsp70) member 14 heat shock protein family A (Hsp70) member 14 21730052 Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response
HSP90B1 InnateDB 7184 397191 heat shock protein 90 beta family member 1 heat shock protein 90 beta family member 1 22109526 gp96 expression in neutrophils is critical for the onset of Escherichia coli K1 (RS218) meningitis
HSP90AA1 InnateDB 3320 397028 heat shock protein 90 alpha family class A member 1 heat shock protein 90 alpha family class A member 1 17420470 E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}
HP InnateDB 3240 397061 haptoglobin haptoglobin 22156194 Haptoglobin activates innate immunity to enhance acute transplant rejection in mice
GBP2 InnateDB 2634 100153137 guanylate binding protein 2 guanylate binding protein 2, interferon-inducible 21757726 Spleen tyrosine kinase mediates BEAS-2B cell migration and proliferation and human rhinovirus-induced expression of vascular endothelial growth factor and interleukin-8
GBP1 InnateDB 2633 100151938 guanylate binding protein 1 guanylate binding protein 1, interferon-inducible 21551061 Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection
GAS6 InnateDB 2621 100519331 growth arrest specific 6 growth arrest specific 6 22043818 Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages
GAB1 InnateDB 2549 100511026 GRB2 associated binding protein 1 GRB2 associated binding protein 1 20435932 Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages
GZMM InnateDB 3004 100233186 granzyme M granzyme M 21979465 FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade
GRN InnateDB 2896 733645 granulin precursor granulin precursor 21497117 Granulin is a soluble cofactor for toll-like receptor 9 signaling
GOPC InnateDB 57120 100520524 golgi associated PDZ and coiled-coil motif containing golgi associated PDZ and coiled-coil motif containing 16878151 Human papillomavirus type 16 E6 protein interacts with cystic fibrosis transmembrane regulator-associated ligand and promotes E6-associated protein-mediated ubiquitination and proteasomal degradation
GP2 InnateDB 2813 100303610 glycoprotein 2 glycoprotein 2 21468225 Glycoprotein 2 (GP2): grabbing the FimH bacteria into M cells for mucosal immunity
GSK3B InnateDB 2932 100126852 glycogen synthase kinase 3 beta glycogen synthase kinase 3 beta 21515258 GSK-3β-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock
GSK3A InnateDB 2931 100515208 glycogen synthase kinase 3 alpha glycogen synthase kinase 3 alpha 26100021 Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway
GLRX InnateDB 2745 397463 glutaredoxin glutaredoxin 23159440 Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils
GLI1 InnateDB 2735 100520490 GLI family zinc finger 1 GLI family zinc finger 1 20547752 Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65
GATA6 InnateDB 2627 397600 GATA binding protein 6 GATA binding protein 6 21971825 Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter
GATA4 InnateDB 2626 397555 GATA binding protein 4 GATA binding protein 4 21971825 Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter
GATA3 InnateDB 2625 733631 GATA binding protein 3 GATA binding protein 3 23733962 Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells
GJA1 InnateDB 2697 100518636 gap junction protein alpha 1 gap junction protein alpha 1 19528242 TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury
LGALS9 InnateDB 3965 396972 galectin 9 galectin 9 21562126 Innate immune lectins kill bacteria expressing blood group antigen
LGALS8 InnateDB 3964 100156193 galectin 8 galectin 8 20154696 Endogenous galectin-3 controls experimental malaria in a species-specific manner
LGALS4 InnateDB 3960 397041 galectin 4 galectin 4 20154696 Endogenous galectin-3 controls experimental malaria in a species-specific manner
LGALS3 InnateDB 3958 100038033 galectin 3 galectin 3 22486577 Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation
LGALS2 InnateDB 3957 100217393 galectin 2 galectin 2 15356130 Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway
LGALS1 InnateDB 3956 414915 galectin 1 galectin 1 19561030 Leptin up-regulates TLR2 in human monocytes
GABARAP InnateDB 11337 100462752 GABA type A receptor-associated protein GABA type A receptor-associated protein 23427251 Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses
G3BP1 InnateDB 10146 100513766 G3BP stress granule assembly factor 1 G3BP stress granule assembly factor 1 25520508 The stress granule protein G3BP1 recruits protein kinase R to promote multiple innate immune antiviral responses
GRK5 InnateDB 2869 100152937 G protein-coupled receptor kinase 5 G protein-coupled receptor kinase 5 20945396 G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice
GPR33 InnateDB 2856 100157823 G protein-coupled receptor 33 G protein-coupled receptor 33 20399748 Involvement of the chemokine-like receptor GPR33 in innate immunity
GNB2 InnateDB 2783 100516546 G protein subunit beta 2 G protein subunit beta 2 20525682 Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils
GNAI3 InnateDB 2773 100144421 G protein subunit alpha i3 G protein subunit alpha i3 21209316 A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals
GNAI2 InnateDB 2771 397523 G protein subunit alpha i2 G protein subunit alpha i2 21255617 Heterotrimeric Gα(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis
GPSM1 InnateDB 26086 110258076 G protein signaling modulator 1 G protein signaling modulator 1 21209316 A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals
FZD1 InnateDB 8321 110262227 frizzled class receptor 1 frizzled class receptor 1 20667980 Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages
FFAR2 InnateDB 2867 100126285 free fatty acid receptor 2 free fatty acid receptor 2 19865172 Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
FREM1 InnateDB 158326 100514332 FRAS1 related extracellular matrix 1 FRAS1 related extracellular matrix 1 22262840 Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR
FOXO3 InnateDB 2309 733621 forkhead box O3 forkhead box O3 22531926 FOXO3 as a new IKK-ε-controlled check-point of regulation of IFN-β expression
FOXA2 InnateDB 3170 100513828 forkhead box A2 forkhead box A2 20483781 Foxa2 programs Th2 cell-mediated innate immunity in the developing lung
FSTL1 InnateDB 11167 110256417 follistatin like 1 follistatin like 1 22265692 Follistatin-related proteifollistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4
FLT4 InnateDB 2324 100518179 fms related receptor tyrosine kinase 4 fms related receptor tyrosine kinase 4 24656836 RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism
FXR1 InnateDB 8087 100525539 FMR1 autosomal homolog 1 FMR1 autosomal homolog 1 19864602 The bile acid receptor FXR is a modulator of intestinal innate immunity
FLI1 InnateDB 2313 100515914 Fli-1 proto-oncogene, ETS transcription factor Fli-1 proto-oncogene, ETS transcription factor 20879862 Downregulation of Friend leukemia virus integration 1 as a feedback mechanism that restrains lipopolysaccharide induction of matrix metalloproteases and interleukin-10 in human macrophages
FCN1 InnateDB 2219 397316 ficolin 1 ficolin (collagen/fibrinogen domain containing) 1 20375620 The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking
FCN2 InnateDB 2220 396881 ficolin 2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 20375620 The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking
FGF7 InnateDB 2252 397281 fibroblast growth factor 7 fibroblast growth factor 7 21343299 Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages
FER InnateDB 2241 100513914 FER tyrosine kinase FER tyrosine kinase 23355730 Fer kinase limits neutrophil chemotaxis toward end target chemoattractants
FCRL5 InnateDB 83416 100155684 Fc receptor like 5 Fc receptor like 5 20519648 Cutting edge: FcR-like 5 on innate B cells is targeted by a poxvirus MHC class I-like immunoevasin
FCGR1A InnateDB 2209 613130 Fc gamma receptor Ia Fc fragment of IgG, high affinity Ia, receptor (CD64) 21044955 Interaction of two phagocytic host defense systems: Fcγ receptors and complement receptor 3
FBXW5 InnateDB 54461 100514029 F-box and WD repeat domain containing 5 F-box and WD repeat domain containing 5 19232515 An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway
FSCN1 InnateDB 6624 100286741 fascin actin-bundling protein 1 fascin actin-bundling protein 1 24244012 Fascin confers resistance to Listeria infection in dendritic cells
FADD InnateDB 8772 595129 Fas associated via death domain Fas associated via death domain 21183682 Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production
FANCC InnateDB 2176 102158362 FA complementation group C FA complementation group C 22106009 Impaired function of Fanconi anemia type C-deficient macrophages
F2RL1 InnateDB 2150 100519703 F2R like trypsin receptor 1 F2R like trypsin receptor 1 18622013 Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity
F2RL3 InnateDB 9002 100514949 F2R like thrombin or trypsin receptor 3 F2R like thrombin or trypsin receptor 3 11907122 Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells
EIF4EBP2 InnateDB 1979 100523927 eukaryotic translation initiation factor 4E binding protein 2 eukaryotic translation initiation factor 4E binding protein 2 25531441 Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responses
EIF4EBP1 InnateDB 1978 100627508 eukaryotic translation initiation factor 4E binding protein 1 eukaryotic translation initiation factor 4E binding protein 1 25531441 Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responses
EIF4E InnateDB 1977 100038030 eukaryotic translation initiation factor 4E eukaryotic translation initiation factor 4E 22544393 Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E
EIF2AK2 InnateDB 5610 397588 eukaryotic translation initiation factor 2 alpha kinase 2 eukaryotic translation initiation factor 2 alpha kinase 2 22912779 Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity
EHMT2 InnateDB 10919 100124382 euchromatic histone lysine methyltransferase 2 euchromatic histone lysine methyltransferase 2 22412156 Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response
ETS1 InnateDB 2113 100302363 ETS proto-oncogene 1, transcription factor ETS proto-oncogene 1, transcription factor 20930145 Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators
EPOR InnateDB 2057 397554 erythropoietin receptor erythropoietin receptor 8068943 Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo
EPS8 InnateDB 2059 100525921 epidermal growth factor receptor pathway substrate 8 epidermal growth factor receptor pathway substrate 8 22493489 Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages
EGFR InnateDB 1956 397070 epidermal growth factor receptor epidermal growth factor receptor 26243875 IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions
EZH2 InnateDB 2146 100625497 enhancer of zeste 2 polycomb repressive complex 2 subunit enhancer of zeste 2 polycomb repressive complex 2 subunit 26668377 Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity
EDN1 InnateDB 1906 396915 endothelin 1 endothelin 1 21730058 A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block
ERN1 InnateDB 2081 100510978 endoplasmic reticulum to nucleus signaling 1 endoplasmic reticulum to nucleus signaling 1 22883233 The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy
ERAP1 InnateDB 51752 100523953 endoplasmic reticulum aminopeptidase 1 endoplasmic reticulum aminopeptidase 1 18445477 An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release
ELP2 InnateDB 55250 100621519 elongator acetyltransferase complex subunit 2 elongator acetyltransferase complex subunit 2 10954736 A Stat3-interacting protein (StIP1) regulates cytokine signal transduction
EFTUD2 InnateDB 9343 100522208 elongation factor Tu GTP binding domain containing 2 elongation factor Tu GTP binding domain containing 2 25878102 EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway
ELMOD2 InnateDB 255520 100738980 ELMO domain containing 2 ELMO domain containing 2 19966137 ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses
ELAVL1 InnateDB 1994 100337681 ELAV like RNA binding protein 1 ELAV like RNA binding protein 1 14981256 Identification of a target RNA motif for RNA-binding protein HuR
ELANE InnateDB 1991 100522182 elastase, neutrophil expressed elastase, neutrophil expressed 18772136 Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway
EGLN2 InnateDB 112398 100523673 egl-9 family hypoxia inducible factor 2 egl-9 family hypoxia inducible factor 2 24145445 Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways
EDIL3 InnateDB 10085 100516065 EGF like repeats and discoidin domains 3 EGF like repeats and discoidin domains 3 22447028 The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
ECSIT InnateDB 51295 100519412 ECSIT signaling integrator ECSIT signaling integrator 10465784 ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
EGR1 InnateDB 1958 100520726 early growth response 1 early growth response 1 15545275 Early growth response-1 regulates lipopolysaccharide-induced suppressor of cytokine signaling-1 transcription
ELF4 InnateDB 2000 100523880 E74 like ETS transcription factor 4 E74 like ETS transcription factor 4 24185615 ELF4 is critical for induction of type I interferon and the host antiviral response
ELF1 InnateDB 1997 100512366 E74 like ETS transcription factor 1 E74 like ETS transcription factor 1 21867680 Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-1
E2F1 InnateDB 1869 100153846 E2F transcription factor 1 E2F transcription factor 1 21131441 Novel regulators of the systemic response to lipopolysaccharide
DNM1L InnateDB 10059 100624497 dynamin 1 like dynamin 1 like 24733894 Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors
DUSP16 InnateDB 80824 100620494 dual specificity phosphatase 16 dual specificity phosphatase 16 24311790 Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production
DUSP10 InnateDB 11221 100517416 dual specificity phosphatase 10 dual specificity phosphatase 10 22307906 Map kinase phosphatase 5 protects against sepsis-induced acute lung injury
DUSP1 InnateDB 1843 100522469 dual specificity phosphatase 1 dual specificity phosphatase 1 21959016 Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
DUOX2 InnateDB 50506 397060 dual oxidase 2 dual oxidase 2 21714724 Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa
DUOX1 InnateDB 53905 397177 dual oxidase 1 dual oxidase 1 18511861 RGS2 is a negative regulator of STAT3-mediated Nox1 expression
DR1 InnateDB 1810 100152776 down-regulator of transcription 1 down-regulator of transcription 1 25589657 A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication
DRD2 InnateDB 1813 100624857 dopamine receptor D2 dopamine receptor D2 23242137 Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin
DOK3 InnateDB 79930 110259391 docking protein 3 docking protein 3 22761938 DOK3 negatively regulates LPS responses and endotoxin tolerance
DDIT3 InnateDB 1649 100240743 DNA damage inducible transcript 3 DNA damage inducible transcript 3 20876114 Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression
DICER1 InnateDB 23405 100505387 dicer 1, ribonuclease III dicer 1, ribonuclease III 22252463 Reduced DICER1 elicits an interferon response in endometrial cancer cells
DAGLB InnateDB 221955 100627176 diacylglycerol lipase beta diacylglycerol lipase beta 23103940 DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses
DHX9 InnateDB 1660 100514066 DExH-box helicase 9 DExH-box helicase 9 20696886 Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
DHX58 InnateDB 79132 100524520 DExH-box helicase 58 DExH-box helicase 58 24434553 RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation
DDX21 InnateDB 9188 100153111 DExD-box helicase 21 DExD-box helicase 21 21703541 DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells
DDX58 InnateDB 23586 396723 DExD/H-box helicase 58 DExD/H-box helicase 58 19936053 Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila
DLK1 InnateDB 8788 497066 delta like non-canonical Notch ligand 1 delta like non-canonical Notch ligand 1 22072963 The critical role of Notch ligand Delta-like 1 in the pathogenesis of influenza A virus (H1N1) infection
DMBT1 InnateDB 1755 751862 deleted in malignant brain tumors 1 deleted in malignant brain tumors 1 20418254 Review: Gp-340/DMBT1 in mucosal innate immunity
DEFB1 InnateDB 1672 404699 defensin beta 1 defensin beta 1 21551252 Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity
DCN InnateDB 1634 396957 decorin decorin 22087031 Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21
DAXX InnateDB 1616 100524813 death domain associated protein death domain associated protein 24550390 Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages
DHX36 InnateDB 170506 100626674 DEAH-box helicase 36 DEAH-box helicase 36 21703541 DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells
DHX33 InnateDB 56919 110256102 DEAH-box helicase 33 DEAH-box helicase 33 25816776 RNase L activates the NLRP3 inflammasome during viral infections
DHX15 InnateDB 1665 100517041 DEAH-box helicase 15 DEAH-box helicase 15 26494172 Nlrp6 regulates intestinal antiviral innate immunity
DDX41 InnateDB 51428 110259388 DEAD-box helicase 41 DEAD-box helicase 41 21892174 The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
DDX3X InnateDB 1654 100515940 DEAD-box helicase 3 X-linked DEAD-box helicase 3 X-linked 18583960 The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
DDX1 InnateDB 1653 100627404 DEAD-box helicase 1 DEAD-box helicase 1 21703541 DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells
DAB2IP InnateDB 153090 100628179 DAB2 interacting protein DAB2 interacting protein 19948740 AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling
CTLA4 InnateDB 1493 397286 cytotoxic T-lymphocyte associated protein 4 cytotoxic T-lymphocyte associated protein 4 18824539 Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis
CISH InnateDB 1154 100518866 cytokine inducible SH2 containing protein cytokine inducible SH2 containing protein 19592657 MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα
CYTIP InnateDB 9595 100627882 cytohesin 1 interacting protein cytohesin 1 interacting protein 17577583 α-Synuclein Alters Toll-Like Receptor Expression
CYBA InnateDB 1535 397507 cytochrome b-245 alpha chain cytochrome b-245 alpha chain 20142487 Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis
CYLD InnateDB 1540 100624570 CYLD lysine 63 deubiquitinase CYLD lysine 63 deubiquitinase 21498625 Bacterial LPS up-regulated TLR3 expression is critical for antiviral response in human monocytes: evidence for negative regulation by CYLD
CCNT1 InnateDB 904 100737376 cyclin T1 cyclin T1 18728388 Expanding role of cyclin dependent kinases in cytokine inducible gene expression
CDKN2A InnateDB 1029 396553 cyclin dependent kinase inhibitor 2A cyclin dependent kinase inhibitor 2A 22095712 The tumor suppressor ARF regulates innate immune responses in mice
CDKN1A InnateDB 1026 100152215 cyclin dependent kinase inhibitor 1A cyclin dependent kinase inhibitor 1A 26259914 Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
CDK9 InnateDB 1025 100307051 cyclin dependent kinase 9 cyclin dependent kinase 9 18728388 Expanding role of cyclin dependent kinases in cytokine inducible gene expression
CCNA2 InnateDB 890 100415929 cyclin A2 cyclin A2 25005359 Matrix protein CCN1 induced by bacterial DNA and CpG ODN limits lung inflammation and contributes to innate immune homeostasis
CXCR6 InnateDB 10663 414376 C-X-C motif chemokine receptor 6 C-X-C motif chemokine receptor 6 25456160 The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells
CXCR4 InnateDB 7852 396659 C-X-C motif chemokine receptor 4 C-X-C motif chemokine receptor 4 26026270 The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50
CXCR3 InnateDB 2833 100524123 C-X-C motif chemokine receptor 3 C-X-C motif chemokine receptor 3 21518789 Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis
CXCR2 InnateDB 3579 100124654 C-X-C motif chemokine receptor 2 C-X-C motif chemokine receptor 2 24651866 IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells
CXCL9 InnateDB 4283 100135681 C-X-C motif chemokine ligand 9 C-X-C motif chemokine ligand 9 21124994 Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection
CXCL16 InnateDB 58191 396735 C-X-C motif chemokine ligand 16 C-X-C motif chemokine ligand 16 20874518 CXCL16 contributes to neutrophil recruitment to cerebrospinal fluid in pneumococcal meningitis
CXCL14 InnateDB 9547 494467 C-X-C motif chemokine ligand 14 C-X-C motif chemokine ligand 14 25964486 CXCL14 displays antimicrobial activity against respiratory tract bacteria and contributes to clearance of Streptococcus pneumoniae pulmonary infection
CXCL13 InnateDB 10563 100524265 C-X-C motif chemokine ligand 13 C-X-C motif chemokine ligand 13 27220602 TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens
CXCL12 InnateDB 6387 494460 C-X-C motif chemokine ligand 12 C-X-C motif chemokine ligand 12 24000293 Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells
CXCL11 InnateDB 6373 100169744 C-X-C motif chemokine ligand 11 C-X-C motif chemokine ligand 11 21124994 Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection
CXCL10 InnateDB 3627 494019 C-X-C motif chemokine ligand 10 C-X-C motif chemokine ligand 10 21124994 Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection
CLEC4E InnateDB 26253 110260748 C-type lectin domain family 4 member E C-type lectin domain family 4 member E 21267996 C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide
CLEC1B InnateDB 51266 100623580 C-type lectin domain family 1 member B C-type lectin domain family 1 member B 21728173 CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses
CLEC9A InnateDB 283420 100623379 C-type lectin domain containing 9A C-type lectin domain containing 9A 22483800 F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells
CLEC7A InnateDB 64581 100038025 C-type lectin domain containing 7A C-type lectin domain containing 7A 21267996 C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide
CSK InnateDB 1445 100154110 C-terminal Src kinase C-terminal Src kinase 15749833 Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex
CRYAB InnateDB 1410 100519789 crystallin alpha B crystallin alpha B 23242137 Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin
CRKL InnateDB 1399 100525363 CRK like proto-oncogene, adaptor protein CRK like proto-oncogene, adaptor protein 9872990 Activation of a CrkL-stat5 signaling complex by type I interferons
CRP InnateDB 1401 100620468 C-reactive protein C-reactive protein 21415385 C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotype
CORO2A InnateDB 7464 100511910 coronin 2A coronin 2A 21331046 Coronin 2A mediates actin-dependent de-repression of inflammatory response genes
COPS8 InnateDB 10920 100515865 COP9 signalosome subunit 8 COP9 signalosome subunit 8 20074051 Control of NF-kappaB activation by the COP9 signalosome
COPS5 InnateDB 10987 100125955 COP9 signalosome subunit 5 COP9 signalosome subunit 5 21403132 Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages
CHUK InnateDB 1147 100135662 component of inhibitor of nuclear factor kappa B kinase complex component of inhibitor of nuclear factor kappa B kinase complex 21765415 The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling
CFP InnateDB 5199 100522293 complement factor properdin complement factor properdin 25725105 Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk
CFH InnateDB 3075 397525 complement factor H complement factor H 21285368 Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement
CFB InnateDB 629 100124383 complement factor B complement factor B 17921140 Profiling the enzymatic properties and inhibition of human complement factor B
C4BPB InnateDB 725 100520583 complement component 4 binding protein beta complement component 4 binding protein beta 21283780 Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
C4BPA InnateDB 722 100520761 complement component 4 binding protein alpha complement component 4 binding protein alpha 21283780 Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
C9 InnateDB 735 100037951 complement C9 complement C9 16189651 Emission of membrane vesicles: roles in complement resistance, immunity and cancer
C8G InnateDB 733 100037955 complement C8 gamma chain complement C8 gamma chain 11058761 Human complement protein C8 gamma
C8B InnateDB 732 100037954 complement C8 beta chain complement C8 beta chain 12220191 Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain
C8A InnateDB 731 100037953 complement C8 alpha chain complement C8 alpha chain 12220191 Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain
C7 InnateDB 730 397526 complement C7 complement C7 11058761 Human complement protein C8 gamma
C6 InnateDB 729 100037952 complement C6 complement C6 11058761 Human complement protein C8 gamma
C5AR1 InnateDB 728 100048955 complement C5a receptor 1 complement C5a receptor 1 20159852 Microbial hijacking of complement-toll-like receptor crosstalk
C5 InnateDB 727 414437 complement C5 complement C5 18039528 The role of the complement anaphylatoxins in the recruitment of eosinophils
C4A InnateDB 720 445467 complement C4A (Rodgers blood group) complement C4A (Rodgers blood group) 2650988 Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways
C3AR1 InnateDB 719 100625728 complement C3a receptor 1 complement C3a receptor 1 24273177 The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response
C3 InnateDB 718 397072 complement C3 complement C3 24273177 The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response
C2 InnateDB 717 448981 complement C2 complement C2 12791093 On the site of C4 deposition upon complement activation via the mannan-binding lectin pathway or the classical pathway
C1S InnateDB 716 397274 complement C1s complement C1s 16177097 Functional role of the linker between the complement control protein modules of complement protease C1s
C1R InnateDB 715 445464 complement C1r complement C1r 11445589 Assembly and enzymatic properties of the catalytic domain of human complement protease C1r
C1QC InnateDB 714 445460 complement C1q C chain complement C1q C chain 21450789 Complement and non-complement activating functions of C1q: a prototypical innate immune molecule
C1QBP InnateDB 708 110256103 complement C1q binding protein complement C1q binding protein 12574814 Activation-dependent surface expression of gC1qR/p33 on human blood platelets
C1QB InnateDB 713 100518846 complement C1q B chain complement C1q B chain 21450789 Complement and non-complement activating functions of C1q: a prototypical innate immune molecule
C1QA InnateDB 712 445461 complement C1q A chain complement C1q A chain 21450789 Complement and non-complement activating functions of C1q: a prototypical innate immune molecule
CSF2RB InnateDB 1439 100153254 colony stimulating factor 2 receptor subunit beta colony stimulating factor 2 receptor subunit beta 15988755 Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells
CSF2 InnateDB 1437 397208 colony stimulating factor 2 colony stimulating factor 2 23453633 Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member
CSF1R InnateDB 1436 100517086 colony stimulating factor 1 receptor colony stimulating factor 1 receptor 25757564 Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2
COLEC12 InnateDB 81035 102166764 collectin subfamily member 12 collectin subfamily member 12 26290605 Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway
CCDC88A InnateDB 55704 100514454 coiled-coil domain containing 88A coiled-coil domain containing 88A 21209316 A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals
COCH InnateDB 1690 100624179 cochlin cochlin 23684986 Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity
F11 InnateDB 2160 110257404 coagulation factor XI coagulation factor XI 21807745 Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes
F2RL2 InnateDB 2151 100519355 coagulation factor II thrombin receptor like 2 coagulation factor II thrombin receptor like 2 18264801 The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 release
F2R InnateDB 2149 100521609 coagulation factor II thrombin receptor coagulation factor II thrombin receptor 17977790 Protease-activated receptors: novel PARtners in innate immunity
CLTC InnateDB 1213 100271929 clathrin heavy chain clathrin heavy chain 21364927 Endocytosis-independent function of clathrin heavy chain in the control of basal NF-κB activation
CHGA InnateDB 1113 397540 chromogranin A chromogranin A 21214543 Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines
CHAT InnateDB 1103 396896 choline O-acetyltransferase choline O-acetyltransferase 23297238 Lymphocyte-derived ACh regulates local innate but not adaptive immunity
CXCL2 InnateDB 2920 414904 C-X-C motif chemokine ligand 2 chemokine (C-X-C motif) ligand 2 21757770 Kidney dendritic cells induce innate immunity against bacterial pyelonephritis
CCL2 InnateDB 6347 397422 C-C motif chemokine ligand 2 chemokine (C-C motif) ligand 2 21458307 Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands
CFTR InnateDB 1080 403154 CF transmembrane conductance regulator CF transmembrane conductance regulator 21712022 Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice
CDC42 InnateDB 998 780428 cell division cycle 42 cell division cycle 42 23690402 Cdc42 promotes host defenses against fatal infection
CAPRIN1 InnateDB 4076 100512646 cell cycle associated protein 1 cell cycle associated protein 1 25784705 A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus
CEACAM1 InnateDB 634 100512285 CEA cell adhesion molecule 1 CEA cell adhesion molecule 1 18836450 CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells
CD8A InnateDB 925 396627 CD8a molecule CD8a molecule 21867928 CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites
CD86 InnateDB 942 397441 CD86 molecule CD86 molecule 25549946 The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
CD81 InnateDB 975 780427 CD81 molecule CD81 molecule 25972472 Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
CD63 InnateDB 967 100155929 CD63 molecule CD63 molecule 18930046 Trafficking and function of the tetraspanin CD63
CD53 InnateDB 963 100152398 CD53 molecule CD53 molecule 20407468 A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels
CD5L InnateDB 922 100154019 CD5 molecule like CD5 molecule like 21730133 Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue
CD48 InnateDB 962 100511130 CD48 molecule CD48 molecule 26564814 TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB
CD47 InnateDB 961 397042 CD47 molecule CD47 molecule 26010544 CD47 Promotes Protective Innate and Adaptive Immunity in a Mouse Model of Disseminated Candidiasis
CD46 InnateDB 4179 396922 CD46 molecule CD46 molecule, complement regulatory protein 10233938 Human CD46 enhances nitric oxide production in mouse macrophages in response to measles virus infection in the presence of gamma interferon: dependence on the CD46 cytoplasmic domains
CD40 InnateDB 958 397395 CD40 molecule CD40 molecule 25549946 The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation
CD37 InnateDB 951 100624694 CD37 molecule CD37 molecule 17182550 Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production
CD36 InnateDB 948 733702 CD36 molecule CD36 molecule 24257313 The class A scavenger receptor SR-A/CD204 and the class B scavenger receptor CD36 regulate immune functions of macrophages differently
CD300A InnateDB 11314 102160266 CD300a molecule CD300a molecule 22043923 CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines
CD300LF InnateDB 146722 102158693 CD300 molecule like family member f CD300 molecule like family member f 22043923 CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines
CD274 InnateDB 29126 574058 CD274 molecule CD274 molecule 21097698 IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity
CD27 InnateDB 939 100520023 CD27 molecule CD27 molecule 9582383 CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase
CD22 InnateDB 933 102161349 CD22 molecule CD22 molecule 17562860 Sialoside-based pattern recognitions discriminating infections from tissue injuries
CD209 InnateDB 30835 100170134 CD209 molecule CD209 molecule 18998127 Innate signaling by the C-type lectin DC-SIGN dictates immune responses
CD200R1 InnateDB 131450 100155169 CD200 receptor 1 CD200 receptor 1 25654642 CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue
CD200 InnateDB 4345 100626182 CD200 molecule CD200 molecule 25654642 CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue
CD1D InnateDB 912 100124526 CD1d molecule CD1d molecule 24248359 Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation
CD180 InnateDB 4064 397644 CD180 molecule CD180 molecule 19154986 RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins
CD14 InnateDB 929 100037938 CD14 molecule CD14 molecule 21078886 CD14 is a coreceptor of Toll-like receptors 7 and 9
CNOT8 InnateDB 9337 100525087 CCR4-NOT transcription complex subunit 8 CCR4-NOT transcription complex subunit 8 23386060 hCAF1/CNOT7 regulates interferon signalling by targeting STAT1
CNOT4 InnateDB 4850 100622832 CCR4-NOT transcription complex subunit 4 CCR4-NOT transcription complex subunit 4 22159038 Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells
CTCF InnateDB 10664 100623274 CCCTC-binding factor CCCTC-binding factor 15670593 Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter
CEBPE InnateDB 1053 100157564 CCAAT enhancer binding protein epsilon CCAAT enhancer binding protein epsilon 21326902 The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ
CEBPD InnateDB 1052 100153946 CCAAT enhancer binding protein delta CCAAT enhancer binding protein delta 20829351 C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity
CEBPB InnateDB 1051 397360 CCAAT enhancer binding protein beta CCAAT enhancer binding protein beta 21326902 The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ
CEBPA InnateDB 1050 397307 CCAAT enhancer binding protein alpha CCAAT enhancer binding protein alpha 21326902 The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ
CCR7 InnateDB 1236 396663 C-C motif chemokine receptor 7 C-C motif chemokine receptor 7 20176793 CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection
CCR6 InnateDB 1235 100624245 C-C motif chemokine receptor 6 C-C motif chemokine receptor 6 21042003 Cysteine-cysteinyl chemokine receptor 6 mediates invariant natural killer T cell airway recruitment and innate stage resistance during mycobacterial infection
CCR4 InnateDB 1233 100623410 C-C motif chemokine receptor 4 C-C motif chemokine receptor 4 18624303 CC chemokine receptor 4 modulates Toll-like receptor 9-mediated innate immunity and signaling
CCR3 InnateDB 1232 414373 C-C motif chemokine receptor 3 C-C motif chemokine receptor 3 21660963 Pulmonary epithelial CCR3 promotes LPS-induced lung inflammation by mediating release of IL-8
CCL5 InnateDB 6352 396613 C-C motif chemokine ligand 5 C-C motif chemokine ligand 5 26305961 NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets
CCL17 InnateDB 6361 780408 C-C motif chemokine ligand 17 C-C motif chemokine ligand 17 22057112 CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis
CCL1 InnateDB 6346 100310829 C-C motif chemokine ligand 1 C-C motif chemokine ligand 1 18981157 Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression
CBL InnateDB 867 100518854 Cbl proto-oncogene Cbl proto-oncogene 21799517 The E3 ligase c-Cbl regulates dendritic cell activation
CAV1 InnateDB 857 404693 caveolin 1 caveolin 1 19949109 Caveolin-1 modifies the immunity to Pseudomonas aeruginosa
CTSS InnateDB 1520 100153090 cathepsin S cathepsin S 21145045 Cytokines regulate cysteine cathepsins during TLR responses
CTSK InnateDB 1513 397569 cathepsin K cathepsin K 18762176 Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair
CTSH InnateDB 1512 396969 cathepsin H cathepsin H 18762176 Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair
CTSD InnateDB 1509 494568 cathepsin D cathepsin D 18762176 Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair
CTSB InnateDB 1508 100037961 cathepsin B cathepsin B 21145045 Cytokines regulate cysteine cathepsins during TLR responses
CTNND1 InnateDB 1500 100519699 catenin delta 1 catenin delta 1 25773174 p120-catenin expressed in alveolar type II cells is essential for the regulation of lung innate immune response
CTNNB1 InnateDB 1499 397657 catenin beta 1 catenin beta 1 26100021 Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway
CTNNAL1 InnateDB 8727 100626033 catenin alpha like 1 catenin alpha like 1 17952117 Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis
CARD9 InnateDB 64170 110258075 caspase recruitment domain family member 9 caspase recruitment domain family member 9 20351059 The adaptor molecule CARD9 is essential for tuberculosis control
CARD6 InnateDB 84674 100627238 caspase recruitment domain family member 6 caspase recruitment domain family member 6 16418290 Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation
CASP8 InnateDB 841 595105 caspase 8 caspase 8 21419663 RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein
CASP7 InnateDB 840 100156777 caspase 7 caspase 7 22807671 Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response
CASP6 InnateDB 839 100517293 caspase 6 caspase 6 21098228 Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M
CASP2 InnateDB 835 100521118 caspase 2 caspase 2 26341399 Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage
CASP10 InnateDB 843 100154896 caspase 10 caspase 10 17822854 Cloning and characterization of a novel caspase-10 isoform that activates NF-kappa B activity
CASP1 InnateDB 834 397319 caspase 1 caspase 1, apoptosis-related cysteine peptidase 19362023 The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
CFLAR InnateDB 8837 414381 CASP8 and FADD like apoptosis regulator CASP8 and FADD like apoptosis regulator 21635783 FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling
CNPY3 InnateDB 10695 100126290 canopy FGF signaling regulator 3 canopy FGF signaling regulator 3 18780723 A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors
CREB1 InnateDB 1385 100736562 cAMP responsive element binding protein 1 cAMP responsive element binding protein 1 23405224 Increased abscess formation and defective chemokine regulation in CREB transgenic mice
CALM1 InnateDB 801 100154056 calmodulin 1 calmodulin 1 16893173 NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity
CAMKK2 InnateDB 10645 100157312 calcium/calmodulin dependent protein kinase kinase 2 calcium/calmodulin dependent protein kinase kinase 2 22334678 Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses
CAMK2A InnateDB 815 100626014 calcium/calmodulin dependent protein kinase II alpha calcium/calmodulin dependent protein kinase II alpha 18818394 CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages
CALCOCO2 InnateDB 10241 100523089 calcium binding and coiled-coil domain 2 calcium binding and coiled-coil domain 2 22901810 Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway
BTK InnateDB 695 100627308 Bruton tyrosine kinase Bruton tyrosine kinase 21441935 Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk
BDKRB2 InnateDB 624 110255240 bradykinin receptor B2 bradykinin receptor B2 18810490 The bradykinin B2 receptor in the early immune response against Listeria infection
BST2 InnateDB 684 100302088 bone marrow stromal cell antigen 2 bone marrow stromal cell antigen 2 22072710 HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions
BMX InnateDB 660 100516528 BMX non-receptor tyrosine kinase BMX non-receptor tyrosine kinase 18025155 Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity
BGN InnateDB 633 397396 biglycan biglycan 24257755 Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans
BID InnateDB 637 594852 BH3 interacting domain death agonist BH3 interacting domain death agonist 21552281 Non-apoptotic role of BID in inflammation and innate immunity
BECN1 InnateDB 8678 733576 beclin 1 beclin 1 18772134 MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
BCL3 InnateDB 602 100738193 BCL3 transcription coactivator BCL3 transcription coactivator 21228348 The IκB family member Bcl-3 coordinates the pulmonary defense against Klebsiella pneumoniae infection
BCL2A1 InnateDB 597 100156860 BCL2 related protein A1 BCL2 related protein A1 21167304 Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages
BCL2L1 InnateDB 598 397536 BCL2 like 1 BCL2 like 1 24412611 Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis
BNIP3L InnateDB 665 100152675 BCL2 interacting protein 3 like BCL2 interacting protein 3 like 26253785 BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory
BNIP3 InnateDB 664 100624868 BCL2 interacting protein 3 BCL2 interacting protein 3 26253785 BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory
BCL2 InnateDB 596 100049703 BCL2 apoptosis regulator BCL2 apoptosis regulator 21850221 Bcl-2 inhibits the innate immune response during early pathogenesis of murine congenital muscular dystrophy
BCL10 InnateDB 8915 100125346 BCL10 immune signaling adaptor BCL10 immune signaling adaptor 18806265 Multiple protein domains mediate interaction between Bcl10 and MALT1
BCAR1 InnateDB 9564 100621541 BCAR1 scaffold protein, Cas family member BCAR1 scaffold protein, Cas family member 17129785 Force sensing by mechanical extension of the Src family kinase substrate p130Cas
BAIAP2L1 InnateDB 55971 100521439 BAR/IMD domain containing adaptor protein 2 like 1 BAR/IMD domain containing adaptor protein 2 like 1 26348439 IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation
BCL11B InnateDB 64919 100154158 BAF chromatin remodeling complex subunit BCL11B BAF chromatin remodeling complex subunit BCL11B 25964371 The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
BIRC5 InnateDB 332 397266 baculoviral IAP repeat containing 5 baculoviral IAP repeat containing 5 20406824 Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells
BIRC3 InnateDB 330 100622590 baculoviral IAP repeat containing 3 baculoviral IAP repeat containing 3 21447281 Sensing cytoplasmic danger signals by the inflammasome
AXL InnateDB 558 100144875 AXL receptor tyrosine kinase AXL receptor tyrosine kinase 23954153 A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C)
ATG9A InnateDB 79065 100155182 autophagy related 9A autophagy related 9A 19926846 Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
ATG7 InnateDB 10533 100462749 autophagy related 7 autophagy related 7 25512546 Essential role for autophagy during invariant NKT cell development
ATG5 InnateDB 9474 100739102 autophagy related 5 autophagy related 5 17921696 The non-canonical role of Atg family members as suppressors of innate antiviral immune signaling
ATG16L1 InnateDB 55054 100462746 autophagy related 16 like 1 autophagy related 16 like 1 19898471 Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
ATG12 InnateDB 9140 100462745 autophagy related 12 autophagy related 12 17921696 The non-canonical role of Atg family members as suppressors of innate antiviral immune signaling
AIRE InnateDB 326 100621659 autoimmune regulator autoimmune regulator 21628060 Overexpressing autoimmune regulator regulates the expression of toll-like receptors by interacting with their promoters in RAW264.7 cells
AMFR InnateDB 267 100516197 autocrine motility factor receptor autocrine motility factor receptor 25526307 Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a LyPI3K module and promoted by SHIP1
ABCG1 InnateDB 9619 100620416 ATP binding cassette subfamily G member 1 ATP binding cassette subfamily G member 1 20395559 ATP-binding cassette transporter G1 deficiency dysregulates host defense in the lung
ABCA1 InnateDB 19 100152112 ATP binding cassette subfamily A member 1 ATP binding cassette subfamily A member 1 22955730 Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection
ATM InnateDB 472 100101922 ATM serine/threonine kinase ATM serine/threonine kinase 25692705 DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity
AKNA InnateDB 80709 100152364 AT-hook transcription factor AT-hook transcription factor 21606955 Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice
AIP InnateDB 9049 100511065 aryl hydrocarbon receptor interacting protein aryl hydrocarbon receptor interacting protein 25911105 Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon
AHR InnateDB 196 396654 aryl hydrocarbon receptor aryl hydrocarbon receptor 21683686 AhR deficiency impairs expression of LPS-induced inflammatory genes in mice
ARRB2 InnateDB 409 100170767 arrestin beta 2 arrestin beta 2 19783052 Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival
ARG1 InnateDB 383 397115 arginase 1 arginase 1 18978793 Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
ACAP1 InnateDB 9744 100623422 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 17005562 Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation
AQP3 InnateDB 360 100126235 aquaporin 3 (Gill blood group) aquaporin 3 21865318 Defective macrophage function in aquaporin-3 deficiency
APOH InnateDB 350 100522100 apolipoprotein H apolipoprotein H 21965665 Interaction of β2-glycoprotein I with lipopolysaccharide leads to Toll-like receptor 4 (TLR4)-dependent activation of macrophages
APOBEC3B InnateDB 9582 100037939 apolipoprotein B mRNA editing enzyme catalytic subunit 3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B 22108670 Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria
APOA1 InnateDB 335 397691 apolipoprotein A1 apolipoprotein A1 22271762 Endogenous apolipoprotein A-I stabilizes ATP-binding cassette transporter A1 and modulates Toll-like receptor 4 signaling in human macrophages
ANO6 InnateDB 196527 100155593 anoctamin 6 anoctamin 6 25651887 Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages
ANXA4 InnateDB 307 100312960 annexin A4 annexin A4 20237821 Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca2+-dependent manner
ANXA2 InnateDB 302 406192 annexin A2 annexin A2 21115493 Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression
ANXA1 InnateDB 301 396942 annexin A1 annexin A1 25533809 Absence of Annexin A1 impairs host adaptive immunity against Mycobacterium tuberculosis in vivo
ANKRD17 InnateDB 26057 100520501 ankyrin repeat domain 17 ankyrin repeat domain 17 23711367 A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses
ACE InnateDB 1636 613133 angiotensin I converting enzyme angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 20937811 Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus
ACE2 InnateDB 59272 100144303 angiotensin converting enzyme 2 angiotensin converting enzyme 2 22837003 ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
ANGPT1 InnateDB 284 397009 angiopoietin 1 angiopoietin 1 22015631 Angiopoietin-1 but not angiopoietin-2 induces IL-8 synthesis and release by human neutrophils
AAMP InnateDB 14 100621415 angio associated migratory cell protein angio associated migratory cell protein 19535145 A function for AAMP in Nod2-mediated NF-kappaB activation
APCS InnateDB 325 396921 amyloid P component, serum amyloid P component, serum 21278351 Human serum amyloid P functions as a negative regulator of the innate and adaptive immune responses to DNA vaccines
AREG InnateDB 374 397668 amphiregulin amphiregulin 26243875 IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions
AIMP1 InnateDB 9255 100135670 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 21711348 Enhancement of toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells
AHSG InnateDB 197 397585 alpha 2-HS glycoprotein alpha 2-HS glycoprotein 22842477 Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
ANPEP InnateDB 290 397520 alanyl aminopeptidase, membrane alanyl aminopeptidase, membrane 25801433 CD13 restricts TLR4 endocytic signal transduction in inflammation
AKT1 InnateDB 207 100126861 AKT serine/threonine kinase 1 AKT serine/threonine kinase 1 21196185 Functional role of Akt in macrophage-mediated innate immunity
AKAP10 InnateDB 11216 397262 A-kinase anchoring protein 10 A-kinase anchoring protein 10 21247892 Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
AGER InnateDB 177 396591 advanced glycosylation end-product specific receptor advanced glycosylation end-product specific receptor 22386596 RAGE binds C1q and enhances C1q-mediated phagocytosis
ADRB2 InnateDB 154 397357 adrenoceptor beta 2 adrenoceptor beta 2 21683614 β2-Adrenergic agonists bias TLR-2 and NOD2 activated dendritic cells towards inducing an IL-17 immune response
ARL5B InnateDB 221079 100627052 ADP ribosylation factor like GTPase 5B ADP ribosylation factor like GTPase 5B 25451939 Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B
ARF6 InnateDB 382 780425 ADP ribosylation factor 6 ADP ribosylation factor 6 22170068 Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics
ADIPOQ InnateDB 9370 397660 adiponectin, C1Q and collagen domain containing adiponectin, C1Q and collagen domain containing 22948153 Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells
ADCY8 InnateDB 114 100622999 adenylate cyclase 8 adenylate cyclase 8 25368329 Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
ADAR InnateDB 103 100523784 adenosine deaminase RNA specific adenosine deaminase RNA specific 21809195 ADARs: viruses and innate immunity
AP3B1 InnateDB 8546 100049670 adaptor related protein complex 3 subunit beta 1 adaptor related protein complex 3 subunit beta 1 21045126 Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background
ADAM17 InnateDB 6868 397343 ADAM metallopeptidase domain 17 ADAM metallopeptidase domain 17 25461404 Structure of the activating IL-1 receptor signaling complex
ADAM10 InnateDB 102 397345 ADAM metallopeptidase domain 10 ADAM metallopeptidase domain 10 18981120 Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor
AICDA InnateDB 57379 100526050 activation induced cytidine deaminase activation induced cytidine deaminase 24244169 A role for host activation-induced cytidine deaminase in innate immune defense against KSHV
ATF7 InnateDB 11016 100518609 activating transcription factor 7 activating transcription factor 7 26322480 The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory
ATF4 InnateDB 468 100144302 activating transcription factor 4 activating transcription factor 4 22496230 Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein response
ATF3 InnateDB 467 100738612 activating transcription factor 3 activating transcription factor 3 24317040 High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3
ATF2 InnateDB 1386 100513441 activating transcription factor 2 activating transcription factor 2 25368329 Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
ASCC3 InnateDB 10973 100625273 activating signal cointegrator 1 complex subunit 3 activating signal cointegrator 1 complex subunit 3 23781071 A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response
ACO1 InnateDB 48 100628006 aconitase 1 aconitase 1 26190773 Divergent roles of IRAK4-mediated innate immune responses in two experimental models of severe malaria
ACHE InnateDB 43 100621099 acetylcholinesterase (Cartwright blood group) acetylcholinesterase 18385943 The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis
ABL1 InnateDB 25 100524544 ABL proto-oncogene 1, non-receptor tyrosine kinase ABL proto-oncogene 1, non-receptor tyrosine kinase 23325923 c-Abl tyrosine kinase plays a critical role in β2 integrin-dependent neutrophil migration by regulating Vav1 activity
DHCR7 InnateDB 1717 100627707 7-dehydrocholesterol reductase 7-dehydrocholesterol reductase 26938778 Resistin-like molecule α promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation
AZI2 InnateDB 64343 100524397 5-azacytidine induced 2 5-azacytidine induced 2 17142768 NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction
OAS2 InnateDB 4939 595128 2'-5'-oligoadenylate synthetase 2 2'-5'-oligoadenylate synthetase 2 21190483 New insights into the role of RNase L in innate immunity
OAS1 InnateDB 4938 397570 2'-5'-oligoadenylate synthetase 1 2'-5'-oligoadenylate synthetase 1 21190483 New insights into the role of RNase L in innate immunity
DHCR24 InnateDB 1718 100628197 24-dehydrocholesterol reductase 24-dehydrocholesterol reductase 20406300 Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS
RNF31 InnateDB 55072 100158067 ring finger protein 31 ring finger protein 31 19136968 Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells
ITCH InnateDB 83737 102165807 itchy E3 ubiquitin protein ligase itchy E3 ubiquitin protein ligase 22057290 Formation and reaction of O=MnV species in the oxidation of phenolic substrates with H2O2 catalysed by the dinuclear manganese(IV) 1,4,7-trimethyl-1,4,7-triazacyclononane complex [MnIV2(mu-O)3(TMTACN)2](PF6)2
ITGAX InnateDB 3687 100738907 integrin subunit alpha X integrin subunit alpha X 21775452 αvβ3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1
CDK6 InnateDB 1021 100518921 cyclin dependent kinase 6 cyclin dependent kinase 6 21628465 Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6
CALCA InnateDB 796 100579174 calcitonin related polypeptide alpha calcitonin-related polypeptide alpha 20141542 Lipopolysaccharide induces calcitonin gene-related peptide in the RAW264.7 macrophage cell line
PSPC1 Feng et al., 2021 55269 100520511 paraspeckle component 1 paraspeckle component 1 35278697 Regulation of antiviral immune response by African swine fever virus (ASFV)
LDHB Feng et al., 2021 3945 100621540 lactate dehydrogenase B lactate dehydrogenase 35278697 Regulation of antiviral immune response by African swine fever virus (ASFV)
IL24 Feng et al., 2021 11009 100739374 interleukin 24 interleukin 24 35278697 Regulation of antiviral immune response by African swine fever virus (ASFV)
IL20 Feng et al., 2021 50604 100522695 interleukin 20 interleukin 20 35278697 Regulation of antiviral immune response by African swine fever virus (ASFV)
IL12RB1 Feng et al., 2021 3594 100271900 interleukin 12 receptor subunit beta 1 interleukin 12 receptor subunit beta 1 35278697 Regulation of antiviral immune response by African swine fever virus (ASFV)
CREBBP Feng et al., 2021 1387 100620215 CREB binding protein CREB binding protein 35278697 Regulation of antiviral immune response by African swine fever virus (ASFV)
ZYG11B Dawson et al., 2013 79699 100739208 zyg-11 family member B, cell cycle regulator zyg-11 family member B, cell cycle regulator 23676093 Structural and functional annotation of the porcine immunome
ZNF639 Dawson et al., 2013 51193 100623119 zinc finger protein 639 zinc finger protein 639 23676093 Structural and functional annotation of the porcine immunome
ZNF330 Dawson et al., 2013 27309 100511765 zinc finger protein 330 zinc finger protein 330 23676093 Structural and functional annotation of the porcine immunome
ZNF281 Dawson et al., 2013 23528 100523859 zinc finger protein 281 zinc finger protein 281 23676093 Structural and functional annotation of the porcine immunome
ZNF189 Dawson et al., 2013 7743 100515357 zinc finger protein 189 zinc finger protein 189 23676093 Structural and functional annotation of the porcine immunome
ZNFX1 Dawson et al., 2013 57169 100624243 zinc finger NFX1-type containing 1 zinc finger NFX1-type containing 1 23676093 Structural and functional annotation of the porcine immunome
ZMYM1 Dawson et al., 2013 79830 110261141 zinc finger MYM-type containing 1 zinc finger MYM-type containing 1 23676093 Structural and functional annotation of the porcine immunome
ZCWPW1 Dawson et al., 2013 55063 100513075 zinc finger CW-type and PWWP domain containing 1 zinc finger CW-type and PWWP domain containing 1 23676093 Structural and functional annotation of the porcine immunome
ZCCHC2 Dawson et al., 2013 54877 100625613 zinc finger CCHC-type containing 2 zinc finger CCHC-type containing 2 23676093 Structural and functional annotation of the porcine immunome
YIPF6 Dawson et al., 2013 286451 100738646 Yip1 domain family member 6 Yip1 domain family member 6 23676093 Structural and functional annotation of the porcine immunome
YIPF4 Dawson et al., 2013 84272 110260040 Yip1 domain family member 4 Yip1 domain family member 4 23676093 Structural and functional annotation of the porcine immunome
XAF1 Dawson et al., 2013 54739 102159947 XIAP associated factor 1 XIAP associated factor 1 23676093 Structural and functional annotation of the porcine immunome
WBP4 Dawson et al., 2013 11193 110255820 WW domain binding protein 4 WW domain binding protein 4 23676093 Structural and functional annotation of the porcine immunome
VPS54 Dawson et al., 2013 51542 100621212 VPS54 subunit of GARP complex VPS54 subunit of GARP complex 23676093 Structural and functional annotation of the porcine immunome
VCPIP1 Dawson et al., 2013 80124 100621816 valosin containing protein interacting protein 1 valosin containing protein interacting protein 1 23676093 Structural and functional annotation of the porcine immunome
UPF2 Dawson et al., 2013 26019 100621126 UPF2 regulator of nonsense mediated mRNA decay UPF2 regulator of nonsense mediated mRNA decay 23676093 Structural and functional annotation of the porcine immunome
UEVLD Dawson et al., 2013 55293 100524069 UEV and lactate/malate dehyrogenase domains UEV and lactate/malate dehyrogenase domains 23676093 Structural and functional annotation of the porcine immunome
UBXN7 Dawson et al., 2013 26043 100620692 UBX domain protein 7 UBX domain protein 7 23676093 Structural and functional annotation of the porcine immunome
USP8 Dawson et al., 2013 9101 100157546 ubiquitin specific peptidase 8 ubiquitin specific peptidase 8 23676093 Structural and functional annotation of the porcine immunome
USP33 Dawson et al., 2013 23032 100625972 ubiquitin specific peptidase 33 ubiquitin specific peptidase 33 23676093 Structural and functional annotation of the porcine immunome
USP18 Dawson et al., 2013 11274 396777 ubiquitin specific peptidase 18 ubiquitin specific peptidase 18 23676093 Structural and functional annotation of the porcine immunome
USP15 Dawson et al., 2013 9958 100524085 ubiquitin specific peptidase 15 ubiquitin specific peptidase 15 23676093 Structural and functional annotation of the porcine immunome
UBA3 Dawson et al., 2013 9039 100153428 ubiquitin like modifier activating enzyme 3 ubiquitin like modifier activating enzyme 3 23676093 Structural and functional annotation of the porcine immunome
UBE2Q2 Dawson et al., 2013 92912 100621770 ubiquitin conjugating enzyme E2 Q2 ubiquitin conjugating enzyme E2 Q2 23676093 Structural and functional annotation of the porcine immunome
UBE2Q1 Dawson et al., 2013 55585 100156747 ubiquitin conjugating enzyme E2 Q1 ubiquitin conjugating enzyme E2 Q1 23676093 Structural and functional annotation of the porcine immunome
UBE2L6 Dawson et al., 2013 9246 100514753 ubiquitin conjugating enzyme E2 L6 ubiquitin conjugating enzyme E2 L6 23676093 Structural and functional annotation of the porcine immunome
UBE2D1 Dawson et al., 2013 7321 780419 ubiquitin conjugating enzyme E2 D1 ubiquitin conjugating enzyme E2 D1 23676093 Structural and functional annotation of the porcine immunome
UBE2B Dawson et al., 2013 7320 100513527 ubiquitin conjugating enzyme E2 B ubiquitin conjugating enzyme E2 B 23676093 Structural and functional annotation of the porcine immunome
TWF1 Dawson et al., 2013 5756 100523377 twinfilin actin binding protein 1 twinfilin actin binding protein 1 23676093 Structural and functional annotation of the porcine immunome
TDRD7 Dawson et al., 2013 23424 100152652 tudor domain containing 7 tudor domain containing 7 23676093 Structural and functional annotation of the porcine immunome
TSR2 Dawson et al., 2013 90121 100157624 TSR2 ribosome maturation factor TSR2 ribosome maturation factor 23676093 Structural and functional annotation of the porcine immunome
TSFM Dawson et al., 2013 10102 100622167 Ts translation elongation factor, mitochondrial Ts translation elongation factor, mitochondrial 23676093 Structural and functional annotation of the porcine immunome
TRMT11 Dawson et al., 2013 60487 100152782 tRNA methyltransferase 11 homolog tRNA methyltransferase 11 homolog 23676093 Structural and functional annotation of the porcine immunome
TNRC6A Dawson et al., 2013 27327 110258158 trinucleotide repeat containing adaptor 6A trinucleotide repeat containing adaptor 6A 23676093 Structural and functional annotation of the porcine immunome
TNPO1 Dawson et al., 2013 3842 100627484 transportin 1 transportin 1 23676093 Structural and functional annotation of the porcine immunome
TAP1 Dawson et al., 2013 6890 733649 transporter 1, ATP binding cassette subfamily B member transporter 1, ATP binding cassette subfamily B member 23676093 Structural and functional annotation of the porcine immunome
TMEM168 Dawson et al., 2013 64418 100518941 transmembrane protein 168 transmembrane protein 168 23676093 Structural and functional annotation of the porcine immunome
TMEM140 Dawson et al., 2013 55281 100523705 transmembrane protein 140 transmembrane protein 140 23676093 Structural and functional annotation of the porcine immunome
TMEM128 Dawson et al., 2013 85013 100524815 transmembrane protein 128 transmembrane protein 128 23676093 Structural and functional annotation of the porcine immunome
TMBIM6 Dawson et al., 2013 7009 396907 transmembrane BAX inhibitor motif containing 6 transmembrane BAX inhibitor motif containing 6 23676093 Structural and functional annotation of the porcine immunome
TMBIM4 Dawson et al., 2013 51643 100738459 transmembrane BAX inhibitor motif containing 4 transmembrane BAX inhibitor motif containing 4 23676093 Structural and functional annotation of the porcine immunome
TMCO1 Dawson et al., 2013 54499 100151809 transmembrane and coiled-coil domains 1 transmembrane and coiled-coil domains 1 23676093 Structural and functional annotation of the porcine immunome
TSPO Dawson et al., 2013 706 396592 translocator protein translocator protein 23676093 Structural and functional annotation of the porcine immunome
TRERF1 Dawson et al., 2013 55809 100153071 transcriptional regulating factor 1 transcriptional regulating factor 1 23676093 Structural and functional annotation of the porcine immunome
TADA1 Dawson et al., 2013 117143 100155439 transcriptional adaptor 1 transcriptional adaptor 1 23676093 Structural and functional annotation of the porcine immunome
TLK2 Dawson et al., 2013 11011 100515573 tousled like kinase 2 tousled like kinase 2 23676093 Structural and functional annotation of the porcine immunome
TOR3A Dawson et al., 2013 64222 100196908 torsin family 3 member A torsin family 3 member A 23676093 Structural and functional annotation of the porcine immunome
TOR1AIP1 Dawson et al., 2013 26092 102165030 torsin 1A interacting protein 1 torsin 1A interacting protein 1 23676093 Structural and functional annotation of the porcine immunome
TIA1 Dawson et al., 2013 7072 100736894 TIA1 cytotoxic granule associated RNA binding protein TIA1 cytotoxic granule associated RNA binding protein 23676093 Structural and functional annotation of the porcine immunome
TREX1 Dawson et al., 2013 11277 100155669 three prime repair exonuclease 1 three prime repair exonuclease 1 23676093 Structural and functional annotation of the porcine immunome
TTC1 Dawson et al., 2013 7265 100519063 tetratricopeptide repeat domain 1 tetratricopeptide repeat domain 1 23676093 Structural and functional annotation of the porcine immunome
TRANK1 Dawson et al., 2013 9881 102163142 tetratricopeptide repeat and ankyrin repeat containing 1 tetratricopeptide repeat and ankyrin repeat containing 1 23676093 Structural and functional annotation of the porcine immunome
TSPAN13 Dawson et al., 2013 27075 100624728 tetraspanin 13 tetraspanin 13 23676093 Structural and functional annotation of the porcine immunome
TEX261 Dawson et al., 2013 113419 100522925 testis expressed 261 testis expressed 261 23676093 Structural and functional annotation of the porcine immunome
TERF2IP Dawson et al., 2013 54386 100521624 TERF2 interacting protein TERF2 interacting protein 23676093 Structural and functional annotation of the porcine immunome
TBC1D22B Dawson et al., 2013 55633 100512665 TBC1 domain family member 22B TBC1 domain family member 22B 23676093 Structural and functional annotation of the porcine immunome
TBPL1 Dawson et al., 2013 9519 100517563 TATA-box binding protein like 1 TATA-box binding protein like 1 23676093 Structural and functional annotation of the porcine immunome
TAPBP Dawson et al., 2013 6892 100155428 TAP binding protein TAP binding protein 23676093 Structural and functional annotation of the porcine immunome
TAOK3 Dawson et al., 2013 51347 100154763 TAO kinase 3 TAO kinase 3 23676093 Structural and functional annotation of the porcine immunome
TAOK1 Dawson et al., 2013 57551 100622172 TAO kinase 1 TAO kinase 1 23676093 Structural and functional annotation of the porcine immunome
SNTB1 Dawson et al., 2013 6641 100154009 syntrophin beta 1 syntrophin beta 1 23676093 Structural and functional annotation of the porcine immunome
STX17 Dawson et al., 2013 55014 100157063 syntaxin 17 syntaxin 17 23676093 Structural and functional annotation of the porcine immunome
SUV39H2 Dawson et al., 2013 79723 664651 SUV39H2 histone lysine methyltransferase SUV39H2 histone lysine methyltransferase 23676093 Structural and functional annotation of the porcine immunome
SOCS4 Dawson et al., 2013 122809 100302366 suppressor of cytokine signaling 4 suppressor of cytokine signaling 4 23676093 Structural and functional annotation of the porcine immunome
SENP3 Dawson et al., 2013 26168 100625547 SUMO specific peptidase 3 SUMO specific peptidase 3 23676093 Structural and functional annotation of the porcine immunome
SDHB Dawson et al., 2013 6390 414412 succinate dehydrogenase complex iron sulfur subunit B succinate dehydrogenase complex iron sulfur subunit B 23676093 Structural and functional annotation of the porcine immunome
SMCHD1 Dawson et al., 2013 23347 100627122 structural maintenance of chromosomes flexible hinge domain containing 1 structural maintenance of chromosomes flexible hinge domain containing 1 23676093 Structural and functional annotation of the porcine immunome
STRN3 Dawson et al., 2013 29966 100624265 striatin 3 striatin 3 23676093 Structural and functional annotation of the porcine immunome
SBNO1 Dawson et al., 2013 55206 100158131 strawberry notch homolog 1 strawberry notch homolog 1 23676093 Structural and functional annotation of the porcine immunome
SAMD8 Dawson et al., 2013 142891 100151793 sterile alpha motif domain containing 8 sterile alpha motif domain containing 8 23676093 Structural and functional annotation of the porcine immunome
SUPT4H1 Dawson et al., 2013 6827 100515097 SPT4 homolog, DSIF elongation factor subunit SPT4 homolog, DSIF elongation factor subunit 23676093 Structural and functional annotation of the porcine immunome
SAT1 Dawson et al., 2013 6303 397645 spermidine/spermine N1-acetyltransferase 1 spermidine/spermine N1-acetyltransferase 1 23676093 Structural and functional annotation of the porcine immunome
SPAG9 Dawson et al., 2013 9043 100518147 sperm associated antigen 9 sperm associated antigen 9 23676093 Structural and functional annotation of the porcine immunome
SP110 Dawson et al., 2013 3431 100519278 SP110 nuclear body protein SP110 nuclear body protein 23676093 Structural and functional annotation of the porcine immunome
SNX6 Dawson et al., 2013 58533 100154775 sorting nexin 6 sorting nexin 6 23676093 Structural and functional annotation of the porcine immunome
SNX10 Dawson et al., 2013 29887 100520876 sorting nexin 10 sorting nexin 10 23676093 Structural and functional annotation of the porcine immunome
SLC7A3 Dawson et al., 2013 84889 100171387 solute carrier family 7 member 3 solute carrier family 7 member 3 23676093 Structural and functional annotation of the porcine immunome
SLC38A2 Dawson et al., 2013 54407 100525644 solute carrier family 38 member 2 solute carrier family 38 member 2 23676093 Structural and functional annotation of the porcine immunome
SLC33A1 Dawson et al., 2013 9197 100625667 solute carrier family 33 member 1 solute carrier family 33 member 1 23676093 Structural and functional annotation of the porcine immunome
SLC30A7 Dawson et al., 2013 148867 100156498 solute carrier family 30 member 7 solute carrier family 30 member 7 23676093 Structural and functional annotation of the porcine immunome
SLC30A6 Dawson et al., 2013 55676 100170144 solute carrier family 30 member 6 solute carrier family 30 member 6 23676093 Structural and functional annotation of the porcine immunome
SLC26A6 Dawson et al., 2013 65010 497236 solute carrier family 26 member 6 solute carrier family 26 member 6 23676093 Structural and functional annotation of the porcine immunome
SLC26A3 Dawson et al., 2013 1811 100170644 solute carrier family 26 member 3 solute carrier family 26 member 3 23676093 Structural and functional annotation of the porcine immunome
SLC25A38 Dawson et al., 2013 54977 100622220 solute carrier family 25 member 38 solute carrier family 25 member 38 23676093 Structural and functional annotation of the porcine immunome
SLC25A28 Dawson et al., 2013 81894 100526017 solute carrier family 25 member 28 solute carrier family 25 member 28 23676093 Structural and functional annotation of the porcine immunome
SMG8 Dawson et al., 2013 55181 100624639 SMG8 nonsense mediated mRNA decay factor SMG8 nonsense mediated mRNA decay factor 23676093 Structural and functional annotation of the porcine immunome
SPPL2A Dawson et al., 2013 84888 100522175 signal peptide peptidase like 2A signal peptide peptidase like 2A 23676093 Structural and functional annotation of the porcine immunome
SIPA1L1 Dawson et al., 2013 26037 100157762 signal induced proliferation associated 1 like 1 signal induced proliferation associated 1 like 1 23676093 Structural and functional annotation of the porcine immunome
SHISA5 Dawson et al., 2013 51246 100151983 shisa family member 5 shisa family member 5 23676093 Structural and functional annotation of the porcine immunome
SH3BGRL Dawson et al., 2013 6451 100520772 SH3 domain binding glutamate rich protein like SH3 domain binding glutamate rich protein like 23676093 Structural and functional annotation of the porcine immunome
SETDB1 Dawson et al., 2013 9869 100157920 SET domain bifurcated histone lysine methyltransferase 1 SET domain bifurcated histone lysine methyltransferase 1 23676093 Structural and functional annotation of the porcine immunome
SERPINB1 Dawson et al., 2013 1992 100155145 serpin family B member 1 serpin family B member 1 23676093 Structural and functional annotation of the porcine immunome
SETX Dawson et al., 2013 23064 100511239 senataxin senataxin 23676093 Structural and functional annotation of the porcine immunome
SEMA4A Dawson et al., 2013 64218 100157147 semaphorin 4A semaphorin 4A 23676093 Structural and functional annotation of the porcine immunome
SECISBP2 Dawson et al., 2013 79048 100153797 SECIS binding protein 2 SECIS binding protein 2 23676093 Structural and functional annotation of the porcine immunome
SUDS3 Dawson et al., 2013 64426 100153179 SDS3 homolog, SIN3A corepressor complex component SDS3 homolog, SIN3A corepressor complex component 23676093 Structural and functional annotation of the porcine immunome
RUFY3 Dawson et al., 2013 22902 100517663 RUN and FYVE domain containing 3 RUN and FYVE domain containing 3 23676093 Structural and functional annotation of the porcine immunome
POLR3GL Dawson et al., 2013 84265 100152157 RNA polymerase III subunit GL RNA polymerase III subunit GL 23676093 Structural and functional annotation of the porcine immunome
POLR3C Dawson et al., 2013 10623 100516367 RNA polymerase III subunit C RNA polymerase III subunit C 23676093 Structural and functional annotation of the porcine immunome
POLR2J Dawson et al., 2013 5439 100521614 RNA polymerase II subunit J RNA polymerase II subunit J 23676093 Structural and functional annotation of the porcine immunome
RPAP3 Dawson et al., 2013 79657 100623899 RNA polymerase II associated protein 3 RNA polymerase II associated protein 3 23676093 Structural and functional annotation of the porcine immunome
RBM26 Dawson et al., 2013 64062 100153235 RNA binding motif protein 26 RNA binding motif protein 26 23676093 Structural and functional annotation of the porcine immunome
RBM18 Dawson et al., 2013 92400 100154045 RNA binding motif protein 18 RNA binding motif protein 18 23676093 Structural and functional annotation of the porcine immunome
RNF24 Dawson et al., 2013 11237 100519342 ring finger protein 24 ring finger protein 24 23676093 Structural and functional annotation of the porcine immunome
RNF146 Dawson et al., 2013 81847 100512692 ring finger protein 146 ring finger protein 146 23676093 Structural and functional annotation of the porcine immunome
RNF144B Dawson et al., 2013 255488 100155665 ring finger protein 144B ring finger protein 144B 23676093 Structural and functional annotation of the porcine immunome
RNF114 Dawson et al., 2013 55905 414917 ring finger protein 114 ring finger protein 114 23676093 Structural and functional annotation of the porcine immunome
RNASEH2B Dawson et al., 2013 79621 100625239 ribonuclease H2 subunit B ribonuclease H2 subunit B 23676093 Structural and functional annotation of the porcine immunome
RHPN2 Dawson et al., 2013 85415 100620673 rhophilin Rho GTPase binding protein 2 rhophilin Rho GTPase binding protein 2 23676093 Structural and functional annotation of the porcine immunome
RHBDD1 Dawson et al., 2013 84236 100512869 rhomboid domain containing 1 rhomboid domain containing 1 23676093 Structural and functional annotation of the porcine immunome
RSF1 Dawson et al., 2013 51773 100217384 remodeling and spacing factor 1 remodeling and spacing factor 1 23676093 Structural and functional annotation of the porcine immunome
RTP4 Dawson et al., 2013 64108 110256385 receptor transporter protein 4 receptor transporter protein 4 23676093 Structural and functional annotation of the porcine immunome
REC8 Dawson et al., 2013 9985 100152822 REC8 meiotic recombination protein REC8 meiotic recombination protein 23676093 Structural and functional annotation of the porcine immunome
RBBP6 Dawson et al., 2013 5930 100521783 RB binding protein 6, ubiquitin ligase RB binding protein 6, ubiquitin ligase 23676093 Structural and functional annotation of the porcine immunome
RRAGC Dawson et al., 2013 64121 100513798 Ras related GTP binding C Ras related GTP binding C 23676093 Structural and functional annotation of the porcine immunome
RASAL2 Dawson et al., 2013 9462 106504097 RAS protein activator like 2 RAS protein activator like 2 23676093 Structural and functional annotation of the porcine immunome
RHOC Dawson et al., 2013 389 100520019 ras homolog family member C ras homolog family member C 23676093 Structural and functional annotation of the porcine immunome
RAP2C Dawson et al., 2013 57826 100511975 RAP2C, member of RAS oncogene family RAP2C, member of RAS oncogene family 23676093 Structural and functional annotation of the porcine immunome
RAB3GAP1 Dawson et al., 2013 22930 100152771 RAB3 GTPase activating protein catalytic subunit 1 RAB3 GTPase activating protein catalytic subunit 1 23676093 Structural and functional annotation of the porcine immunome
PTPN12 Dawson et al., 2013 5782 100625763 protein tyrosine phosphatase non-receptor type 12 protein tyrosine phosphatase non-receptor type 12 23676093 Structural and functional annotation of the porcine immunome
PPM1K Dawson et al., 2013 152926 110262190 protein phosphatase, Mg2+/Mn2+ dependent 1K protein phosphatase, Mg2+/Mn2+ dependent 1K 23676093 Structural and functional annotation of the porcine immunome
PPTC7 Dawson et al., 2013 160760 100513685 protein phosphatase targeting COQ7 protein phosphatase targeting COQ7 23676093 Structural and functional annotation of the porcine immunome
PPP2R5C Dawson et al., 2013 5527 100620346 protein phosphatase 2 regulatory subunit B'gamma protein phosphatase 2 regulatory subunit B'gamma 23676093 Structural and functional annotation of the porcine immunome
PPP2R5E Dawson et al., 2013 5529 100525377 protein phosphatase 2 regulatory subunit B'epsilon protein phosphatase 2 regulatory subunit B'epsilon 23676093 Structural and functional annotation of the porcine immunome
PPP2R2A Dawson et al., 2013 5520 397090 protein phosphatase 2 regulatory subunit Balpha protein phosphatase 2 regulatory subunit Balpha 23676093 Structural and functional annotation of the porcine immunome
PDIA3 Dawson et al., 2013 2923 100156204 protein disulfide isomerase family A member 3 protein disulfide isomerase family A member 3 23676093 Structural and functional annotation of the porcine immunome
PSMF1 Dawson et al., 2013 9491 100152620 proteasome inhibitor subunit 1 proteasome inhibitor subunit 1 23676093 Structural and functional annotation of the porcine immunome
PSME4 Dawson et al., 2013 23198 100517820 proteasome activator subunit 4 proteasome activator subunit 4 23676093 Structural and functional annotation of the porcine immunome
PSME2 Dawson et al., 2013 5721 397522 proteasome activator subunit 2 proteasome activator subunit 2 23676093 Structural and functional annotation of the porcine immunome
PSME1 Dawson et al., 2013 5720 397572 proteasome activator subunit 1 proteasome activator subunit 1 23676093 Structural and functional annotation of the porcine immunome
PSMB9 Dawson et al., 2013 5698 654294 proteasome 20S subunit beta 9 proteasome 20S subunit beta 9 23676093 Structural and functional annotation of the porcine immunome
PSMB4 Dawson et al., 2013 5692 100153923 proteasome 20S subunit beta 4 proteasome 20S subunit beta 4 23676093 Structural and functional annotation of the porcine immunome
PSMB2 Dawson et al., 2013 5690 100622444 proteasome 20S subunit beta 2 proteasome 20S subunit beta 2 23676093 Structural and functional annotation of the porcine immunome
PSMB10 Dawson et al., 2013 5699 733626 proteasome 20S subunit beta 10 proteasome 20S subunit beta 10 23676093 Structural and functional annotation of the porcine immunome
PSMA6 Dawson et al., 2013 5687 100156790 proteasome 20S subunit alpha 6 proteasome 20S subunit alpha 6 23676093 Structural and functional annotation of the porcine immunome
PSMA5 Dawson et al., 2013 5686 497063 proteasome 20S subunit alpha 5 proteasome 20S subunit alpha 5 23676093 Structural and functional annotation of the porcine immunome
PSMA3 Dawson et al., 2013 5684 100154408 proteasome 20S subunit alpha 3 proteasome 20S subunit alpha 3 23676093 Structural and functional annotation of the porcine immunome
PSMA2 Dawson et al., 2013 5683 100620420 proteasome 20S subunit alpha 2 proteasome 20S subunit alpha 2 23676093 Structural and functional annotation of the porcine immunome
PSMA1 Dawson et al., 2013 5682 100516779 proteasome 20S subunit alpha 1 proteasome 20S subunit alpha 1 23676093 Structural and functional annotation of the porcine immunome
PTGES3 Dawson et al., 2013 10728 100155956 prostaglandin E synthase 3 prostaglandin E synthase 3 23676093 Structural and functional annotation of the porcine immunome
PSTPIP2 Dawson et al., 2013 9050 100519694 proline-serine-threonine phosphatase interacting protein 2 proline-serine-threonine phosphatase interacting protein 2 23676093 Structural and functional annotation of the porcine immunome
PRRT3 Dawson et al., 2013 285368 100156687 proline rich transmembrane protein 3 proline rich transmembrane protein 3 23676093 Structural and functional annotation of the porcine immunome
PREB Dawson et al., 2013 10113 100522734 prolactin regulatory element binding prolactin regulatory element binding 23676093 Structural and functional annotation of the porcine immunome
PNPT1 Dawson et al., 2013 87178 100642182 polyribonucleotide nucleotidyltransferase 1 polyribonucleotide nucleotidyltransferase 1 23676093 Structural and functional annotation of the porcine immunome
PHC3 Dawson et al., 2013 80012 100626327 polyhomeotic homolog 3 polyhomeotic homolog 3 23676093 Structural and functional annotation of the porcine immunome
PCGF5 Dawson et al., 2013 84333 100522283 polycomb group ring finger 5 polycomb group ring finger 5 23676093 Structural and functional annotation of the porcine immunome
PARP9 Dawson et al., 2013 83666 100519390 poly(ADP-ribose) polymerase family member 9 poly(ADP-ribose) polymerase family member 9 23676093 Structural and functional annotation of the porcine immunome
PARP3 Dawson et al., 2013 10039 100620838 poly(ADP-ribose) polymerase family member 3 poly(ADP-ribose) polymerase family member 3 23676093 Structural and functional annotation of the porcine immunome
PARP12 Dawson et al., 2013 64761 100515805 poly(ADP-ribose) polymerase family member 12 poly(ADP-ribose) polymerase family member 12 23676093 Structural and functional annotation of the porcine immunome
PARP11 Dawson et al., 2013 57097 100524437 poly(ADP-ribose) polymerase family member 11 poly(ADP-ribose) polymerase family member 11 23676093 Structural and functional annotation of the porcine immunome
PAN3 Dawson et al., 2013 255967 100514180 poly(A) specific ribonuclease subunit PAN3 poly(A) specific ribonuclease subunit PAN3 23676093 Structural and functional annotation of the porcine immunome
PAPOLA Dawson et al., 2013 10914 100156323 poly(A) polymerase alpha poly(A) polymerase alpha 23676093 Structural and functional annotation of the porcine immunome
PLEKHA3 Dawson et al., 2013 65977 100154010 pleckstrin homology domain containing A3 pleckstrin homology domain containing A3 23676093 Structural and functional annotation of the porcine immunome
PLAC8 Dawson et al., 2013 51316 100525175 placenta associated 8 placenta associated 8 23676093 Structural and functional annotation of the porcine immunome
PIM2 Dawson et al., 2013 11040 100621339 Pim-2 proto-oncogene, serine/threonine kinase Pim-2 proto-oncogene, serine/threonine kinase 23676093 Structural and functional annotation of the porcine immunome
PLA2G6 Dawson et al., 2013 8398 100514711 phospholipase A2 group VI phospholipase A2 group VI 23676093 Structural and functional annotation of the porcine immunome
PGD Dawson et al., 2013 5226 397546 phosphogluconate dehydrogenase phosphogluconate dehydrogenase 23676093 Structural and functional annotation of the porcine immunome
PDE8A Dawson et al., 2013 5151 100514527 phosphodiesterase 8A phosphodiesterase 8A 23676093 Structural and functional annotation of the porcine immunome
PI4K2B Dawson et al., 2013 55300 100623115 phosphatidylinositol 4-kinase type 2 beta phosphatidylinositol 4-kinase type 2 beta 23676093 Structural and functional annotation of the porcine immunome
PHF20L1 Dawson et al., 2013 51105 100153657 PHD finger protein 20 like 1 PHD finger protein 20 like 1 23676093 Structural and functional annotation of the porcine immunome
PHF11 Dawson et al., 2013 51131 100518446 PHD finger protein 11 PHD finger protein 11 23676093 Structural and functional annotation of the porcine immunome
PHRF1 Dawson et al., 2013 57661 100512701 PHD and ring finger domains 1 PHD and ring finger domains 1 23676093 Structural and functional annotation of the porcine immunome
PGAM5 Dawson et al., 2013 192111 106508765 PGAM family member 5, mitochondrial serine/threonine protein phosphatase PGAM family member 5, mitochondrial serine/threonine protein phosphatase 23676093 Structural and functional annotation of the porcine immunome
PEX13 Dawson et al., 2013 5194 100739593 peroxisomal biogenesis factor 13 peroxisomal biogenesis factor 13 23676093 Structural and functional annotation of the porcine immunome
PAK1 Dawson et al., 2013 5058 100525766 p21 (RAC1) activated kinase 1 p21 (RAC1) activated kinase 1 23676093 Structural and functional annotation of the porcine immunome
OSBPL9 Dawson et al., 2013 114883 100517719 oxysterol binding protein like 9 oxysterol binding protein like 9 23676093 Structural and functional annotation of the porcine immunome
OTUD4 Dawson et al., 2013 54726 100524693 OTU deubiquitinase 4 OTU deubiquitinase 4 23676093 Structural and functional annotation of the porcine immunome
OSTM1 Dawson et al., 2013 28962 100049681 osteoclastogenesis associated transmembrane protein 1 osteoclastogenesis associated transmembrane protein 1 23676093 Structural and functional annotation of the porcine immunome
NUDT7 Dawson et al., 2013 283927 100738827 nudix hydrolase 7 nudix hydrolase 7 23676093 Structural and functional annotation of the porcine immunome
NUDT18 Dawson et al., 2013 79873 100156061 nudix hydrolase 18 nudix hydrolase 18 23676093 Structural and functional annotation of the porcine immunome
NCOA1 Dawson et al., 2013 8648 574068 nuclear receptor coactivator 1 nuclear receptor coactivator 1 23676093 Structural and functional annotation of the porcine immunome
NPAT Dawson et al., 2013 4863 100627195 nuclear protein, coactivator of histone transcription nuclear protein, coactivator of histone transcription 23676093 Structural and functional annotation of the porcine immunome
NMT1 Dawson et al., 2013 4836 100524705 N-myristoyltransferase 1 N-myristoyltransferase 1 23676093 Structural and functional annotation of the porcine immunome
NMI Dawson et al., 2013 9111 100621233 N-myc and STAT interactor N-myc and STAT interactor 23676093 Structural and functional annotation of the porcine immunome
NBN Dawson et al., 2013 4683 100153233 nibrin nibrin 23676093 Structural and functional annotation of the porcine immunome
NHLRC2 Dawson et al., 2013 374354 100155569 NHL repeat containing 2 NHL repeat containing 2 23676093 Structural and functional annotation of the porcine immunome
NGLY1 Dawson et al., 2013 55768 100522951 N-glycanase 1 N-glycanase 1 23676093 Structural and functional annotation of the porcine immunome
NEIL2 Dawson et al., 2013 252969 100624483 nei like DNA glycosylase 2 nei like DNA glycosylase 2 23676093 Structural and functional annotation of the porcine immunome
N4BP1 Dawson et al., 2013 9683 100520431 NEDD4 binding protein 1 NEDD4 binding protein 1 23676093 Structural and functional annotation of the porcine immunome
NEDD1 Dawson et al., 2013 121441 100514234 NEDD1 gamma-tubulin ring complex targeting factor NEDD1 gamma-tubulin ring complex targeting factor 23676093 Structural and functional annotation of the porcine immunome
NCK1 Dawson et al., 2013 4690 100192438 NCK adaptor protein 1 NCK adaptor protein 1 23676093 Structural and functional annotation of the porcine immunome
NDUFAB1 Dawson et al., 2013 4706 100312976 NADH:ubiquinone oxidoreductase subunit AB1 NADH:ubiquinone oxidoreductase subunit AB1 23676093 Structural and functional annotation of the porcine immunome
NANS Dawson et al., 2013 54187 100155883 N-acetylneuraminate synthase N-acetylneuraminate synthase 23676093 Structural and functional annotation of the porcine immunome
NAGK Dawson et al., 2013 55577 100523729 N-acetylglucosamine kinase N-acetylglucosamine kinase 23676093 Structural and functional annotation of the porcine immunome
MORC3 Dawson et al., 2013 23515 100513379 MORC family CW-type zinc finger 3 MORC family CW-type zinc finger 3 23676093 Structural and functional annotation of the porcine immunome
MAD2L2 Dawson et al., 2013 10459 100736650 mitotic arrest deficient 2 like 2 mitotic arrest deficient 2 like 2 23676093 Structural and functional annotation of the porcine immunome
MAP3K2 Dawson et al., 2013 10746 100621234 mitogen-activated protein kinase kinase kinase 2 mitogen-activated protein kinase kinase kinase 2 23676093 Structural and functional annotation of the porcine immunome
MTRF1L Dawson et al., 2013 54516 100514202 mitochondrial translation release factor 1 like mitochondrial translation release factor 1 like 23676093 Structural and functional annotation of the porcine immunome
MRPL32 Dawson et al., 2013 64983 396626 mitochondrial ribosomal protein L32 mitochondrial ribosomal protein L32 23676093 Structural and functional annotation of the porcine immunome
MIER1 Dawson et al., 2013 57708 100621902 MIER1 transcriptional regulator MIER1 transcriptional regulator 23676093 Structural and functional annotation of the porcine immunome
METTL1 Dawson et al., 2013 4234 100622469 methyltransferase 1, tRNA methylguanosine methyltransferase 1, tRNA methylguanosine 23676093 Structural and functional annotation of the porcine immunome
MTF2 Dawson et al., 2013 22823 100156808 metal response element binding transcription factor 2 metal response element binding transcription factor 2 23676093 Structural and functional annotation of the porcine immunome
MED13 Dawson et al., 2013 9969 100628203 mediator complex subunit 13 mediator complex subunit 13 23676093 Structural and functional annotation of the porcine immunome
MCL1 Dawson et al., 2013 4170 397648 MCL1 apoptosis regulator, BCL2 family member MCL1 apoptosis regulator, BCL2 family member 23676093 Structural and functional annotation of the porcine immunome
LAMP2 Dawson et al., 2013 3920 100154598 lysosomal associated membrane protein 2 lysosomal associated membrane protein 2 23676093 Structural and functional annotation of the porcine immunome
LIN52 Dawson et al., 2013 91750 100157325 lin-52 DREAM MuvB core complex component lin-52 DREAM MuvB core complex component 23676093 Structural and functional annotation of the porcine immunome
LAP3 Dawson et al., 2013 51056 100739583 leucine aminopeptidase 3 leucine aminopeptidase 3 23676093 Structural and functional annotation of the porcine immunome
LEMD3 Dawson et al., 2013 23592 100511508 LEM domain containing 3 LEM domain containing 3 23676093 Structural and functional annotation of the porcine immunome
LMAN2L Dawson et al., 2013 81562 100627779 lectin, mannose binding 2 like lectin, mannose binding 2 like 23676093 Structural and functional annotation of the porcine immunome
LCK Dawson et al., 2013 3932 100233188 LCK proto-oncogene, Src family tyrosine kinase LCK proto-oncogene, Src family tyrosine kinase 23676093 Structural and functional annotation of the porcine immunome
LAMTOR3 Dawson et al., 2013 8649 100526122 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 23676093 Structural and functional annotation of the porcine immunome
KYNU Dawson et al., 2013 8942 100521160 kynureninase kynureninase 23676093 Structural and functional annotation of the porcine immunome
KRAS Dawson et al., 2013 3845 100518251 KRAS proto-oncogene, GTPase KRAS proto-oncogene, GTPase 23676093 Structural and functional annotation of the porcine immunome
KIN Dawson et al., 2013 22944 110255716 Kin17 DNA and RNA binding protein Kin17 DNA and RNA binding protein 23676093 Structural and functional annotation of the porcine immunome
KHNYN Dawson et al., 2013 23351 100158093 KH and NYN domain containing KH and NYN domain containing 23676093 Structural and functional annotation of the porcine immunome
KPNA4 Dawson et al., 2013 3840 100620632 karyopherin subunit alpha 4 karyopherin subunit alpha 4 23676093 Structural and functional annotation of the porcine immunome
ISG20L2 Dawson et al., 2013 81875 100157573 interferon stimulated exonuclease gene 20 like 2 interferon stimulated exonuclease gene 20 like 2 23676093 Structural and functional annotation of the porcine immunome
IFRD2 Dawson et al., 2013 7866 100155668 interferon related developmental regulator 2 interferon related developmental regulator 2 23676093 Structural and functional annotation of the porcine immunome
IRF2BPL Dawson et al., 2013 64207 100152768 interferon regulatory factor 2 binding protein like interferon regulatory factor 2 binding protein like 23676093 Structural and functional annotation of the porcine immunome
IRF2BP2 Dawson et al., 2013 359948 110256877 interferon regulatory factor 2 binding protein 2 interferon regulatory factor 2 binding protein 2 23676093 Structural and functional annotation of the porcine immunome
IFNLR1 Dawson et al., 2013 163702 100622120 interferon lambda receptor 1 interferon lambda receptor 1 23676093 Structural and functional annotation of the porcine immunome
IFNK Dawson et al., 2013 56832 100303725 interferon kappa interferon kappa 23676093 Structural and functional annotation of the porcine immunome
IFITM5 Dawson et al., 2013 387733 100518184 interferon induced transmembrane protein 5 interferon induced transmembrane protein 5 23676093 Structural and functional annotation of the porcine immunome
IFITM10 Dawson et al., 2013 402778 110259214 interferon induced transmembrane protein 10 interferon induced transmembrane protein 10 23676093 Structural and functional annotation of the porcine immunome
IFI44L Dawson et al., 2013 10964 100511267 interferon induced protein 44 like interferon induced protein 44 like 23676093 Structural and functional annotation of the porcine immunome
IFI44 Dawson et al., 2013 10561 100525523 interferon induced protein 44 interferon induced protein 44 23676093 Structural and functional annotation of the porcine immunome
IFI35 Dawson et al., 2013 3430 100624758 interferon induced protein 35 interferon induced protein 35 23676093 Structural and functional annotation of the porcine immunome
IFNAR2 Dawson et al., 2013 3455 100533555 interferon alpha and beta receptor subunit 2 interferon alpha and beta receptor subunit 2 23676093 Structural and functional annotation of the porcine immunome
ICAM2 Dawson et al., 2013 3384 414387 intercellular adhesion molecule 2 intercellular adhesion molecule 2 23676093 Structural and functional annotation of the porcine immunome
ITLN2 Dawson et al., 2013 142683 100144619 intelectin 2 intelectin 2 23676093 Structural and functional annotation of the porcine immunome
INTS6 Dawson et al., 2013 26512 100156695 integrator complex subunit 6 integrator complex subunit 6 23676093 Structural and functional annotation of the porcine immunome
INTS2 Dawson et al., 2013 57508 100525182 integrator complex subunit 2 integrator complex subunit 2 23676093 Structural and functional annotation of the porcine immunome
INTS12 Dawson et al., 2013 57117 100625394 integrator complex subunit 12 integrator complex subunit 12 23676093 Structural and functional annotation of the porcine immunome
ITM2C Dawson et al., 2013 81618 100144481 integral membrane protein 2C integral membrane protein 2C 23676093 Structural and functional annotation of the porcine immunome
INSIG2 Dawson et al., 2013 51141 100170127 insulin induced gene 2 insulin induced gene 2 23676093 Structural and functional annotation of the porcine immunome
INPP1 Dawson et al., 2013 3628 100514878 inositol polyphosphate-1-phosphatase inositol polyphosphate-1-phosphatase 23676093 Structural and functional annotation of the porcine immunome
PPA1 Dawson et al., 2013 5464 100155201 inorganic pyrophosphatase 1 inorganic pyrophosphatase 1 23676093 Structural and functional annotation of the porcine immunome
IMMP1L Dawson et al., 2013 196294 100514893 inner mitochondrial membrane peptidase subunit 1 inner mitochondrial membrane peptidase subunit 1 23676093 Structural and functional annotation of the porcine immunome
IRGC Dawson et al., 2013 56269 100462753 immunity related GTPase cinema immunity related GTPase cinema 23676093 Structural and functional annotation of the porcine immunome
IFI30 Dawson et al., 2013 10437 100174943 IFI30 lysosomal thiol reductase IFI30 lysosomal thiol reductase 23676093 Structural and functional annotation of the porcine immunome
HEXB Dawson et al., 2013 3074 396958 hexosaminidase subunit beta hexosaminidase subunit beta 23676093 Structural and functional annotation of the porcine immunome
HK3 Dawson et al., 2013 3101 100522855 hexokinase 3 hexokinase 3 23676093 Structural and functional annotation of the porcine immunome
HSH2D Dawson et al., 2013 84941 100511370 hematopoietic SH2 domain containing hematopoietic SH2 domain containing 23676093 Structural and functional annotation of the porcine immunome
HERC6 Dawson et al., 2013 55008 100626657 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 23676093 Structural and functional annotation of the porcine immunome
HSPB11 Dawson et al., 2013 51668 100621426 heat shock protein family B (small) member 11 heat shock protein family B (small) member 11 23676093 Structural and functional annotation of the porcine immunome
HSPA13 Dawson et al., 2013 6782 100152073 heat shock protein family A (Hsp70) member 13 heat shock protein family A (Hsp70) member 13 23676093 Structural and functional annotation of the porcine immunome
HAX1 Dawson et al., 2013 10456 100739544 HCLS1 associated protein X-1 HCLS1 associated protein X-1 23676093 Structural and functional annotation of the porcine immunome
GIMAP1 Dawson et al., 2013 170575 110257620 GTPase, IMAP family member 1 GTPase, IMAP family member 1 23676093 Structural and functional annotation of the porcine immunome
GTPBP2 Dawson et al., 2013 54676 100514413 GTP binding protein 2 GTP binding protein 2 23676093 Structural and functional annotation of the porcine immunome
GZMB Dawson et al., 2013 3002 100233184 granzyme B granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 23676093 Structural and functional annotation of the porcine immunome
GPN2 Dawson et al., 2013 54707 110255194 GPN-loop GTPase 2 GPN-loop GTPase 2 23676093 Structural and functional annotation of the porcine immunome
GOSR2 Dawson et al., 2013 9570 100519332 golgi SNAP receptor complex member 2 golgi SNAP receptor complex member 2 23676093 Structural and functional annotation of the porcine immunome
GATC Dawson et al., 2013 283459 100153423 glutamyl-tRNA amidotransferase subunit C glutamyl-tRNA amidotransferase subunit C 23676093 Structural and functional annotation of the porcine immunome
GLS Dawson et al., 2013 2744 399525 glutaminase glutaminase 23676093 Structural and functional annotation of the porcine immunome
GRM8 Dawson et al., 2013 2918 100524120 glutamate metabotropic receptor 8 glutamate metabotropic receptor 8 23676093 Structural and functional annotation of the porcine immunome
GNPDA2 Dawson et al., 2013 132789 100516092 glucosamine-6-phosphate deaminase 2 glucosamine-6-phosphate deaminase 2 23676093 Structural and functional annotation of the porcine immunome
GMFB Dawson et al., 2013 2764 100625819 glia maturation factor beta glia maturation factor beta 23676093 Structural and functional annotation of the porcine immunome
GPHN Dawson et al., 2013 10243 100153443 gephyrin gephyrin 23676093 Structural and functional annotation of the porcine immunome
GPBP1L1 Dawson et al., 2013 60313 100622335 GC-rich promoter binding protein 1 like 1 GC-rich promoter binding protein 1 like 1 23676093 Structural and functional annotation of the porcine immunome
GPBP1 Dawson et al., 2013 65056 100521344 GC-rich promoter binding protein 1 GC-rich promoter binding protein 1 23676093 Structural and functional annotation of the porcine immunome
GM2A Dawson et al., 2013 2760 100515283 ganglioside GM2 activator ganglioside GM2 activator 23676093 Structural and functional annotation of the porcine immunome
GGH Dawson et al., 2013 8836 100154232 gamma-glutamyl hydrolase gamma-glutamyl hydrolase 23676093 Structural and functional annotation of the porcine immunome
GABPA Dawson et al., 2013 2551 100737779 GA binding protein transcription factor subunit alpha GA binding protein transcription factor subunit alpha 23676093 Structural and functional annotation of the porcine immunome
GNG10 Dawson et al., 2013 2790 100515992 G protein subunit gamma 10 G protein subunit gamma 10 23676093 Structural and functional annotation of the porcine immunome
GNB4 Dawson et al., 2013 59345 100524280 G protein subunit beta 4 G protein subunit beta 4 23676093 Structural and functional annotation of the porcine immunome
GNB1 Dawson et al., 2013 2782 110261346 G protein subunit beta 1 G protein subunit beta 1 23676093 Structural and functional annotation of the porcine immunome
FUNDC1 Dawson et al., 2013 139341 100518350 FUN14 domain containing 1 FUN14 domain containing 1 23676093 Structural and functional annotation of the porcine immunome
FMR1 Dawson et al., 2013 2332 100155078 fragile X messenger ribonucleoprotein 1 Fragile X messenger ribonucleoprotein 1 23676093 Structural and functional annotation of the porcine immunome
FYTTD1 Dawson et al., 2013 84248 100622532 forty-two-three domain containing 1 forty-two-three domain containing 1 23676093 Structural and functional annotation of the porcine immunome
FNDC3A Dawson et al., 2013 22862 100620938 fibronectin type III domain containing 3A fibronectin type III domain containing 3A 23676093 Structural and functional annotation of the porcine immunome
FGFR1OP2 Dawson et al., 2013 26127 100157490 FGFR1 oncogene partner 2 FGFR1 oncogene partner 2 23676093 Structural and functional annotation of the porcine immunome
FBXO6 Dawson et al., 2013 26270 100524148 F-box protein 6 F-box protein 6 23676093 Structural and functional annotation of the porcine immunome
FBXO48 Dawson et al., 2013 554251 106509795 F-box protein 48 F-box protein 48 23676093 Structural and functional annotation of the porcine immunome
FAM76A Dawson et al., 2013 199870 100627656 family with sequence similarity 76 member A family with sequence similarity 76 member A 23676093 Structural and functional annotation of the porcine immunome
FAM32A Dawson et al., 2013 26017 100511743 family with sequence similarity 32 member A family with sequence similarity 32 member A 23676093 Structural and functional annotation of the porcine immunome
FAM111B Dawson et al., 2013 374393 100517326 FAM111 trypsin like peptidase B FAM111 trypsin like peptidase B 23676093 Structural and functional annotation of the porcine immunome
EWSR1 Dawson et al., 2013 2130 100156911 EWS RNA binding protein 1 EWS RNA binding protein 1 23676093 Structural and functional annotation of the porcine immunome
ETV7 Dawson et al., 2013 51513 100156210 ETS variant transcription factor 7 ETS variant transcription factor 7 23676093 Structural and functional annotation of the porcine immunome
ETV6 Dawson et al., 2013 2120 100157726 ETS variant transcription factor 6 ETS variant transcription factor 6 23676093 Structural and functional annotation of the porcine immunome
ETNK1 Dawson et al., 2013 55500 110260724 ethanolamine kinase 1 ethanolamine kinase 1 23676093 Structural and functional annotation of the porcine immunome
EED Dawson et al., 2013 8726 100521029 embryonic ectoderm development embryonic ectoderm development 23676093 Structural and functional annotation of the porcine immunome
EHD4 Dawson et al., 2013 30844 100738234 EH domain containing 4 EH domain containing 4 23676093 Structural and functional annotation of the porcine immunome
ENTPD7 Dawson et al., 2013 57089 100157585 ectonucleoside triphosphate diphosphohydrolase 7 ectonucleoside triphosphate diphosphohydrolase 7 23676093 Structural and functional annotation of the porcine immunome
ENTPD4 Dawson et al., 2013 9583 100155254 ectonucleoside triphosphate diphosphohydrolase 4 ectonucleoside triphosphate diphosphohydrolase 4 23676093 Structural and functional annotation of the porcine immunome
ECD Dawson et al., 2013 11319 100157830 ecdysoneless cell cycle regulator ecdysoneless cell cycle regulator 23676093 Structural and functional annotation of the porcine immunome
DNAJC24 Dawson et al., 2013 120526 100515252 DnaJ heat shock protein family (Hsp40) member C24 DnaJ heat shock protein family (Hsp40) member C24 23676093 Structural and functional annotation of the porcine immunome
DNAJC13 Dawson et al., 2013 23317 100152107 DnaJ heat shock protein family (Hsp40) member C13 DnaJ heat shock protein family (Hsp40) member C13 23676093 Structural and functional annotation of the porcine immunome
DNAJC1 Dawson et al., 2013 64215 100519794 DnaJ heat shock protein family (Hsp40) member C1 DnaJ heat shock protein family (Hsp40) member C1 23676093 Structural and functional annotation of the porcine immunome
DNAJB14 Dawson et al., 2013 79982 100511887 DnaJ heat shock protein family (Hsp40) member B14 DnaJ heat shock protein family (Hsp40) member B14 23676093 Structural and functional annotation of the porcine immunome
DNAJA1 Dawson et al., 2013 3301 100512008 DnaJ heat shock protein family (Hsp40) member A1 DnaJ heat shock protein family (Hsp40) member A1 23676093 Structural and functional annotation of the porcine immunome
DRAM1 Dawson et al., 2013 55332 100462750 DNA damage regulated autophagy modulator 1 DNA damage regulated autophagy modulator 1 23676093 Structural and functional annotation of the porcine immunome
DDX60 Dawson et al., 2013 55601 100158037 DExD/H-box helicase 60 DExD/H-box helicase 60 23676093 Structural and functional annotation of the porcine immunome
DTX3L Dawson et al., 2013 151636 100520459 deltex E3 ubiquitin ligase 3L deltex E3 ubiquitin ligase 3L 23676093 Structural and functional annotation of the porcine immunome
DHRS11 Dawson et al., 2013 79154 100513307 dehydrogenase/reductase 11 dehydrogenase/reductase 11 23676093 Structural and functional annotation of the porcine immunome
DCP1A Dawson et al., 2013 55802 100623102 decapping mRNA 1A decapping mRNA 1A 23676093 Structural and functional annotation of the porcine immunome
DCAF11 Dawson et al., 2013 80344 100157270 DDB1 and CUL4 associated factor 11 DDB1 and CUL4 associated factor 11 23676093 Structural and functional annotation of the porcine immunome
CYB5B Dawson et al., 2013 80777 100286856 cytochrome b5 type B cytochrome b5 type B 23676093 Structural and functional annotation of the porcine immunome
CCNJ Dawson et al., 2013 54619 100154790 cyclin J cyclin J 23676093 Structural and functional annotation of the porcine immunome
CUL5 Dawson et al., 2013 8065 100525708 cullin 5 cullin 5 23676093 Structural and functional annotation of the porcine immunome
CUL2 Dawson et al., 2013 8453 100512186 cullin 2 cullin 2 23676093 Structural and functional annotation of the porcine immunome
CRNKL1 Dawson et al., 2013 51340 100512506 crooked neck pre-mRNA splicing factor 1 crooked neck pre-mRNA splicing factor 1 23676093 Structural and functional annotation of the porcine immunome
CNIH4 Dawson et al., 2013 29097 100523134 cornichon family AMPA receptor auxiliary protein 4 cornichon family AMPA receptor auxiliary protein 4 23676093 Structural and functional annotation of the porcine immunome
CCDC18 Dawson et al., 2013 343099 100518781 coiled-coil domain containing 18 coiled-coil domain containing 18 23676093 Structural and functional annotation of the porcine immunome
CCDC167 Dawson et al., 2013 154467 100152857 coiled-coil domain containing 167 coiled-coil domain containing 167 23676093 Structural and functional annotation of the porcine immunome
CCDC126 Dawson et al., 2013 90693 100621460 coiled-coil domain containing 126 coiled-coil domain containing 126 23676093 Structural and functional annotation of the porcine immunome
CMTM6 Dawson et al., 2013 54918 100511532 CKLF like MARVEL transmembrane domain containing 6 CKLF like MARVEL transmembrane domain containing 6 23676093 Structural and functional annotation of the porcine immunome
C21ORF91 Dawson et al., 2013 54149 100736918 chromosome 21 open reading frame 91 chromosome 13 C21orf91 homolog 23676093 Structural and functional annotation of the porcine immunome
C15ORF48 Dawson et al., 2013 84419 100499505 chromosome 15 open reading frame 48 chromosome 1 C15orf48 homolog 23676093 Structural and functional annotation of the porcine immunome
CHD1 Dawson et al., 2013 1105 100525390 chromodomain helicase DNA binding protein 1 chromodomain helicase DNA binding protein 1 23676093 Structural and functional annotation of the porcine immunome
CEPT1 Dawson et al., 2013 10390 100154792 choline/ethanolamine phosphotransferase 1 choline/ethanolamine phosphotransferase 1 23676093 Structural and functional annotation of the porcine immunome
CHMP7 Dawson et al., 2013 91782 110256869 charged multivesicular body protein 7 charged multivesicular body protein 7 23676093 Structural and functional annotation of the porcine immunome
CHMP5 Dawson et al., 2013 51510 100513035 charged multivesicular body protein 5 charged multivesicular body protein 5 23676093 Structural and functional annotation of the porcine immunome
CENPK Dawson et al., 2013 64105 100512688 centromere protein K centromere protein K 23676093 Structural and functional annotation of the porcine immunome
CDC37L1 Dawson et al., 2013 55664 100522234 cell division cycle 37 like 1, HSP90 cochaperone cell division cycle 37 like 1, HSP90 cochaperone 23676093 Structural and functional annotation of the porcine immunome
CIDEB Dawson et al., 2013 27141 100127160 cell death inducing DFFA like effector b cell death inducing DFFA like effector b 23676093 Structural and functional annotation of the porcine immunome
CD8B Dawson et al., 2013 926 396636 CD8b molecule CD8b molecule 23676093 Structural and functional annotation of the porcine immunome
CD68 Dawson et al., 2013 968 103158530 CD68 molecule CD68 molecule 23676093 Structural and functional annotation of the porcine immunome
CD3E Dawson et al., 2013 916 397455 CD3 epsilon subunit of T-cell receptor complex CD3 epsilon subunit of T-cell receptor complex 23676093 Structural and functional annotation of the porcine immunome
CD3D Dawson et al., 2013 915 396661 CD3 delta subunit of T-cell receptor complex CD3 delta subunit of T-cell receptor complex 23676093 Structural and functional annotation of the porcine immunome
CD2 Dawson et al., 2013 914 396662 CD2 molecule CD2 molecule 23676093 Structural and functional annotation of the porcine immunome
CD163L1 Dawson et al., 2013 283316 100144477 CD163 molecule like 1 CD163 molecule-like 1 23676093 Structural and functional annotation of the porcine immunome
CD163 Dawson et al., 2013 9332 397031 CD163 molecule CD163 molecule 23676093 Structural and functional annotation of the porcine immunome
CNOT7 Dawson et al., 2013 29883 100154442 CCR4-NOT transcription complex subunit 7 CCR4-NOT transcription complex subunit 7 23676093 Structural and functional annotation of the porcine immunome
CCRL2 Dawson et al., 2013 9034 414370 C-C motif chemokine receptor like 2 C-C motif chemokine receptor like 2 23676093 Structural and functional annotation of the porcine immunome
CBLL1 Dawson et al., 2013 79872 100623482 Cbl proto-oncogene like 1 Cbl proto-oncogene like 1 23676093 Structural and functional annotation of the porcine immunome
CASP3 Dawson et al., 2013 836 397244 caspase 3 caspase 3 23676093 Structural and functional annotation of the porcine immunome
CNDP2 Dawson et al., 2013 55748 100158127 carnosine dipeptidase 2 carnosine dipeptidase 2 23676093 Structural and functional annotation of the porcine immunome
CAPZA2 Dawson et al., 2013 830 100037958 capping actin protein of muscle Z-line subunit alpha 2 capping actin protein of muscle Z-line subunit alpha 2 23676093 Structural and functional annotation of the porcine immunome
CNPY2 Dawson et al., 2013 10330 100151912 canopy FGF signaling regulator 2 canopy FGF signaling regulator 2 23676093 Structural and functional annotation of the porcine immunome
CAST Dawson et al., 2013 831 397135 calpastatin calpastatin 23676093 Structural and functional annotation of the porcine immunome
CAB39L Dawson et al., 2013 81617 100519104 calcium binding protein 39 like calcium binding protein 39 like 23676093 Structural and functional annotation of the porcine immunome
BAZ1A Dawson et al., 2013 11177 100151954 bromodomain adjacent to zinc finger domain 1A bromodomain adjacent to zinc finger domain 1A 23676093 Structural and functional annotation of the porcine immunome
BPIFB6 Dawson et al., 2013 128859 100736799 BPI fold containing family B member 6 BPI fold containing family B member 6 23676093 Structural and functional annotation of the porcine immunome
BFAR Dawson et al., 2013 51283 100625875 bifunctional apoptosis regulator bifunctional apoptosis regulator 23676093 Structural and functional annotation of the porcine immunome
B2M Dawson et al., 2013 567 110255236 beta-2-microglobulin beta-2-microglobulin 23676093 Structural and functional annotation of the porcine immunome
BLZF1 Dawson et al., 2013 8548 100622972 basic leucine zipper nuclear factor 1 basic leucine zipper nuclear factor 1 23676093 Structural and functional annotation of the porcine immunome
BATF3 Dawson et al., 2013 55509 100621683 basic leucine zipper ATF-like transcription factor 3 basic leucine zipper ATF-like transcription factor 3 23676093 Structural and functional annotation of the porcine immunome
AIDA Dawson et al., 2013 64853 100518326 axin interactor, dorsalization associated axin interactor, dorsalization associated 23676093 Structural and functional annotation of the porcine immunome
ATP11C Dawson et al., 2013 286410 100523658 ATPase phospholipid transporting 11C ATPase phospholipid transporting 11C 23676093 Structural and functional annotation of the porcine immunome
ATP6V1B2 Dawson et al., 2013 526 106504095 ATPase H+ transporting V1 subunit B2 ATPase H+ transporting V1 subunit B2 23676093 Structural and functional annotation of the porcine immunome
ATP6V0A2 Dawson et al., 2013 23545 100154525 ATPase H+ transporting V0 subunit a2 ATPase H+ transporting V0 subunit a2 23676093 Structural and functional annotation of the porcine immunome
ATAD2B Dawson et al., 2013 54454 100518905 ATPase family AAA domain containing 2B ATPase family AAA domain containing 2B 23676093 Structural and functional annotation of the porcine immunome
ATAD1 Dawson et al., 2013 84896 100157471 ATPase family AAA domain containing 1 ATPase family AAA domain containing 1 23676093 Structural and functional annotation of the porcine immunome
ATL2 Dawson et al., 2013 64225 100521264 atlastin GTPase 2 atlastin GTPase 2 23676093 Structural and functional annotation of the porcine immunome
ATXN7 Dawson et al., 2013 6314 100519688 ataxin 7 ataxin 7 23676093 Structural and functional annotation of the porcine immunome
ASRGL1 Dawson et al., 2013 80150 100517023 asparaginase and isoaspartyl peptidase 1 asparaginase and isoaspartyl peptidase 1 23676093 Structural and functional annotation of the porcine immunome
AIFM1 Dawson et al., 2013 9131 100524062 apoptosis inducing factor mitochondria associated 1 apoptosis inducing factor mitochondria associated 1 23676093 Structural and functional annotation of the porcine immunome
APOOL Dawson et al., 2013 139322 100153260 apolipoprotein O like apolipoprotein O like 23676093 Structural and functional annotation of the porcine immunome
ANKRD49 Dawson et al., 2013 54851 100516989 ankyrin repeat domain 49 ankyrin repeat domain 49 23676093 Structural and functional annotation of the porcine immunome
ANKRD12 Dawson et al., 2013 23253 100519490 ankyrin repeat domain 12 ankyrin repeat domain 12 23676093 Structural and functional annotation of the porcine immunome
ANKMY2 Dawson et al., 2013 57037 100627896 ankyrin repeat and MYND domain containing 2 ankyrin repeat and MYND domain containing 2 23676093 Structural and functional annotation of the porcine immunome
ANKLE2 Dawson et al., 2013 23141 100624394 ankyrin repeat and LEM domain containing 2 ankyrin repeat and LEM domain containing 2 23676093 Structural and functional annotation of the porcine immunome
ANKDD1A Dawson et al., 2013 348094 100515000 ankyrin repeat and death domain containing 1A ankyrin repeat and death domain containing 1A 23676093 Structural and functional annotation of the porcine immunome
AGTRAP Dawson et al., 2013 57085 100524812 angiotensin II receptor associated protein angiotensin II receptor associated protein 23676093 Structural and functional annotation of the porcine immunome
APPBP2 Dawson et al., 2013 10513 100525889 amyloid beta precursor protein binding protein 2 amyloid beta precursor protein binding protein 2 23676093 Structural and functional annotation of the porcine immunome
AMBN Dawson et al., 2013 258 397102 ameloblastin ameloblastin 23676093 Structural and functional annotation of the porcine immunome
ALDH9A1 Dawson et al., 2013 223 100153809 aldehyde dehydrogenase 9 family member A1 aldehyde dehydrogenase 9 family member A1 23676093 Structural and functional annotation of the porcine immunome
ALDH1L2 Dawson et al., 2013 160428 100151976 aldehyde dehydrogenase 1 family member L2 aldehyde dehydrogenase 1 family member L2 23676093 Structural and functional annotation of the porcine immunome
AKAP7 Dawson et al., 2013 9465 100523651 A-kinase anchoring protein 7 A-kinase anchoring protein 7 23676093 Structural and functional annotation of the porcine immunome
ARL6IP1 Dawson et al., 2013 23204 100625874 ADP ribosylation factor like GTPase 6 interacting protein 1 ADP ribosylation factor like GTPase 6 interacting protein 1 23676093 Structural and functional annotation of the porcine immunome
AK3 Dawson et al., 2013 50808 100155691 adenylate kinase 3 adenylate kinase 3 23676093 Structural and functional annotation of the porcine immunome
ACSL5 Dawson et al., 2013 51703 100157521 acyl-CoA synthetase long chain family member 5 acyl-CoA synthetase long chain family member 5 23676093 Structural and functional annotation of the porcine immunome
ACBD3 Dawson et al., 2013 64746 494461 acyl-CoA binding domain containing 3 acyl-CoA binding domain containing 3 23676093 Structural and functional annotation of the porcine immunome
ABHD2 Dawson et al., 2013 11057 100153434 abhydrolase domain containing 2, acylglycerol lipase abhydrolase domain containing 2, acylglycerol lipase 23676093 Structural and functional annotation of the porcine immunome
AGPAT3 Dawson et al., 2013 56894 100233171 1-acylglycerol-3-phosphate O-acyltransferase 3 1-acylglycerol-3-phosphate O-acyltransferase 3 23676093 Structural and functional annotation of the porcine immunome
GIMAP5 Dawson et al., 2013 55340 102163082 GTPase, IMAP family member 5 GTPase, IMAP family member 5 23676093 Structural and functional annotation of the porcine immunome
FCGR3A Dawson et al., 2013 2214 406193 Fc gamma receptor IIIa Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 23676093 Structural and functional annotation of the porcine immunome
VMP1 Dawson et al., 2013 81671 100524644 vacuole membrane protein 1 23676093 Structural and functional annotation of the porcine immunome
RGS16 Auray et al., 2016 6004 397544 regulator of G protein signaling 16 regulator of G protein signaling 16 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
PTGS1 Auray et al., 2016 5742 397541 prostaglandin-endoperoxide synthase 1 prostaglandin-endoperoxide synthase 1 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
IL2RA Auray et al., 2016 3559 396814 interleukin 2 receptor subunit alpha interleukin 2 receptor subunit alpha 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
GZMA Auray et al., 2016 3001 100526762 granzyme A granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
FAS Auray et al., 2016 355 396826 Fas cell surface death receptor Fas cell surface death receptor 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
CSF3 Auray et al., 2016 1440 396839 colony stimulating factor 3 colony stimulating factor 3 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
CD80 Auray et al., 2016 941 397161 CD80 molecule CD80 molecule 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
CD69 Auray et al., 2016 969 397165 CD69 molecule CD69 molecule 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
CCL20 Auray et al., 2016 6364 553951 C-C motif chemokine ligand 20 C-C motif chemokine ligand 20 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
PKIA Auray et al., 2016 5569 397408 cAMP-dependent protein kinase inhibitor alpha cAMP-dependent protein kinase inhibitor alpha 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
ADM Auray et al., 2016 133 397195 adrenomedullin adrenomedullin 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
IL1RN Auray et al., 2016 3557 397499 interleukin 1 receptor antagonist interleukin 1 receptor antagonist 27213692 Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression